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- W2009248529 abstract "The mechanism of the inhibitory effect of local anesthetics on hormone secretion was studied in the GH4C1 line of rat pituitary tumor-derived cells. Lidocaine between 0.1 and 5 mM exerted significant dose-dependent inhibition on the increment in cytosol Ca2+ concentration ([Ca2+]i) and prolactin (PRL) secretion induced by 30 mM K+. For both effects the IC50 was 0.25 mM and maximal inhibition occurred at 5 mM. A normal response returned within 20 min after removal of lidocaine from the incubation medium. 1 μM tetrodotoxin had no effect on the 30 mM K+ induced [Ca2+]i transient or PRL secretion, indicating that Na+ channels are not involved in the inhibitory effect of lidocaine. Lidocaine similarly inhibited the [Ca2+]i increment and PRL secretion induced by 30% medium hyposmolarity and 1 μM Bay K 8644. Lidocaine was much less effective in inhibiting secretion induced by 1 μM phorbol 12-myristate 13-acetate (TPA) or 5 μM forskolin. 5 mM procaine produced effects similar to those of lidocaine. Our data suggest that in GH4C1 cells local anesthetics depress secretagogue-induced PRL secretion primarily by blocking Ca+ influx, probably through L-type Ca2+ channels." @default.
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- W2009248529 title "Lidocaine inhibits prolactin secretion in GH4C1 cells by blocking calcium influx" @default.
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- W2009248529 doi "https://doi.org/10.1016/0303-7207(92)90244-z" @default.
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