FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009295364> ?p ?o ?g. }

• W2009295364 endingPage "1256" @default.
• W2009295364 startingPage "1249" @default.
• W2009295364 abstract "Background: Ethanol administration elevates the levels of GABAergic neuroactive steroids in brain and contributes to some of its behavioral actions. In the present study, we investigated whether such elevation of GABAergic neuroactive steroids contributes to the motor incoordinating effects of ethanol. Methods: Sprague-Dawley rats were administered ethanol (2 g/kg intraperitoneally) or saline, and the level of 3α-hydroxy-5α-pregnan-20-one (3α,5α-THP) was measured across time in cerebral cortex and in various brain regions at the peak time by radioimmunoassay. To study whether increases in GABAergic neuroactive steroids are responsible for the motor incoordinating actions of ethanol, rats were subjected to chemical (5α-reductase inhibitor, finasteride) and surgical (adrenalectomy) manipulations before receiving ethanol (2 g/kg intraperitoneally) injections. The rats were then subjected to different paradigms to evaluate motor impairment including the Majchrowicz motor intoxication rating scale, Rotarod test, and aerial righting reflex task at different time points. Results: The radioimmunoassay of 3α,5α-THP in different brain regions showed that ethanol increases 3α,5α-THP levels by 3- and 9-fold in cerebral cortex and hippocampus, respectively. There was no change in 3α,5α-THP levels in cerebellum and midbrain. The time course of 3α,5α-THP elevations in the cerebral cortex showed significant increases 20-min after ethanol injection with a peak at 60 min. In contrast, motor toxicity peaked between 5 and 10 min after ethanol injections and gradually decreased over time. Furthermore, adrenalectomy or pretreatment with finasteride (2 × 50 mg/kg, subcutaneously) did not reduce motor incoordinating effects of ethanol as assessed by the Majchrowicz intoxication rating score, Rotarod test, or aerial righting reflex task. Conclusions: Ethanol increases GABAergic neuroactive steroids in a time- and brain region-selective manner. The role of neuroactive steroids in alcohol action is specific for certain behaviors. Alcohol-induced deficits in motor coordination are not mediated by elevated neuroactive steroid biosynthesis." @default.
• W2009295364 created "2016-06-24" @default.
• W2009295364 creator A5019493322 @default.
• W2009295364 creator A5024081434 @default.
• W2009295364 creator A5049055665 @default.
• W2009295364 creator A5078670497 @default.
• W2009295364 date "2004-08-01" @default.
• W2009295364 modified "2023-09-27" @default.
• W2009295364 title "Ethanol-induced elevation of 3??-hydroxy-5??-pregnan-20-one does not modulate motor incoordination in rats" @default.
• W2009295364 cites W1482831570 @default.
• W2009295364 cites W153065932 @default.
• W2009295364 cites W1814943294 @default.
• W2009295364 cites W1922154348 @default.
• W2009295364 cites W1973649857 @default.
• W2009295364 cites W1978013837 @default.
• W2009295364 cites W1978093992 @default.
• W2009295364 cites W1983424615 @default.
• W2009295364 cites W1986566323 @default.
• W2009295364 cites W1991772069 @default.
• W2009295364 cites W1995510267 @default.
• W2009295364 cites W2000362647 @default.
• W2009295364 cites W2000645146 @default.
• W2009295364 cites W2006678207 @default.
• W2009295364 cites W2015361682 @default.
• W2009295364 cites W2019376092 @default.
• W2009295364 cites W2024350454 @default.
• W2009295364 cites W2031458111 @default.
• W2009295364 cites W2033385789 @default.
• W2009295364 cites W2035842324 @default.
• W2009295364 cites W2037725254 @default.
• W2009295364 cites W2039759850 @default.
• W2009295364 cites W2043277302 @default.
• W2009295364 cites W2044676056 @default.
• W2009295364 cites W2050844190 @default.
• W2009295364 cites W2053381331 @default.
• W2009295364 cites W2053956851 @default.
• W2009295364 cites W2058404259 @default.
• W2009295364 cites W2060586131 @default.
• W2009295364 cites W2067467266 @default.
• W2009295364 cites W2072370095 @default.
• W2009295364 cites W2093765555 @default.
• W2009295364 cites W2118773914 @default.
• W2009295364 cites W2126532122 @default.
• W2009295364 cites W4250799066 @default.
• W2009295364 doi "https://doi.org/10.1097/01.alc.0000134232.44210.06" @default.
• W2009295364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15318125" @default.
• W2009295364 hasPublicationYear "2004" @default.
• W2009295364 type Work @default.
• W2009295364 sameAs 2009295364 @default.
• W2009295364 citedByCount "24" @default.
• W2009295364 countsByYear W20092953642012 @default.
• W2009295364 countsByYear W20092953642013 @default.
• W2009295364 countsByYear W20092953642014 @default.
• W2009295364 countsByYear W20092953642020 @default.
• W2009295364 countsByYear W20092953642021 @default.
• W2009295364 crossrefType "journal-article" @default.
• W2009295364 hasAuthorship W2009295364A5019493322 @default.
• W2009295364 hasAuthorship W2009295364A5024081434 @default.
• W2009295364 hasAuthorship W2009295364A5049055665 @default.
• W2009295364 hasAuthorship W2009295364A5078670497 @default.
• W2009295364 hasConcept C126322002 @default.
• W2009295364 hasConcept C131783052 @default.
• W2009295364 hasConcept C134018914 @default.
• W2009295364 hasConcept C168258287 @default.
• W2009295364 hasConcept C170493617 @default.
• W2009295364 hasConcept C185592680 @default.
• W2009295364 hasConcept C2777397205 @default.
• W2009295364 hasConcept C2778338918 @default.
• W2009295364 hasConcept C2779177108 @default.
• W2009295364 hasConcept C2780161600 @default.
• W2009295364 hasConcept C2781161787 @default.
• W2009295364 hasConcept C42219234 @default.
• W2009295364 hasConcept C44796713 @default.
• W2009295364 hasConcept C55493867 @default.
• W2009295364 hasConcept C71924100 @default.
• W2009295364 hasConcept C83974742 @default.
• W2009295364 hasConcept C98274493 @default.
• W2009295364 hasConceptScore W2009295364C126322002 @default.
• W2009295364 hasConceptScore W2009295364C131783052 @default.
• W2009295364 hasConceptScore W2009295364C134018914 @default.
• W2009295364 hasConceptScore W2009295364C168258287 @default.
• W2009295364 hasConceptScore W2009295364C170493617 @default.
• W2009295364 hasConceptScore W2009295364C185592680 @default.
• W2009295364 hasConceptScore W2009295364C2777397205 @default.
• W2009295364 hasConceptScore W2009295364C2778338918 @default.
• W2009295364 hasConceptScore W2009295364C2779177108 @default.
• W2009295364 hasConceptScore W2009295364C2780161600 @default.
• W2009295364 hasConceptScore W2009295364C2781161787 @default.
• W2009295364 hasConceptScore W2009295364C42219234 @default.
• W2009295364 hasConceptScore W2009295364C44796713 @default.
• W2009295364 hasConceptScore W2009295364C55493867 @default.
• W2009295364 hasConceptScore W2009295364C71924100 @default.
• W2009295364 hasConceptScore W2009295364C83974742 @default.
• W2009295364 hasConceptScore W2009295364C98274493 @default.
• W2009295364 hasIssue "8" @default.
• W2009295364 hasLocation W20092953641 @default.
• W2009295364 hasLocation W20092953642 @default.
• W2009295364 hasOpenAccess W2009295364 @default.

• next