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- W2009290143 abstract "Heart failure (HF) is the common end point of cardiac diseases. Despite the optimization of therapeutic strategies and the consequent overall reduction in HF-related mortality, the key underlying intracellular signal transduction abnormalities have not been addressed directly. In this regard, the gaps in modern HF therapy include derangement of β-adrenergic receptor (β-AR) signaling, Ca(2+) disbalances, cardiac myocyte death, diastolic dysfunction, and monogenetic cardiomyopathies. In this review we discuss the potential of gene therapy to fill these gaps and rectify abnormalities in intracellular signaling. We also examine current vector technology and currently available vector-delivery strategies, and we delineate promising gene therapy structures. Finally, we analyze potential limitations related to the transfer of successful preclinical gene therapy approaches to HF treatment in the clinic, as well as impending strategies aimed at overcoming these limitations." @default.
- W2009290143 created "2016-06-24" @default.
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- W2009290143 date "2011-08-24" @default.
- W2009290143 modified "2023-10-06" @default.
- W2009290143 title "Gene Therapy Targets in Heart Failure: The Path to Translation" @default.
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- W2009290143 cites W1977108718 @default.
- W2009290143 cites W1989463892 @default.
- W2009290143 cites W1994103758 @default.
- W2009290143 cites W2001762954 @default.
- W2009290143 cites W2007371764 @default.
- W2009290143 cites W2022628418 @default.
- W2009290143 cites W2029913374 @default.
- W2009290143 cites W2032538428 @default.
- W2009290143 cites W2037522148 @default.
- W2009290143 cites W2042961764 @default.
- W2009290143 cites W2043698693 @default.
- W2009290143 cites W2044964290 @default.
- W2009290143 cites W2048303185 @default.
- W2009290143 cites W2050824263 @default.
- W2009290143 cites W2057906587 @default.
- W2009290143 cites W2058920539 @default.
- W2009290143 cites W2064432631 @default.
- W2009290143 cites W2065503803 @default.
- W2009290143 cites W2068769204 @default.
- W2009290143 cites W2078748771 @default.
- W2009290143 cites W2084725634 @default.
- W2009290143 cites W2087863216 @default.
- W2009290143 cites W2089055579 @default.
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- W2009290143 cites W2106455193 @default.
- W2009290143 cites W2106540045 @default.
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- W2009290143 cites W2120189180 @default.
- W2009290143 cites W2121279599 @default.
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- W2009290143 cites W2130553995 @default.
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- W2009290143 cites W2138599263 @default.
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- W2009290143 cites W2139331439 @default.
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- W2009290143 doi "https://doi.org/10.1038/clpt.2011.148" @default.
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