FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009278311> ?p ?o ?g. }

• W2009278311 endingPage "764" @default.
• W2009278311 startingPage "758" @default.
• W2009278311 abstract "Most medications prescribed for attention-deficit-hyperactivity disorder are psychomotor stimulants with reinforcing effects in laboratory animals (eg methylphenidate). The present studies were conducted to evaluate the reinforcing effects of the recently approved medication atomoxetine in monkeys trained to 'choose' between automated deliveries of either an i.v. injection or food. Rhesus monkeys were trained to lever-press under concurrent schedules of reinforcement; responses on one lever resulted in an injection of either saline or drug, and responses on the alternative lever resulted in food delivery. Data were collected on four measures: response rates, percentage of total responses occurring on the injection-lever (% ILR), number of injections earned, and number of food pellets earned. Dose-effect functions were determined for cocaine (0.003-0.3 mg/kg/inj), methylphenidate (0.003-0.1 mg/kg/inj), amphetamine (0.003-0.1 mg/kg/inj), atomoxetine (0.01-0.3 mg/kg/inj), and desipramine (0.03-1.0 mg/kg/inj) using a double alternation schedule of saline and drug availability. Results indicate that the distribution of behavior changed according to the drug and dose available for self-injection. Saline availability was typically associated with high rates of food-maintained responding. The % ILR increased from 3+/-1% when saline was available to >90% when >0.03 mg/kg/inj of cocaine, methylphenidate or d-amphetamine was available. However, no dose of atomoxetine or desipramine maintained self-administration behavior on the injection-lever. The number of food pellets earned per session decreased as the dose of each drug increased, indicative of behavioral activity with all five drugs. The reinforcing effects of cocaine, methylphenidate, and d-amphetamine in these studies are consistent with previous findings in nonhuman primates and with their documented abuse liability. The absence of reinforcing effects of atomoxetine support the view that, like desipramine, it has no evident abuse potential." @default.
• W2009278311 created "2016-06-24" @default.
• W2009278311 creator A5021753249 @default.
• W2009278311 creator A5025467970 @default.
• W2009278311 creator A5053275074 @default.
• W2009278311 creator A5085427842 @default.
• W2009278311 date "2004-11-03" @default.
• W2009278311 modified "2023-10-18" @default.
• W2009278311 title "Evaluation of the Reinforcing Effects of Monoamine Reuptake Inhibitors Under a Concurrent Schedule of Food and I.V. Drug Delivery in Rhesus Monkeys" @default.
• W2009278311 cites W1232286304 @default.
• W2009278311 cites W1635165574 @default.
• W2009278311 cites W1913907396 @default.
• W2009278311 cites W1964890792 @default.
• W2009278311 cites W1965760966 @default.
• W2009278311 cites W1971678653 @default.
• W2009278311 cites W1973062274 @default.
• W2009278311 cites W1992853415 @default.
• W2009278311 cites W2007495472 @default.
• W2009278311 cites W2024776169 @default.
• W2009278311 cites W2032755153 @default.
• W2009278311 cites W2033200028 @default.
• W2009278311 cites W2038219188 @default.
• W2009278311 cites W2040513075 @default.
• W2009278311 cites W2041016454 @default.
• W2009278311 cites W2051791048 @default.
• W2009278311 cites W2055073544 @default.
• W2009278311 cites W2057760214 @default.
• W2009278311 cites W2074689143 @default.
• W2009278311 cites W2079590493 @default.
• W2009278311 cites W2086405419 @default.
• W2009278311 cites W2095217951 @default.
• W2009278311 cites W2122518346 @default.
• W2009278311 cites W2122694895 @default.
• W2009278311 cites W2123980944 @default.
• W2009278311 cites W2140513029 @default.
• W2009278311 cites W2149148979 @default.
• W2009278311 cites W2157871211 @default.
• W2009278311 cites W2162580726 @default.
• W2009278311 cites W2323042322 @default.
• W2009278311 cites W2326916472 @default.
• W2009278311 cites W2341416615 @default.
• W2009278311 cites W3139845868 @default.
• W2009278311 cites W4296404382 @default.
• W2009278311 doi "https://doi.org/10.1038/sj.npp.1300593" @default.
• W2009278311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15526000" @default.
• W2009278311 hasPublicationYear "2004" @default.
• W2009278311 type Work @default.
• W2009278311 sameAs 2009278311 @default.
• W2009278311 citedByCount "38" @default.
• W2009278311 countsByYear W20092783112012 @default.
• W2009278311 countsByYear W20092783112013 @default.
• W2009278311 countsByYear W20092783112014 @default.
• W2009278311 countsByYear W20092783112015 @default.
• W2009278311 countsByYear W20092783112016 @default.
• W2009278311 countsByYear W20092783112019 @default.
• W2009278311 countsByYear W20092783112021 @default.
• W2009278311 countsByYear W20092783112022 @default.
• W2009278311 countsByYear W20092783112023 @default.
• W2009278311 crossrefType "journal-article" @default.
• W2009278311 hasAuthorship W2009278311A5021753249 @default.
• W2009278311 hasAuthorship W2009278311A5025467970 @default.
• W2009278311 hasAuthorship W2009278311A5053275074 @default.
• W2009278311 hasAuthorship W2009278311A5085427842 @default.
• W2009278311 hasBestOaLocation W20092783111 @default.
• W2009278311 hasConcept C118552586 @default.
• W2009278311 hasConcept C126322002 @default.
• W2009278311 hasConcept C15744967 @default.
• W2009278311 hasConcept C2777112843 @default.
• W2009278311 hasConcept C2777193897 @default.
• W2009278311 hasConcept C2777397205 @default.
• W2009278311 hasConcept C2778555786 @default.
• W2009278311 hasConcept C2778781522 @default.
• W2009278311 hasConcept C2779177272 @default.
• W2009278311 hasConcept C2780250439 @default.
• W2009278311 hasConcept C2780557958 @default.
• W2009278311 hasConcept C2780783007 @default.
• W2009278311 hasConcept C42219234 @default.
• W2009278311 hasConcept C513476851 @default.
• W2009278311 hasConcept C558461103 @default.
• W2009278311 hasConcept C71924100 @default.
• W2009278311 hasConcept C98274493 @default.
• W2009278311 hasConceptScore W2009278311C118552586 @default.
• W2009278311 hasConceptScore W2009278311C126322002 @default.
• W2009278311 hasConceptScore W2009278311C15744967 @default.
• W2009278311 hasConceptScore W2009278311C2777112843 @default.
• W2009278311 hasConceptScore W2009278311C2777193897 @default.
• W2009278311 hasConceptScore W2009278311C2777397205 @default.
• W2009278311 hasConceptScore W2009278311C2778555786 @default.
• W2009278311 hasConceptScore W2009278311C2778781522 @default.
• W2009278311 hasConceptScore W2009278311C2779177272 @default.
• W2009278311 hasConceptScore W2009278311C2780250439 @default.
• W2009278311 hasConceptScore W2009278311C2780557958 @default.
• W2009278311 hasConceptScore W2009278311C2780783007 @default.
• W2009278311 hasConceptScore W2009278311C42219234 @default.
• W2009278311 hasConceptScore W2009278311C513476851 @default.
• W2009278311 hasConceptScore W2009278311C558461103 @default.
• W2009278311 hasConceptScore W2009278311C71924100 @default.
• W2009278311 hasConceptScore W2009278311C98274493 @default.

• next