FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009263753> ?p ?o ?g. }

• W2009263753 endingPage "1149" @default.
• W2009263753 startingPage "1142" @default.
• W2009263753 abstract "Cholangiocarcinoma (CCA) affects the intra- and extrahepatic bile ducts and is commonly burdened by a late presentation and resulting high mortality rate. Accordingly, finding non-invasive biomarkers with adequate diagnostic/prognostic values is a priority in high-risk populations. In this study, we analyzed proteomes of serum samples from six CCA cases and ten healthy subjects using two-dimensional polyacrylamide gel electrophoresis to identify CCA-associated spots. Thirty-six CCA-associated proteins found in sera were identified by mass spectrometry. α1 β-Glycoprotein (A1BG) and afamin (AFM) were detected consistently at different degrees in CCA sera compared with controls and were validated for their diagnostic and prognostic potential in a larger cohort of 64 patients with CCA, 4 with benign biliary diseases and 20 healthy subjects and compared between pre- and postsurgery serum samples from 26 CCA patients to ascertain a prognostic correlation. A single blot test developed to assess the serum A1BG/AFM ratio could detect CCA cases with 87.5% specificity, 84.4% sensitivity and the levels were significantly higher in CCA compared with controls. A high level of postoperative serum A1BG/AFM ratio was associated with worse outcomes and the infiltration of resection margins. The A1BG/AFM ratio may constitute a novel non-invasive candidate marker to diagnose CCA and its outcomes with high specificity and sensitivity. Prospective studies are awaited to demonstrate the clinical value of this observation." @default.
• W2009263753 created "2016-06-24" @default.
• W2009263753 creator A5003446927 @default.
• W2009263753 creator A5011139799 @default.
• W2009263753 creator A5027438594 @default.
• W2009263753 creator A5030758045 @default.
• W2009263753 creator A5043796810 @default.
• W2009263753 creator A5073101968 @default.
• W2009263753 creator A5078887185 @default.
• W2009263753 date "2012-10-01" @default.
• W2009263753 modified "2023-10-04" @default.
• W2009263753 title "Serum <i>α</i>₁<i>β</i>-glycoprotein and afamin ratio as potential diagnostic and prognostic markers in cholangiocarcinoma" @default.
• W2009263753 cites W1497693870 @default.
• W2009263753 cites W1601826601 @default.
• W2009263753 cites W1775749144 @default.
• W2009263753 cites W1970368087 @default.
• W2009263753 cites W1987883830 @default.
• W2009263753 cites W2035777674 @default.
• W2009263753 cites W2046395773 @default.
• W2009263753 cites W2061496053 @default.
• W2009263753 cites W2069447948 @default.
• W2009263753 cites W2074735908 @default.
• W2009263753 cites W2078797029 @default.
• W2009263753 cites W2081239048 @default.
• W2009263753 cites W2082719569 @default.
• W2009263753 cites W2086487735 @default.
• W2009263753 cites W2091518586 @default.
• W2009263753 cites W2100837269 @default.
• W2009263753 cites W2105612608 @default.
• W2009263753 cites W2111542018 @default.
• W2009263753 cites W2128703407 @default.
• W2009263753 cites W2136272028 @default.
• W2009263753 cites W2158269411 @default.
• W2009263753 cites W2735553444 @default.
• W2009263753 cites W4239180165 @default.
• W2009263753 doi "https://doi.org/10.1258/ebm.2012.012215" @default.
• W2009263753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23104505" @default.
• W2009263753 hasPublicationYear "2012" @default.
• W2009263753 type Work @default.
• W2009263753 sameAs 2009263753 @default.
• W2009263753 citedByCount "21" @default.
• W2009263753 countsByYear W20092637532013 @default.
• W2009263753 countsByYear W20092637532014 @default.
• W2009263753 countsByYear W20092637532015 @default.
• W2009263753 countsByYear W20092637532017 @default.
• W2009263753 countsByYear W20092637532018 @default.
• W2009263753 countsByYear W20092637532019 @default.
• W2009263753 countsByYear W20092637532020 @default.
• W2009263753 countsByYear W20092637532021 @default.
• W2009263753 countsByYear W20092637532022 @default.
• W2009263753 countsByYear W20092637532023 @default.
• W2009263753 crossrefType "journal-article" @default.
• W2009263753 hasAuthorship W2009263753A5003446927 @default.
• W2009263753 hasAuthorship W2009263753A5011139799 @default.
• W2009263753 hasAuthorship W2009263753A5027438594 @default.
• W2009263753 hasAuthorship W2009263753A5030758045 @default.
• W2009263753 hasAuthorship W2009263753A5043796810 @default.
• W2009263753 hasAuthorship W2009263753A5073101968 @default.
• W2009263753 hasAuthorship W2009263753A5078887185 @default.
• W2009263753 hasConcept C104317684 @default.
• W2009263753 hasConcept C108625454 @default.
• W2009263753 hasConcept C126322002 @default.
• W2009263753 hasConcept C142724271 @default.
• W2009263753 hasConcept C153911025 @default.
• W2009263753 hasConcept C188816634 @default.
• W2009263753 hasConcept C2776415932 @default.
• W2009263753 hasConcept C44249647 @default.
• W2009263753 hasConcept C55493867 @default.
• W2009263753 hasConcept C71924100 @default.
• W2009263753 hasConcept C72563966 @default.
• W2009263753 hasConcept C86803240 @default.
• W2009263753 hasConcept C90924648 @default.
• W2009263753 hasConceptScore W2009263753C104317684 @default.
• W2009263753 hasConceptScore W2009263753C108625454 @default.
• W2009263753 hasConceptScore W2009263753C126322002 @default.
• W2009263753 hasConceptScore W2009263753C142724271 @default.
• W2009263753 hasConceptScore W2009263753C153911025 @default.
• W2009263753 hasConceptScore W2009263753C188816634 @default.
• W2009263753 hasConceptScore W2009263753C2776415932 @default.
• W2009263753 hasConceptScore W2009263753C44249647 @default.
• W2009263753 hasConceptScore W2009263753C55493867 @default.
• W2009263753 hasConceptScore W2009263753C71924100 @default.
• W2009263753 hasConceptScore W2009263753C72563966 @default.
• W2009263753 hasConceptScore W2009263753C86803240 @default.
• W2009263753 hasConceptScore W2009263753C90924648 @default.
• W2009263753 hasIssue "10" @default.
• W2009263753 hasLocation W20092637531 @default.
• W2009263753 hasLocation W20092637532 @default.
• W2009263753 hasOpenAccess W2009263753 @default.
• W2009263753 hasPrimaryLocation W20092637531 @default.
• W2009263753 hasRelatedWork W2076993109 @default.
• W2009263753 hasRelatedWork W2295722933 @default.
• W2009263753 hasRelatedWork W2315085516 @default.
• W2009263753 hasRelatedWork W2316407790 @default.
• W2009263753 hasRelatedWork W2378328631 @default.
• W2009263753 hasRelatedWork W2411569915 @default.
• W2009263753 hasRelatedWork W2515762743 @default.
• W2009263753 hasRelatedWork W2531350361 @default.

• next