Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009331092> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2009331092 endingPage "628" @default.
- W2009331092 startingPage "622" @default.
- W2009331092 abstract "Adenylate cyclase activity in the myocardium and aorta of Grollman one-kidney renal hypertensive rats (RHR) and sham-operated control rats was compared. The experimental rats revealed significantly higher blood pressure and cardiac hypertrophy 6–8 weeks postoperation as compared to controls. Basal, guanine nucleotide-, fluoride-, and isoproterenol-stimulated adenylate cyclase activities were consistently decreased in the myocardium of RHR as compared to control rats. Similar changes were observed in aorta of RHR; however, the magnitude of difference was greater in aorta as compared to myocardium. The kinetic properties of enzyme with regard to the Ka (quantity of agonist required for half-maximal stimulation of adenylate cyclase) values for GTP, Gpp(NH)p, and GTP-γ-S in the absence and presence of iso-proterenol and the Ka values for iso-proterenol in the presence of GTP, Gpp(NH)p, or GTP-γ-S were comparable in RHR and control rats. However, Vmax of adenylate cyclase stimulation by guanine nucleotides, isoproterenol, and fluoride was reduced in RHR as compared to control rats. No differences between RHR and control rat myocardial membranes were observed in the affinity of [3H]DHA binding. However, the number of binding sites was reduced 20–25% in RHR as compared to control rats. These data would suggest that the number of receptor-cyclase complexes may be reduced in the RHR." @default.
- W2009331092 created "2016-06-24" @default.
- W2009331092 creator A5044671472 @default.
- W2009331092 creator A5050771541 @default.
- W2009331092 creator A5073238452 @default.
- W2009331092 creator A5083429331 @default.
- W2009331092 date "1982-07-01" @default.
- W2009331092 modified "2023-10-11" @default.
- W2009331092 title "Properties of Adenylate Cyclase in the Cardiovascular Tissues of Renal Hypertensive Rats" @default.
- W2009331092 doi "https://doi.org/10.1097/00005344-198207000-00014" @default.
- W2009331092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6181337" @default.
- W2009331092 hasPublicationYear "1982" @default.
- W2009331092 type Work @default.
- W2009331092 sameAs 2009331092 @default.
- W2009331092 citedByCount "12" @default.
- W2009331092 crossrefType "journal-article" @default.
- W2009331092 hasAuthorship W2009331092A5044671472 @default.
- W2009331092 hasAuthorship W2009331092A5050771541 @default.
- W2009331092 hasAuthorship W2009331092A5073238452 @default.
- W2009331092 hasAuthorship W2009331092A5083429331 @default.
- W2009331092 hasBestOaLocation W20093310921 @default.
- W2009331092 hasConcept C118716 @default.
- W2009331092 hasConcept C126322002 @default.
- W2009331092 hasConcept C134018914 @default.
- W2009331092 hasConcept C170493617 @default.
- W2009331092 hasConcept C180526460 @default.
- W2009331092 hasConcept C181199279 @default.
- W2009331092 hasConcept C185592680 @default.
- W2009331092 hasConcept C24998067 @default.
- W2009331092 hasConcept C2778938600 @default.
- W2009331092 hasConcept C2779980429 @default.
- W2009331092 hasConcept C2780069284 @default.
- W2009331092 hasConcept C55493867 @default.
- W2009331092 hasConcept C71924100 @default.
- W2009331092 hasConcept C86803240 @default.
- W2009331092 hasConceptScore W2009331092C118716 @default.
- W2009331092 hasConceptScore W2009331092C126322002 @default.
- W2009331092 hasConceptScore W2009331092C134018914 @default.
- W2009331092 hasConceptScore W2009331092C170493617 @default.
- W2009331092 hasConceptScore W2009331092C180526460 @default.
- W2009331092 hasConceptScore W2009331092C181199279 @default.
- W2009331092 hasConceptScore W2009331092C185592680 @default.
- W2009331092 hasConceptScore W2009331092C24998067 @default.
- W2009331092 hasConceptScore W2009331092C2778938600 @default.
- W2009331092 hasConceptScore W2009331092C2779980429 @default.
- W2009331092 hasConceptScore W2009331092C2780069284 @default.
- W2009331092 hasConceptScore W2009331092C55493867 @default.
- W2009331092 hasConceptScore W2009331092C71924100 @default.
- W2009331092 hasConceptScore W2009331092C86803240 @default.
- W2009331092 hasIssue "4" @default.
- W2009331092 hasLocation W20093310921 @default.
- W2009331092 hasLocation W20093310922 @default.
- W2009331092 hasOpenAccess W2009331092 @default.
- W2009331092 hasPrimaryLocation W20093310921 @default.
- W2009331092 hasRelatedWork W180243494 @default.
- W2009331092 hasRelatedWork W1982017426 @default.
- W2009331092 hasRelatedWork W1983113419 @default.
- W2009331092 hasRelatedWork W2002825170 @default.
- W2009331092 hasRelatedWork W2016484704 @default.
- W2009331092 hasRelatedWork W2045899126 @default.
- W2009331092 hasRelatedWork W2053922838 @default.
- W2009331092 hasRelatedWork W2464576936 @default.
- W2009331092 hasRelatedWork W269806918 @default.
- W2009331092 hasRelatedWork W3103481565 @default.
- W2009331092 hasVolume "4" @default.
- W2009331092 isParatext "false" @default.
- W2009331092 isRetracted "false" @default.
- W2009331092 magId "2009331092" @default.
- W2009331092 workType "article" @default.