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- W2009273046 endingPage "48" @default.
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- W2009273046 abstract "The inositol-1,4,5-trisphosphate receptors (InsP3Rs) are the major intracellular Ca2+-release channels in cells. Activity of InsP3Rs is essential for elementary and global Ca2+ events in the cell. There are three InsP3Rs isoforms that are present in mammalian cells. In this review we will focus primarily on InsP3R type 1. The InsP3R1 is a predominant isoform in neurons and it is the most extensively studied isoform. Combination of biophysical and structural methods revealed key mechanisms of InsP3R function and modulation. Cell biological and biochemical studies lead to identification of a large number of InsP3R-binding proteins. InsP3Rs are involved in the regulation of numerous physiological processes, including learning and memory, proliferation, differentiation, development and cell death. Malfunction of InsP3R1 play a role in a number of neurodegenerative disorders and other disease states. InsP3Rs represent a potentially valuable drug target for treatment of these disorders and for modulating activity of neurons and other cells. Future studies will provide better understanding of physiological functions of InsP3Rs in health and disease." @default.
- W2009273046 created "2016-06-24" @default.
- W2009273046 creator A5008443335 @default.
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- W2009273046 creator A5077482664 @default.
- W2009273046 creator A5085920090 @default.
- W2009273046 creator A5089877416 @default.
- W2009273046 date "2014-09-01" @default.
- W2009273046 modified "2023-10-18" @default.
- W2009273046 title "Intracellular calcium channels: Inositol-1,4,5-trisphosphate receptors" @default.
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