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• W2009262485 abstract "The role of swelling-activated currents in cell volume regulation is unclear. Currents elicited by swelling rabbit ventricular myocytes in solutions with 0.6-0.9x normal osmolarity were studied using amphotericin perforated patch clamp techniques, and cell volume was examined concurrently by digital video microscopy. Graded swelling caused graded activation of an inwardly rectifying, time-independent cation current (ICir,swell) that was reversibly blocked by Gd3+, but ICir,swell was not detected in isotonic or hypertonic media. This current was not related to IK1 because it was insensitive to Ba2+. The PK/PNa ratio for ICir,swell was 5.9 +/- 0.3, implying that inward current is largely Na+ under physiological conditions. Increasing bath K+ increased gCir,swell but decreased rectification. Gd3+ block was fitted with a K0.5 of 1.7 +/- 0.3 microM and Hill coefficient, n, of 1.7 +/- 0.4. Exposure to Gd3+ also reduced hypotonic swelling by up to approximately 30%, and block of current preceded the volume change by approximately 1 min. Gd3+-induced cell shrinkage was proportional to ICir,swell when ICir,swell was varied by graded swelling or Gd3+ concentration and was voltage dependent, reflecting the voltage dependence of ICir,swell. Integrating the blocked ion flux and calculating the resulting change in osmolarity suggested that ICir,swell was sufficient to explain the majority of the volume change at -80 mV. In addition, swelling activated an outwardly rectifying Cl- current, ICl,swell. This current was absent after Cl- replacement, reversed at ECl, and was blocked by 1 mM 9-anthracene carboxylic acid. Block of ICl,swell provoked a 28% increase in swelling in hypotonic media. Thus, both cation and anion swelling-activated currents modulated the volume of ventricular myocytes. Besides its effects on cell volume, ICir,swell is expected to cause diastolic depolarization. Activation of ICir, swell also is likely to affect contraction and other physiological processes in myocytes." @default.
• W2009262485 created "2016-06-24" @default.
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• W2009262485 date "1997-09-01" @default.
• W2009262485 modified "2023-09-23" @default.
• W2009262485 title "Swelling-activated Gd3+-sensitive Cation Current and Cell Volume Regulation in Rabbit Ventricular Myocytes" @default.
• W2009262485 cites W1531796828 @default.
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• W2009262485 cites W188963926 @default.
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• W2009262485 cites W1973105862 @default.
• W2009262485 cites W1979856671 @default.
• W2009262485 cites W1980964288 @default.
• W2009262485 cites W1981562838 @default.
• W2009262485 cites W1983867164 @default.
• W2009262485 cites W1984746596 @default.
• W2009262485 cites W1991407028 @default.
• W2009262485 cites W1992532194 @default.
• W2009262485 cites W1994147156 @default.
• W2009262485 cites W2000460923 @default.
• W2009262485 cites W2003804186 @default.
• W2009262485 cites W2013497159 @default.
• W2009262485 cites W2015126555 @default.
• W2009262485 cites W2020452164 @default.
• W2009262485 cites W2023869925 @default.
• W2009262485 cites W2026289366 @default.
• W2009262485 cites W2028377543 @default.
• W2009262485 cites W2036145275 @default.
• W2009262485 cites W2039120663 @default.
• W2009262485 cites W2045152040 @default.
• W2009262485 cites W2045986542 @default.
• W2009262485 cites W2057191789 @default.
• W2009262485 cites W2058081735 @default.
• W2009262485 cites W2061006638 @default.
• W2009262485 cites W2062722270 @default.
• W2009262485 cites W2069795401 @default.
• W2009262485 cites W2070610900 @default.
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• W2009262485 cites W2086275741 @default.
• W2009262485 cites W2088015718 @default.
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• W2009262485 cites W2119443224 @default.
• W2009262485 cites W2121020061 @default.
• W2009262485 cites W2121349030 @default.
• W2009262485 cites W2124969505 @default.
• W2009262485 cites W2125885577 @default.
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• W2009262485 cites W2175512520 @default.
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• W2009262485 doi "https://doi.org/10.1085/jgp.110.3.297" @default.
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