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• W2009253437 abstract "The UV response of four K12 strains of E. coli that differ in their repair characteristics was studied as a function of their stage of growth. The four strains used were AB1157 that possesses the full complement of repair genes, the excision-deficient AB-1886 (uvrA-6), the recombination-deficient AB2463 (recA-13) and the excision- and recombination-deficient AB2480 (recA-13, uvrA-6). The UV sensitivity-growth phase profile of the double mutant showed a decrease in early exponential phase and then an increase to the original level by the start of stationary phase that remained unchanged up to 48 h. This decreased sensitivity was found to be associated with an increase in the shoulder of the full UV survivor curve. Deviations from the AB2480 profile shown by other strains reflect the influence of repair mechanisms on the UV-induced damage in cells, and indicate the influence that physiological changes occurring during different phases of the growth cycle have on the efficiencies of the repair systems. Since AB1886 showed a similar profile to AB2480, it appears that postreplicatory recombination repair is unaffected by the intracellular changes. However, the recombination-negative AB2463 showed a marked increase in UV sensitivity throughout exponential growth followed by an increase in resistance that continued up to 48 h. It is postulated that this increased sensitivity in rapidly dividing cells results from a decreased repair efficiency due to a decrease in time before DNA replication takes place and also to a temporary decrease in numbers of repair enzyme molecules within the cells. The enzyme concentration increases in stationary phase and accounts for the enhanced recovery noted during this stage of growth. Results of experiments on pre-irradiation and postirradiation liquid holding of cells support this view. Studies with AB1157 indicate the interrelationship of excision and recombination, working sequentially, at different stages of the growth cycle. A comparison of the AB1157 results with those from single mutants indicate that while both processes are necessary for maximum cellular recovery, in most cases recombination can compensate for decreased excision repair efficiency. However, when excision efficiency falls below a certain limit, recombination can no longer fully cope with the partially repaired cells and an increased sensitivity results. Possible reasons for the interaction of these two dark repair processes are discussed." @default.
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• W2009253437 modified "2023-10-13" @default.
• W2009253437 title "The variation in UV sensitivity of four K12 strains of Escherichia coli as a function of their stage of growth" @default.
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• W2009253437 doi "https://doi.org/10.1016/0027-5107(72)90058-9" @default.
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