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- W2009255603 abstract "Aerosolized prostacyclin (PGI 2 ) produces selective pulmonary vasodilation in patients with pulmonary hypertension (PH). The response to PGI 2 may be increased by phosphodiesterase type 3 inhibitors such as milrinone. We studied the dose response effects of aerosolized PGI 2 and aerosolized milrinone both alone and in combination on pulmonary and systemic hemodynamics in newborn lambs with N ω -nitro-l-arginine methyl ester (l-NAME)-induced PH. We hypothesized that coaerosolization of PGI 2 with milrinone would additively decrease pulmonary vascular resistance (PVR), prolong the duration of action of PGI 2 , and selectively dilate the pulmonary vasculature. Near-term lambs were delivered by C-section and instrumented and PH was induced by l-NAME (bolus 25 mg/kg; infusion 10 mg·kg −1 ·h −1 ) and indomethacin. In the first set of experiments, PGI 2 was aerosolized at random doses of 2, 20, 100, 200, 500, and 1,000 ng·kg −1 ·min −1 followed by milrinone at doses of 0.1, 1, and 10 μg·kg −1 ·min −1 over 10 min. In the second set of experiments, milrinone at 1 μg·kg −1 ·min −1 was aerosolized in combination with PGI 2 at doses of 20, 100, and 200 ng·kg −1 ·min −1 over 10 min. Pulmonary arterial pressures (PAP) and PVR decreased significantly with increasing doses of aerosolized PGI 2 and milrinone. The combination of PGI 2 and milrinone significantly reduced PAP and PVR more than either of the drugs aerosolized alone. Addition of milrinone significantly increased the duration of action of PGI 2 . When aerosolized independently, PGI 2 and milrinone selectively dilated the pulmonary vasculature but the combination did not. Milrinone enhances the vasodilatory effects of PGI 2 on the pulmonary vasculature but caution must be exercised regarding systemic hypotension." @default.
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- W2009255603 date "2010-09-01" @default.
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- W2009255603 title "Prostacyclin and milrinone by aerosolization improve pulmonary hemodynamics in newborn lambs with experimental pulmonary hypertension" @default.
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- W2009255603 doi "https://doi.org/10.1152/japplphysiol.01082.2009" @default.
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