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• W2009334457 abstract "I n the present study the function of the neutrophil, which exerts a major role in protection against bacterial infections, was assessed in patients with a family history of diabetes mellitus and severe periodontitis. The neutrophil chemotactic function of two groups of patients was compared, both exhibited severe periodontitis. One group had a family history of diabetes and is therefore classified as individuals with potential for abnormal glucose tolerance (Pot‐AGT Group). The other group had comparable levels of severe periodontal disease but did not have a family history of diabetes. Neither group showed evidence of systemic disease as assessed by an extensive medical history and a battery of clinical laboratory tests including CBC, SMA‐12, prothrombin time, urinalysis and glycosylated hemoglobin levels. The peripheral blood neutrophil chemotactic response of patients in both groups was measured using Boyden chambers charged with the standard chemotactic agents; endotoxin activated serum, E. coli culture supernate and formylmethionylleucylphenylalanine (FMLP), a synthetic chemotactic agent. Patients in both groups were compared on a day‐to‐day basis to systemically and periodontally healthy, age and sex matched controls. Thirteen of the 24 patients in the Pot‐AGT Group exhibited depressed neutrophil chemotaxis. In contrast, neutrophil chemotaxis was either normal or elevated in 19 of 20 patients who had no family history of diabetes, but had severe periodontal disease. One in this group showed depressed chemotaxis. The difference in neutrophil chemotactic function between these two groups was significant at the P < 0.001 level. Hence, the relationship of a positive family history of diabetes and depressed neutrophil chemotaxis was demonstrated. These results support the concept that in subjects with depressed neutrophil function or numbers, severe periodontitis is likely to be seen. These results also raise the possibility that among individuals with adult periodontitis there may be heterogeneity; some may have an underlying host protective dysfunction such as depressed neutrophil chemotactic activity which predisposes them to more severe periodontal disease. Other adults may have normal neutrophil chemotaxis and still have severe periodontal disease which may result from factors such as long term exposure to more virulent periodontopathic organisms, or they may be afflicted with some, as yet undefined, host protective abnormality." @default.
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• W2009334457 date "1981-04-01" @default.
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• W2009334457 title "Neutrophil Chemotaxis in Individuals With Advanced Periodontal Disease and a Genetic Predisposition to Diabetes Mellitus" @default.
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• W2009334457 doi "https://doi.org/10.1902/jop.1981.52.4.167" @default.
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