Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009289380> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2009289380 endingPage "S15" @default.
- W2009289380 startingPage "S12" @default.
- W2009289380 abstract "Bopindolol is a potent beta-adrenoceptor antagonist with mild intrinsic sympathomimetic activity that exhibits a long duration of action. The cardiac beta-adrenoceptor blockade produced by an oral dose of 1 mg bopindolol is of similar intensity as that seen after atenolol 100 mg p.o. or pindolol 10 mg p.o. Like other beta-adrenoceptor antagonists, bopindolol is effective in inhibiting resting and stimulated plasma renin activity. In contrast to compounds lacking ISA, bopindolol does not produce undesirable changes in plasma lipoprotein composition during chronic therapy. Its bioavailability after oral administration amounts to about 70%. In the studies reviewed, bopindolol was well tolerated even after an oral dose of 12 mg, which, as far as beta-adrenoceptor blockade is concerned, would be equivalent to a single oral dose of about 1.2 g of atenolol. The onset of action of bopindolol is relatively slow, a feature that to a certain extent might account for the good tolerance of the drug observed in experimental and therapeutic studies. The delayed onset of action of the drug has facilitated the elucidation of the relationship between plasma levels and pharmacological effects during the period immediately after oral administration. Analysis of the temporal relationship between drug plasma levels and beta-adrenoceptor blockade provides evidence suggesting that the cardiac beta adrenoceptors lie outside the plasma compartment." @default.
- W2009289380 created "2016-06-24" @default.
- W2009289380 creator A5000212877 @default.
- W2009289380 date "1986-01-01" @default.
- W2009289380 modified "2023-10-16" @default.
- W2009289380 title "Clinical Pharmacological Studies with the Long-Acting β-Adrenoceptor Blocking Drug Bopindolol" @default.
- W2009289380 doi "https://doi.org/10.1097/00005344-198608006-00003" @default.
- W2009289380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2439811" @default.
- W2009289380 hasPublicationYear "1986" @default.
- W2009289380 type Work @default.
- W2009289380 sameAs 2009289380 @default.
- W2009289380 citedByCount "4" @default.
- W2009289380 crossrefType "journal-article" @default.
- W2009289380 hasAuthorship W2009289380A5000212877 @default.
- W2009289380 hasBestOaLocation W20092893801 @default.
- W2009289380 hasConcept C126322002 @default.
- W2009289380 hasConcept C134018914 @default.
- W2009289380 hasConcept C138976137 @default.
- W2009289380 hasConcept C170493617 @default.
- W2009289380 hasConcept C181389837 @default.
- W2009289380 hasConcept C198710026 @default.
- W2009289380 hasConcept C2776525901 @default.
- W2009289380 hasConcept C2777056448 @default.
- W2009289380 hasConcept C2778151854 @default.
- W2009289380 hasConcept C2778468042 @default.
- W2009289380 hasConcept C2778499207 @default.
- W2009289380 hasConcept C2780035454 @default.
- W2009289380 hasConcept C2780275434 @default.
- W2009289380 hasConcept C2909341992 @default.
- W2009289380 hasConcept C46821324 @default.
- W2009289380 hasConcept C71924100 @default.
- W2009289380 hasConcept C84393581 @default.
- W2009289380 hasConcept C98274493 @default.
- W2009289380 hasConceptScore W2009289380C126322002 @default.
- W2009289380 hasConceptScore W2009289380C134018914 @default.
- W2009289380 hasConceptScore W2009289380C138976137 @default.
- W2009289380 hasConceptScore W2009289380C170493617 @default.
- W2009289380 hasConceptScore W2009289380C181389837 @default.
- W2009289380 hasConceptScore W2009289380C198710026 @default.
- W2009289380 hasConceptScore W2009289380C2776525901 @default.
- W2009289380 hasConceptScore W2009289380C2777056448 @default.
- W2009289380 hasConceptScore W2009289380C2778151854 @default.
- W2009289380 hasConceptScore W2009289380C2778468042 @default.
- W2009289380 hasConceptScore W2009289380C2778499207 @default.
- W2009289380 hasConceptScore W2009289380C2780035454 @default.
- W2009289380 hasConceptScore W2009289380C2780275434 @default.
- W2009289380 hasConceptScore W2009289380C2909341992 @default.
- W2009289380 hasConceptScore W2009289380C46821324 @default.
- W2009289380 hasConceptScore W2009289380C71924100 @default.
- W2009289380 hasConceptScore W2009289380C84393581 @default.
- W2009289380 hasConceptScore W2009289380C98274493 @default.
- W2009289380 hasIssue "Supplement 6" @default.
- W2009289380 hasLocation W20092893801 @default.
- W2009289380 hasLocation W20092893802 @default.
- W2009289380 hasLocation W20092893803 @default.
- W2009289380 hasOpenAccess W2009289380 @default.
- W2009289380 hasPrimaryLocation W20092893801 @default.
- W2009289380 hasRelatedWork W1969679839 @default.
- W2009289380 hasRelatedWork W2004881900 @default.
- W2009289380 hasRelatedWork W2014370569 @default.
- W2009289380 hasRelatedWork W2023843721 @default.
- W2009289380 hasRelatedWork W2048809612 @default.
- W2009289380 hasRelatedWork W2052460192 @default.
- W2009289380 hasRelatedWork W2170398504 @default.
- W2009289380 hasRelatedWork W2276917216 @default.
- W2009289380 hasRelatedWork W2410305287 @default.
- W2009289380 hasRelatedWork W2415066974 @default.
- W2009289380 hasVolume "8" @default.
- W2009289380 isParatext "false" @default.
- W2009289380 isRetracted "false" @default.
- W2009289380 magId "2009289380" @default.
- W2009289380 workType "article" @default.