FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009264256> ?p ?o ?g. }

• W2009264256 endingPage "301" @default.
• W2009264256 startingPage "301" @default.
• W2009264256 abstract "Effect of angiotensin receptor blockade on endothelial function: focus on olmesartan medoxomil Carlos FerrarioHypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, NC, USAAbstract: Endothelial dysfunction is the common link between cardiovascular disease risk factors and the earliest event in the cascade of incidents that results in target organ damage. Angiotensin II, the terminal pressor effector arm of the renin-angiotensin-aldosterone system, increases blood pressure (BP) by vasoconstriction and sodium and fluid retention, and has a pro-oxidative action that induces endothelial dysfunction and contributes to vascular remodeling. Angiotensin receptor blockers (ARBs) reduce BP and morbidity and mortality in patients with hypertension, ventricular hypertrophy, diabetes mellitus, and renal disease. Olmesartan medoxomil is a long-acting, well-tolerated, effective ARB that prevents or reverses endothelial dysfunction in animal models of atherosclerosis, hypertension, diabetes, nephropathy, and retinopathy. Olmesartan medoxomil, a prodrug of olmesartan approved for the treatment of hypertension, has been shown to ameliorate endothelial dysfunction in patients with hypertension or diabetes. In randomized studies, the drug reduces vascular inflammation and the volume of large atherosclerotic plaques, increases the number of regenerative endothelial progenitor cells in the peripheral circulation, improves endothelium-dependent relaxation, and restores the normal resistance vessel morphology. Importantly, the impact of olmesartan medoxomil on endothelial dysfunction is thought to be independent of BP lowering.Keywords: endothelial dysfunction, angiotensin receptor blocker, olmesartan medoxomil, hypertension, atherosclerosis&nbsp" @default.
• W2009264256 created "2016-06-24" @default.
• W2009264256 creator A5088391372 @default.
• W2009264256 date "2009-03-01" @default.
• W2009264256 modified "2023-09-27" @default.
• W2009264256 title "Effect of angiotensin receptor blockade on endothelial function: focus on olmesartan medoxomil" @default.
• W2009264256 cites W1566256360 @default.
• W2009264256 cites W1968366673 @default.
• W2009264256 cites W1970678793 @default.
• W2009264256 cites W1974365418 @default.
• W2009264256 cites W1976734710 @default.
• W2009264256 cites W1976775719 @default.
• W2009264256 cites W1977505869 @default.
• W2009264256 cites W1985317854 @default.
• W2009264256 cites W1988531324 @default.
• W2009264256 cites W1989603944 @default.
• W2009264256 cites W1992173844 @default.
• W2009264256 cites W1999582512 @default.
• W2009264256 cites W2002143964 @default.
• W2009264256 cites W2004840558 @default.
• W2009264256 cites W2008076845 @default.
• W2009264256 cites W2013913603 @default.
• W2009264256 cites W2015791828 @default.
• W2009264256 cites W2016687960 @default.
• W2009264256 cites W2019338486 @default.
• W2009264256 cites W2021011733 @default.
• W2009264256 cites W2021167391 @default.
• W2009264256 cites W2025304094 @default.
• W2009264256 cites W2025672718 @default.
• W2009264256 cites W2026944100 @default.
• W2009264256 cites W2027381170 @default.
• W2009264256 cites W2027494269 @default.
• W2009264256 cites W2031204813 @default.
• W2009264256 cites W2031866170 @default.
• W2009264256 cites W2037589733 @default.
• W2009264256 cites W2039406779 @default.
• W2009264256 cites W2039702404 @default.
• W2009264256 cites W2043360171 @default.
• W2009264256 cites W2044256491 @default.
• W2009264256 cites W2044411320 @default.
• W2009264256 cites W2044773944 @default.
• W2009264256 cites W2044961448 @default.
• W2009264256 cites W2045516356 @default.
• W2009264256 cites W2054200972 @default.
• W2009264256 cites W2055416829 @default.
• W2009264256 cites W2056893352 @default.
• W2009264256 cites W2056976690 @default.
• W2009264256 cites W2058535498 @default.
• W2009264256 cites W2060171803 @default.
• W2009264256 cites W2060629558 @default.
• W2009264256 cites W2066971442 @default.
• W2009264256 cites W2072751592 @default.
• W2009264256 cites W2075120792 @default.
• W2009264256 cites W2075678264 @default.
• W2009264256 cites W2077075851 @default.
• W2009264256 cites W2082329829 @default.
• W2009264256 cites W2083529118 @default.
• W2009264256 cites W2084998863 @default.
• W2009264256 cites W2087325601 @default.
• W2009264256 cites W2087790961 @default.
• W2009264256 cites W2088673900 @default.
• W2009264256 cites W2090114724 @default.
• W2009264256 cites W2093449144 @default.
• W2009264256 cites W2096144092 @default.
• W2009264256 cites W2096372312 @default.
• W2009264256 cites W2099901191 @default.
• W2009264256 cites W2106163583 @default.
• W2009264256 cites W2108246384 @default.
• W2009264256 cites W2110228778 @default.
• W2009264256 cites W2114143920 @default.
• W2009264256 cites W2117200096 @default.
• W2009264256 cites W2117260106 @default.
• W2009264256 cites W2117648804 @default.
• W2009264256 cites W2118061538 @default.
• W2009264256 cites W2119642994 @default.
• W2009264256 cites W2120434113 @default.
• W2009264256 cites W2121156134 @default.
• W2009264256 cites W2124534505 @default.
• W2009264256 cites W2126820133 @default.
• W2009264256 cites W2128236156 @default.
• W2009264256 cites W2128921112 @default.
• W2009264256 cites W2130761693 @default.
• W2009264256 cites W2135038122 @default.
• W2009264256 cites W2137248091 @default.
• W2009264256 cites W2138944238 @default.
• W2009264256 cites W2140912550 @default.
• W2009264256 cites W2141108790 @default.
• W2009264256 cites W2141515134 @default.
• W2009264256 cites W2141784797 @default.
• W2009264256 cites W2142532695 @default.
• W2009264256 cites W2144528818 @default.
• W2009264256 cites W2146081639 @default.
• W2009264256 cites W2146655070 @default.
• W2009264256 cites W2151190145 @default.
• W2009264256 cites W2151788147 @default.
• W2009264256 cites W2152043519 @default.
• W2009264256 cites W2152798629 @default.
• W2009264256 cites W2154816471 @default.

• next