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• W2009274695 abstract "ABSTRACT The mechanism of CD4 + T-cell depletion during chronic human immunodeficiency virus type 1 (HIV-1) infection remains unknown. Many studies suggest a significant role for chronic CD4 + T-cell activation. We assumed that the pathogenic process of excessive CD4 + T-cell activation would be reflected in the transcriptional profiles of activated CD4 + T cells. Here we demonstrate that the transcriptional programs of in vivo-activated CD4 + T cells from untreated HIV-positive (HIV + ) individuals are clearly different from those of activated CD4 + T cells from HIV-negative (HIV − ) individuals. We observed a dramatic up-regulation of cell cycle-associated and interferon-stimulated transcripts in activated CD4 + T cells of untreated HIV + individuals. Furthermore, we find an enrichment of proliferative and type I interferon-responsive transcription factor binding sites in the promoters of genes that are differentially expressed in activated CD4 + T cells of untreated HIV + individuals compared to those of HIV − individuals. We confirm these findings by examination of in vivo-activated CD4 + T cells. Taken together, these results suggest that activated CD4 + T cells from untreated HIV + individuals are in a hyperproliferative state that is modulated by type I interferons. From these results, we propose a new model for CD4 + T-cell depletion during chronic HIV-1 infection." @default.
• W2009274695 created "2016-06-24" @default.
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• W2009274695 date "2008-02-15" @default.
• W2009274695 modified "2023-09-26" @default.
• W2009274695 title "Chronic CD4 ⁺ T-Cell Activation and Depletion in Human Immunodeficiency Virus Type 1 Infection: Type I Interferon-Mediated Disruption of T-Cell Dynamics" @default.
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• W2009274695 doi "https://doi.org/10.1128/jvi.02228-07" @default.
• W2009274695 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2258719" @default.
• W2009274695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18077723" @default.
• W2009274695 hasPublicationYear "2008" @default.
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