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• W2009271487 abstract "The viability of non-homologous end-joining (NHEJ)-defective mice suggests that homologous recombination (HR) might take over its role in DNA repair. To test this hypothesis, we examined gene targeting frequencies (TF) in DNA-PK(cs), Ku80 and poly(ADP-ribose) polymerase (PARP-1) nullizygous cells. We observed a 3-fold TF increase in PARP-1 knockout embryonic stem (ES) cells, which is consistent with the predicted role of PARP-1 as a switch between HR and NHEJ. To a lesser extent, such effect could be reproduced upon chemical inhibition of PARP-1. However, TF was not enhanced in Ku80- or DNA-PK(cs)-defective cells. Our study also suggests an unexpected involvement of DNA-PK(cs) in HR." @default.
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• W2009271487 date "2006-04-01" @default.
• W2009271487 modified "2023-09-23" @default.
• W2009271487 title "Down-regulation of PARP-1, but not of Ku80 or DNA-PKcs, results in higher gene targeting efficiency" @default.
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• W2009271487 doi "https://doi.org/10.1016/j.cellbi.2005.12.005" @default.
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