FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009263722> ?p ?o ?g. }

• W2009263722 endingPage "794" @default.
• W2009263722 startingPage "786" @default.
• W2009263722 abstract "Abstract TNF-α-converting enzyme (TACE, herein denoted as Adam17) proteolytically sheds several cell-surface inflammatory proteins, but the physiologic importance of the cleavage of these substrates from leukocyte subsets during inflammation is incompletely understood. In this study, we show that Adam17-null neutrophils have a 2-fold advantage in their initial recruitment during thioglycollate-induced peritonitis, and they roll slower and adhere more readily in the cremaster model than wild-type neutrophils. Although CD44 and ICAM-1 are both in vitro substrates of Adam17, their surface levels are not altered on Adam17-null neutrophils. In contrast, L-selectin levels are elevated up to 10-fold in Adam17-null circulating neutrophils, and their accelerated peritoneal influx, slower rolling, and increased adhesion in the cremaster muscle are dependent on L-selectin. Analysis of mixed chimeras shows that enhanced L-selectin levels and accelerated influx were both cell-intrinsic properties of neutrophils lacking Adam17. In contrast, Adam17-null monocytes display no acceleration of infiltration into the peritoneum in spite of elevated L-selectin surface levels, and their peritoneal influx was independent of L-selectin. Therefore, our data demonstrate substrate and myeloid cell-type specificity of Adam17-mediated cleavage of its substrates, and show that neutrophils and monocytes use distinct mechanisms for infiltration of tissues." @default.
• W2009263722 created "2016-06-24" @default.
• W2009263722 creator A5005773579 @default.
• W2009263722 creator A5019726220 @default.
• W2009263722 creator A5020082525 @default.
• W2009263722 creator A5032614974 @default.
• W2009263722 creator A5035813072 @default.
• W2009263722 creator A5053470073 @default.
• W2009263722 creator A5060790381 @default.
• W2009263722 creator A5065655334 @default.
• W2009263722 creator A5066506904 @default.
• W2009263722 creator A5090275884 @default.
• W2009263722 date "2011-07-21" @default.
• W2009263722 modified "2023-10-01" @default.
• W2009263722 title "Adam17-dependent shedding limits early neutrophil influx but does not alter early monocyte recruitment to inflammatory sites" @default.
• W2009263722 cites W1489600631 @default.
• W2009263722 cites W1622739787 @default.
• W2009263722 cites W1782613870 @default.
• W2009263722 cites W1873121388 @default.
• W2009263722 cites W1895115148 @default.
• W2009263722 cites W1968372771 @default.
• W2009263722 cites W1971444570 @default.
• W2009263722 cites W1978422523 @default.
• W2009263722 cites W1997541998 @default.
• W2009263722 cites W1998469959 @default.
• W2009263722 cites W2004055642 @default.
• W2009263722 cites W2012816457 @default.
• W2009263722 cites W2032494769 @default.
• W2009263722 cites W2035809865 @default.
• W2009263722 cites W2036842448 @default.
• W2009263722 cites W2060859895 @default.
• W2009263722 cites W2065646518 @default.
• W2009263722 cites W2074881372 @default.
• W2009263722 cites W2076173075 @default.
• W2009263722 cites W2079096224 @default.
• W2009263722 cites W2084391700 @default.
• W2009263722 cites W2094238516 @default.
• W2009263722 cites W2094328483 @default.
• W2009263722 cites W2099675490 @default.
• W2009263722 cites W2102637482 @default.
• W2009263722 cites W2105227585 @default.
• W2009263722 cites W2106208034 @default.
• W2009263722 cites W2107100863 @default.
• W2009263722 cites W2110717286 @default.
• W2009263722 cites W2117127822 @default.
• W2009263722 cites W2119445810 @default.
• W2009263722 cites W2128141580 @default.
• W2009263722 cites W2146194904 @default.
• W2009263722 cites W2152364005 @default.
• W2009263722 cites W2157379527 @default.
• W2009263722 cites W2166324296 @default.
• W2009263722 cites W2170999996 @default.
• W2009263722 doi "https://doi.org/10.1182/blood-2010-11-321406" @default.
• W2009263722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3142912" @default.
• W2009263722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21628404" @default.
• W2009263722 hasPublicationYear "2011" @default.
• W2009263722 type Work @default.
• W2009263722 sameAs 2009263722 @default.
• W2009263722 citedByCount "45" @default.
• W2009263722 countsByYear W20092637222012 @default.
• W2009263722 countsByYear W20092637222013 @default.
• W2009263722 countsByYear W20092637222014 @default.
• W2009263722 countsByYear W20092637222015 @default.
• W2009263722 countsByYear W20092637222016 @default.
• W2009263722 countsByYear W20092637222017 @default.
• W2009263722 countsByYear W20092637222018 @default.
• W2009263722 countsByYear W20092637222019 @default.
• W2009263722 countsByYear W20092637222021 @default.
• W2009263722 countsByYear W20092637222022 @default.
• W2009263722 countsByYear W20092637222023 @default.
• W2009263722 crossrefType "journal-article" @default.
• W2009263722 hasAuthorship W2009263722A5005773579 @default.
• W2009263722 hasAuthorship W2009263722A5019726220 @default.
• W2009263722 hasAuthorship W2009263722A5020082525 @default.
• W2009263722 hasAuthorship W2009263722A5032614974 @default.
• W2009263722 hasAuthorship W2009263722A5035813072 @default.
• W2009263722 hasAuthorship W2009263722A5053470073 @default.
• W2009263722 hasAuthorship W2009263722A5060790381 @default.
• W2009263722 hasAuthorship W2009263722A5065655334 @default.
• W2009263722 hasAuthorship W2009263722A5066506904 @default.
• W2009263722 hasAuthorship W2009263722A5090275884 @default.
• W2009263722 hasBestOaLocation W20092637221 @default.
• W2009263722 hasConcept C105702510 @default.
• W2009263722 hasConcept C121332964 @default.
• W2009263722 hasConcept C121853132 @default.
• W2009263722 hasConcept C1491633281 @default.
• W2009263722 hasConcept C150903083 @default.
• W2009263722 hasConcept C153400128 @default.
• W2009263722 hasConcept C203014093 @default.
• W2009263722 hasConcept C207001950 @default.
• W2009263722 hasConcept C2776001837 @default.
• W2009263722 hasConcept C2776354463 @default.
• W2009263722 hasConcept C2776914184 @default.
• W2009263722 hasConcept C2781184567 @default.
• W2009263722 hasConcept C54355233 @default.
• W2009263722 hasConcept C55493867 @default.
• W2009263722 hasConcept C81885089 @default.
• W2009263722 hasConcept C85789140 @default.

• next