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• W2009297535 abstract "Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis, vasculogenesis and vascular permeability. Edema in glioma tumors is considered one of the most pathological characteristics, but the mechanism of regulating vascular permeability is still unclear. In the present study, tumorigenic mice were generated by subcutaneous injection of glioma cell lines, C6‐null cells and stable transfected‐C6 cells overexpressing mock vector (C6‐mock) and antisense VEGF (C6‐VEGF −/– ). Overexpression of antisense VEGF (C6‐VEGF −/– mice) significantly suppressed tumor growth, decreased angiogenesis and reduced tumoral edema. Further studies by electron microscope revealed that tumor‐induced hyperpermeability was mediated by formation of vesiculo‐vacuolar organelles (VVO), specifically reducing the number of vesicle and caveolae in VVO, and this effect was blocked, at least partially, by antisense VEGF. These data show a possible mechanism of tumor‐induced hyperpermeability and indicate that blockage of VEGF might contribute to therapeutical strategies for tumor edema. ( Cancer Sci 2008; 99: 2540–2546)" @default.
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• W2009297535 date "2008-12-01" @default.
• W2009297535 modified "2023-10-16" @default.
• W2009297535 title "Inhibition of tumor-induced edema by antisense VEGF is mediated by suppressive vesiculo-vacuolar organelles (VVO) formation" @default.
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• W2009297535 doi "https://doi.org/10.1111/j.1349-7006.2008.00974.x" @default.
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