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• W2009235791 endingPage "e29269" @default.
• W2009235791 startingPage "e29269" @default.
• W2009235791 abstract "The P-type ATPase family constitutes a collection of ion pumps that form phosphorylated intermediates during ion transport. One of the best known members of this family is the Na⁺,K⁺-ATPase. The catalytic subunit of the Na⁺,K⁺-ATPase includes several functional domains that determine its enzymatic and trafficking properties.Using the yeast two-hybrid system we found that protein phosphatase 2A (PP2A) catalytic C-subunit is a specific Na⁺,K⁺-ATPase interacting protein. PP-2A C-subunit interacted with the Na⁺,K⁺-ATPase, but not with the homologous sequences of the H⁺,K⁺-ATPase. We confirmed that the Na⁺,K⁺-ATPase interacts with a complex of A- and C-subunits in native rat kidney. Arrestins and G-protein coupled receptor kinases (GRKs) are important regulators of G-protein coupled receptor (GPCR) signaling, and they also regulate Na⁺,K⁺-ATPase trafficking through direct association. PP2A inhibits association between the Na⁺,K⁺-ATPase and arrestin, and diminishes the effect of arrestin on Na⁺,K⁺-ATPase trafficking. GRK phosphorylates the Na⁺,K⁺-ATPase and PP2A can at least partially reverse this phosphorylation.Taken together, these data demonstrate that the sodium pump belongs to a growing list of ion transport proteins that are regulated through direct interactions with the catalytic subunit of a protein phosphatase." @default.
• W2009235791 created "2016-06-24" @default.
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• W2009235791 creator A5086678014 @default.
• W2009235791 date "2011-12-29" @default.
• W2009235791 modified "2023-09-26" @default.
• W2009235791 title "Protein Phosphatase 2A Interacts with the Na+,K+-ATPase and Modulates Its Trafficking by Inhibition of Its Association with Arrestin" @default.
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• W2009235791 doi "https://doi.org/10.1371/journal.pone.0029269" @default.
• W2009235791 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3248462" @default.
• W2009235791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22242112" @default.
• W2009235791 hasPublicationYear "2011" @default.
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