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• W2009233000 abstract "The effect of the trace elements fluorine, molybdenum, vanadium, manganese and selenium on fluoride retention and dental caries experience in the white rat was studied in four experimental series. In Series I, F and Mo, separately or in combination were administered in the drinking water during pregnancy and lactation and subsequently to the offspring over a period of 120 days. The dosage levels were 50 p.p.m. F, 25 p.p.m. Mo and 50 p.p.m. Mo. The combined administration of Mo and F was significantly more effective in reducing dental caries than the administration of F alone. When F and Mo at levels of 0.5 mg F and 1.0 mg Mo were administered by stomach tube daily after weaning over a period of 120 days (Series II), the combined administration of F and Mo was not more effective in reducing dental caries than the administration of F alone. In Series III, F, Mo and Mn at concentrations of 50 p.p.m. each, and V at a concentration of 10 p.p.m. were administered to weaned rats in the drinking water for 90 days. The effect of these trace elements was studied for each trace element separately and in combination with F, The elements Mo, Mn and V did not significantly reduce dental caries; simultaneously administered with fluorine, these trace elements did not mediate higher caries reductions than fluorine alone. Selenium was given as sodium selenite at levels of 5 p.p.m. and 10 p.p.m. (whole compound) in the drinking water of the mothers during pregnancy and lactation and subsequently to the offspring over a period of 120 days (Series IV). Sodium selenite increased dental caries significantly. Fluoride retention in the femora was not changed significantly by the ingestion of Mo, Mn, V and Se. Several trace elements other than fluorine have been studied to evaluate their influence on susceptibility to dental caries. Epidemiological studies in the human and laboratory studies in rodents indicate that Mo, V, Mn, Cu and B may reduce dental caries while Se was found to enhance dental decay. The results of several investigations in humans and rodents indicate that Mo when present in food and drinking water may be responsible for caries reduction. It was suggested that the effect of Mo on dental caries is due to a higher F-retention. Other studies suggest that similar interactions may exist between F and Mn, F and V, and F and Al. In the present study the effect of Mo, V, Mn and Se on dental caries and F-retention in the rat has been studied. It was found: (1) The combined administration of Mo and F in the drinking water was significantly more effective in reducing dental caries than the administration of F alone; (2) Se significantly increased dental caries in the rat if administered in the drinking water during the entire period of tooth formation; (3) F-retention was not changed significantly by the administration of the trace elements studied." @default.
• W2009233000 created "2016-06-24" @default.
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• W2009233000 date "1961-01-01" @default.
• W2009233000 modified "2023-10-14" @default.
• W2009233000 title "Effects of some trace elements on fluoride retention and dental caries" @default.
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• W2009233000 doi "https://doi.org/10.1016/0003-9969(61)90018-8" @default.
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