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- W2009235874 abstract "The aetiologic agent of avian colibacillosis isEscherichia coli. Colibacillosis is a disease that causes mortality and production performance problems in chickens which results in economic losses for the poultry industry. It will be increasingly important for scientists to identify novel solutions that can be implemented which will provide poultry producers with a tool to manage this economically important disease. The purpose of this investigation was to determine whether lipopolysaccharide (LPS) could be used as a positive control to evaluate novel chemistries for immunopotentiator activity in battery or floor-pen avian colibacillosis models in chickens. In the battery study, subcutaneous administration ofLPSto one-day-old broiler cockerels caused a significant reduction (P < 0.003) in all parameters of colibacillosis evaluated, i.e. mean air sac lesion scores, per cent air sac lesions,E colire-isolation and per cent mortality. However, in the floor-pen study, subcutaneous administration to one-day-old broiler chicks resulted in a numerical, but not stastically significant reduction (P < 0.1) in mortality associated with colibacillosis. These data indicate thatLPScan be used as a positive control to evaluate the efficacy of immunopotentiator drug candidates in avian colibacillosis models." @default.
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- W2009235874 date "1999-01-01" @default.
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- W2009235874 title "Use of lipopolysaccharide (LPS) as a positive control for the evaluation of immunopotentiating drug candidates in experimental avian colibacillosis models" @default.
- W2009235874 doi "https://doi.org/10.1053/rvsc.1998.0237" @default.
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