Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009330412> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2009330412 endingPage "1361" @default.
- W2009330412 startingPage "1351" @default.
- W2009330412 abstract "Metabolic studies of bithionol sulfoxide using labeled compounds were carried out in rats. It was found that bithionol sulfoxide was not only oxidized to bithionol sulfone but also reduced to bithionol (sulfide). The metabolic fate of bithionol sulfone was greatly different from that of bithionol. Bithionol sulfone was excreted mainly in urine as 3, 5-dichloro-2-hydroxyphenylsulfonic acid, whereas bithionol was excreted mainly in bile as a glucuronide conjugate. The presence of 3,5-dichloro-2-hydroxyphenylsulfonic acid and inorganic sulfate was demonstrated in the urine of rats given bithionol sulfoxide. It was assumed that 3,5-dichloro-2-hydroxyphenylsulfonic acid was formed by the cleavage of the C-S bond of bithionol sulfone molecule and that inorganic sulfate was produced by the cleavage of the C-S bond of bithionol sulfoxide molecule. Metabolic study using 3H-bis(2-hydroxy-phenyl)-sulfone suggested that catechol was formed together with sulfonic acid by the cleavage of the C-S bond of bithionol sulfone. It is considered from the above results that the metabolic fate of bithionol sulfoxide consists of 3 different pathways: the first is reduction of bithionol sulfoxide to bithionol (sulfide); the second is oxidation of bithionol sulfoxide to bithionol sulfone; and the third is cleavage of the C-S bond of bithionol sulfoxide." @default.
- W2009330412 created "2016-06-24" @default.
- W2009330412 creator A5048821605 @default.
- W2009330412 creator A5053394771 @default.
- W2009330412 creator A5083185075 @default.
- W2009330412 date "1970-04-01" @default.
- W2009330412 modified "2023-09-25" @default.
- W2009330412 title "Metabolic fate of bis(3,5-dichloro-2-hydroxyphenyl)-sulfoxide (bithionol sulfoxide)" @default.
- W2009330412 cites W1511238795 @default.
- W2009330412 cites W1543624067 @default.
- W2009330412 cites W1543785183 @default.
- W2009330412 cites W1551173912 @default.
- W2009330412 cites W1808637054 @default.
- W2009330412 cites W2001593157 @default.
- W2009330412 cites W2028304395 @default.
- W2009330412 cites W2042417845 @default.
- W2009330412 cites W2050169783 @default.
- W2009330412 cites W2077588681 @default.
- W2009330412 cites W2080637730 @default.
- W2009330412 cites W2084362031 @default.
- W2009330412 cites W2160668938 @default.
- W2009330412 cites W2313808127 @default.
- W2009330412 cites W2321320337 @default.
- W2009330412 cites W2331172234 @default.
- W2009330412 cites W4250139995 @default.
- W2009330412 doi "https://doi.org/10.1016/0006-2952(70)90050-x" @default.
- W2009330412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5513925" @default.
- W2009330412 hasPublicationYear "1970" @default.
- W2009330412 type Work @default.
- W2009330412 sameAs 2009330412 @default.
- W2009330412 citedByCount "17" @default.
- W2009330412 countsByYear W20093304122012 @default.
- W2009330412 countsByYear W20093304122019 @default.
- W2009330412 crossrefType "journal-article" @default.
- W2009330412 hasAuthorship W2009330412A5048821605 @default.
- W2009330412 hasAuthorship W2009330412A5053394771 @default.
- W2009330412 hasAuthorship W2009330412A5083185075 @default.
- W2009330412 hasConcept C178790620 @default.
- W2009330412 hasConcept C185592680 @default.
- W2009330412 hasConcept C2778448320 @default.
- W2009330412 hasConcept C2778452553 @default.
- W2009330412 hasConcept C2778806918 @default.
- W2009330412 hasConceptScore W2009330412C178790620 @default.
- W2009330412 hasConceptScore W2009330412C185592680 @default.
- W2009330412 hasConceptScore W2009330412C2778448320 @default.
- W2009330412 hasConceptScore W2009330412C2778452553 @default.
- W2009330412 hasConceptScore W2009330412C2778806918 @default.
- W2009330412 hasIssue "4" @default.
- W2009330412 hasLocation W20093304121 @default.
- W2009330412 hasLocation W20093304122 @default.
- W2009330412 hasOpenAccess W2009330412 @default.
- W2009330412 hasPrimaryLocation W20093304121 @default.
- W2009330412 hasRelatedWork W1495044184 @default.
- W2009330412 hasRelatedWork W1922461306 @default.
- W2009330412 hasRelatedWork W2046071530 @default.
- W2009330412 hasRelatedWork W2055586081 @default.
- W2009330412 hasRelatedWork W2058125811 @default.
- W2009330412 hasRelatedWork W2178733294 @default.
- W2009330412 hasRelatedWork W2950239199 @default.
- W2009330412 hasRelatedWork W2950560315 @default.
- W2009330412 hasRelatedWork W3004582800 @default.
- W2009330412 hasRelatedWork W2522919046 @default.
- W2009330412 hasVolume "19" @default.
- W2009330412 isParatext "false" @default.
- W2009330412 isRetracted "false" @default.
- W2009330412 magId "2009330412" @default.
- W2009330412 workType "article" @default.