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- W2009270944 abstract "A cDNA from salmon brain which induces a consistent activation of Ca2+ dependent Cl- (Ca(2+)-Cl-) current in Xenopus oocytes in the saline solution was isolated by an expression cloning method. The primary structure showed a high homology with the metabotropic glutamate receptors (mGluR), and a limited homology with the Ca2+/polyvalent cation receptors (CaR). The encoded protein was functionally characterized for the sensitivity to extracellular Ca2+ (Cao2+), and the consistent activation of Ca(2+)-Cl- current was determined to be due to Ca2+ contained in the saline solution. It was also confirmed that the encoded protein has a function to sense glutamate. An increase in inositol 1,4,5-triphosphate turnover was observed when either Ca2+ or glutamate was applied. Thus, the encoded protein was identified as a bifunctional metabotropic receptor for both Ca2+ and glutamate. In addition, rat mGluR1 alpha was also shown to be activated by Cao2+. This is the first report of a G-protein coupled receptor which is activated by two totally different physiological agonists." @default.
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- W2009270944 date "1996-08-19" @default.
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- W2009270944 title "Cloning and characterization of a bifunctional metabotropic receptor activated by both extracellular calcium and glutamate" @default.
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- W2009270944 doi "https://doi.org/10.1016/0014-5793(96)00786-7" @default.
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