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- W2009328029 abstract "This study aimed to investigate the potential for flavonoid action at A(1) adenosine receptors in vitro. In a radioligand binding assay for A(1) adenosine receptor occupancy in particulate preparations from guinea-pig cerebral cortex, flavonoids competed in concentration-dependent manners with Hill slopes typically not different from unity. Of the flavonoids tested, quercetin showed highest affinity (pKi value of 5.33). At a concentration of 28 mm, quercetin evoked a rightward shift in the N(6)-cyclopentyladenosine-induced inhibition of electrically evoked contractions of the guinea-pig isolated ileum, allowing the calculation of a pK(i) value of 4.71. These data suggest, therefore, that flavonoids represent an additional dietary source of A(1) adenosine receptor antagonists (beyond the methylxanthines, caffeine and theophylline)." @default.
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- W2009328029 date "2006-01-01" @default.
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- W2009328029 title "Flavonoids as antagonists at A1 adenosine receptors" @default.
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- W2009328029 doi "https://doi.org/10.1002/ptr.1975" @default.
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