FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009301442> ?p ?o ?g. }

• W2009301442 endingPage "983" @default.
• W2009301442 startingPage "975" @default.
• W2009301442 abstract "To explore the role of endogenous endothelin (ET) in the regulation of vascular functions, we studied the effects endothelin receptor blockade on blood pressure, plasma volume and albumin escape during endotoxin shock in conscious, chronically catheterized rats. Red blood cell volume and plasma volume were determined by using chromium‐51‐tagged erythrocytes and iodine‐125‐labelled albumin, respectively. Intravenous injection of lipopolysaccharide (LPS, 10 mg kg −1 ) resulted in hypotension, haemoconcentration, and increased total‐body albumin escape, which is reflected by a 30% reduction in plasma volume. Plasma ET‐1 concentrations increased 2.1 fold and 5.4 fold at 30 and 120 min post‐LPS, respectively. LPS‐induced losses in plasma volume and albumin escape were significantly attenuated by pretreatment of animals with the dual ET A /ET B receptor antagonist bosentan (17.4 μmol kg −1 , i.v. 15 min prior to LPS) or the ET A receptor antagonist FR 139317 (3.8 μmol kg −1 , i.v.) during both the immediate and delayed phases of endotoxin shock. The inhibitory actions of bosentan and FR 139317 were similar. Both antagonists augmented the hypotensive action of LPS. Administration of bosentan or FR 139317 70 min after injection of LPS also attenuated further losses in plasma volume and increases in total body and organ albumin escape rates with the exception of the lung and kidney. These results indicate a role for endogenous endothelin in mediating losses in plasma volume and albumin escape elicited by LPS predominantly through activation of ET A receptors, and suggest that by attenuating these events, ET A or dual ET A /ET B receptor blockers may be useful agents in the therapy of septic shock. British Journal of Pharmacology (2000) 129 , 975–983; doi: 10.1038/sj.bjp.0703114" @default.
• W2009301442 created "2016-06-24" @default.
• W2009301442 creator A5038048841 @default.
• W2009301442 date "2000-03-01" @default.
• W2009301442 modified "2023-10-04" @default.
• W2009301442 title "Role for endogenous endothelin in the regulation of plasma volume and albumin escape during endotoxin shock in conscious rats" @default.
• W2009301442 cites W1571495789 @default.
• W2009301442 cites W1982898081 @default.
• W2009301442 cites W1983184640 @default.
• W2009301442 cites W1989880738 @default.
• W2009301442 cites W1990856194 @default.
• W2009301442 cites W2001887083 @default.
• W2009301442 cites W2005872010 @default.
• W2009301442 cites W2006052946 @default.
• W2009301442 cites W2006215678 @default.
• W2009301442 cites W2006464597 @default.
• W2009301442 cites W2009758381 @default.
• W2009301442 cites W2012264084 @default.
• W2009301442 cites W2024158896 @default.
• W2009301442 cites W2024808728 @default.
• W2009301442 cites W2026785829 @default.
• W2009301442 cites W2026928385 @default.
• W2009301442 cites W2045385733 @default.
• W2009301442 cites W2048093743 @default.
• W2009301442 cites W2058621789 @default.
• W2009301442 cites W2059369537 @default.
• W2009301442 cites W2065699321 @default.
• W2009301442 cites W2067338751 @default.
• W2009301442 cites W2077962578 @default.
• W2009301442 cites W2079125213 @default.
• W2009301442 cites W2081209290 @default.
• W2009301442 cites W2088542279 @default.
• W2009301442 cites W2088858758 @default.
• W2009301442 cites W2089309879 @default.
• W2009301442 cites W2090970680 @default.
• W2009301442 cites W2125076307 @default.
• W2009301442 cites W2125471613 @default.
• W2009301442 cites W2126534770 @default.
• W2009301442 cites W2136956854 @default.
• W2009301442 cites W2171686436 @default.
• W2009301442 cites W2174992385 @default.
• W2009301442 cites W2252586061 @default.
• W2009301442 cites W2313326603 @default.
• W2009301442 cites W2336184170 @default.
• W2009301442 doi "https://doi.org/10.1038/sj.bjp.0703114" @default.
• W2009301442 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1571901" @default.
• W2009301442 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10696098" @default.
• W2009301442 hasPublicationYear "2000" @default.
• W2009301442 type Work @default.
• W2009301442 sameAs 2009301442 @default.
• W2009301442 citedByCount "25" @default.
• W2009301442 countsByYear W20093014422012 @default.
• W2009301442 countsByYear W20093014422013 @default.
• W2009301442 countsByYear W20093014422014 @default.
• W2009301442 countsByYear W20093014422015 @default.
• W2009301442 countsByYear W20093014422016 @default.
• W2009301442 countsByYear W20093014422017 @default.
• W2009301442 countsByYear W20093014422020 @default.
• W2009301442 crossrefType "journal-article" @default.
• W2009301442 hasAuthorship W2009301442A5038048841 @default.
• W2009301442 hasBestOaLocation W20093014421 @default.
• W2009301442 hasConcept C126322002 @default.
• W2009301442 hasConcept C134018914 @default.
• W2009301442 hasConcept C144980905 @default.
• W2009301442 hasConcept C16613235 @default.
• W2009301442 hasConcept C170493617 @default.
• W2009301442 hasConcept C185592680 @default.
• W2009301442 hasConcept C2776125364 @default.
• W2009301442 hasConcept C2776345702 @default.
• W2009301442 hasConcept C2781109936 @default.
• W2009301442 hasConcept C2781300812 @default.
• W2009301442 hasConcept C71924100 @default.
• W2009301442 hasConceptScore W2009301442C126322002 @default.
• W2009301442 hasConceptScore W2009301442C134018914 @default.
• W2009301442 hasConceptScore W2009301442C144980905 @default.
• W2009301442 hasConceptScore W2009301442C16613235 @default.
• W2009301442 hasConceptScore W2009301442C170493617 @default.
• W2009301442 hasConceptScore W2009301442C185592680 @default.
• W2009301442 hasConceptScore W2009301442C2776125364 @default.
• W2009301442 hasConceptScore W2009301442C2776345702 @default.
• W2009301442 hasConceptScore W2009301442C2781109936 @default.
• W2009301442 hasConceptScore W2009301442C2781300812 @default.
• W2009301442 hasConceptScore W2009301442C71924100 @default.
• W2009301442 hasIssue "5" @default.
• W2009301442 hasLocation W20093014421 @default.
• W2009301442 hasLocation W20093014422 @default.
• W2009301442 hasLocation W20093014423 @default.
• W2009301442 hasLocation W20093014424 @default.
• W2009301442 hasOpenAccess W2009301442 @default.
• W2009301442 hasPrimaryLocation W20093014421 @default.
• W2009301442 hasRelatedWork W1970739379 @default.
• W2009301442 hasRelatedWork W1986060795 @default.
• W2009301442 hasRelatedWork W2027748287 @default.
• W2009301442 hasRelatedWork W2034583712 @default.
• W2009301442 hasRelatedWork W2063619316 @default.
• W2009301442 hasRelatedWork W2086825515 @default.
• W2009301442 hasRelatedWork W2088508460 @default.
• W2009301442 hasRelatedWork W2153915731 @default.

• next