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• W2009336765 abstract "No AccessJournal of UrologyInvestigative Urology1 Aug 1995Urodynamic Effects of Intravesical Resiniferatoxin and Capsaicin in Conscious Rats With and Without Outflow Obstruction Osamu Ishizuka, Anders Mattiasson, and Karl-Erik* Andersson Osamu IshizukaOsamu Ishizuka More articles by this author , Anders MattiassonAnders Mattiasson More articles by this author , and Karl-Erik* AnderssonKarl-Erik* Andersson More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)67121-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The urodynamic effects of intravesical resiniferatoxin and capsaicin were investigated in rats. Materials and Methods: Continuous cystometry was performed in conscious, female Sprague-Dawley rats with and without outflow obstruction. Results: Intravesical instillation of resiniferatoxin facilitated micturition. The potency of the drug was approximately 1,000 times higher than that of capsaicin. Repeated instillations of resiniferatoxin for 6 consecutive days caused desensitization to resiniferatoxin. This was not found with repeated instillations of capsaicin. Capsaicin was also effective in rats with bladder hypertrophy, while resiniferatoxin was not. Conclusions: The findings suggest that resiniferatoxin can induce desensitization of vanilloid receptor-mediated release of tachykinins in the rat urinary bladder and that intravesical resiniferatoxin would be an interesting alternative to intravesical capsaicin in the treatment of selected cases of bladder hypersensitivity/hyperactivity. References 1 : The role of peptides in the regulation of the micturition reflex: an update. Gen. Pharmacol.1991; 22: 1. Google Scholar 2 : Capsaicin-induced bladder hyperactivity in normal conscious rats. J. Urol.1994; 152: 525. 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Google Scholar Departments of Urology and Clinical Pharmacology, Lund University Hospital, Lund, Sweden.© 1995 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byCharrua A, Cruz C, Narayanan S, Gharat L, Gullapalli S, Cruz F and Avelino A (2008) GRC-6211, a New Oral Specific TRPV1 Antagonist, Decreases Bladder Overactivity and Noxious Bladder Input in Cystitis Animal ModelsJournal of Urology, VOL. 181, NO. 1, (379-386), Online publication date: 1-Jan-2009.Saitoh C, Chancellor M, de Groat W and Yoshimura N (2007) Effects of Intravesical Instillation of Resiniferatoxin on Bladder Function and Nociceptive Behavior in Freely Moving, Conscious RatsJournal of Urology, VOL. 179, NO. 1, (359-364), Online publication date: 1-Jan-2008.Sasaki K, Chancellor M, Phelan M, Yokoyama T, Fraser M, Seki S, Kubo K, Kumon H, Groat W and Yoshimura N (2018) Diabetic Cystopathy Correlates With a Long-Term Decrease in Nerve Growth Factor Levels in The Bladder and Lumbosacral Dorsal Root GangliaJournal of Urology, VOL. 168, NO. 3, (1259-1264), Online publication date: 1-Sep-2002.ABDEL-GAWAD M, DION S and ELHILALI M (2018) EVIDENCE OF A PERIPHERAL ROLE OF NEUROKININS IN DETRUSOR HYPERREFLEXIA: A FURTHER STUDY OF SELECTIVE TACHYKININ ANTAGONISTS IN CHRONIC SPINAL INJURED RATSJournal of Urology, VOL. 165, NO. 5, (1739-1744), Online publication date: 1-May-2001.CHANCELLOR M and de GROAT W (2018) INTRAVESICAL CAPSAICIN AND RESINIFERATOXIN THERAPY: SPICING UP THE WAYS TO TREAT THE OVERACTIVE BLADDERJournal of Urology, VOL. 162, NO. 1, (3-11), Online publication date: 1-Jul-1999.KOMIYAMA I, IGAWA Y, ISHIZUKA O, NISHIZAWA O and ANDERSSON K (2018) EFFECTS OF INTRAVESICAL CAPSAICIN AND RESINIFERATOXIN ON DISTENSION-INDUCED BLADDER CONTRACTION IN CONSCIOUS RATS WITH AND WITHOUT CHRONIC SPINAL CORD INJURYJournal of Urology, VOL. 161, NO. 1, (314-319), Online publication date: 1-Jan-1999.Lazzeri M, Beneforti P and Turini D (2018) URODYNAMIC EFFECTS OF INTRAVESICAL RESINIFERATOXIN IN HUMANS: PRELIMINARY RESULTS IN STABLE AND UNSTABLE DETRUSORJournal of Urology, VOL. 158, NO. 6, (2093-2096), Online publication date: 1-Dec-1997. Volume 154Issue 2August 1995Page: 611-616 Advertisement Copyright & Permissions© 1995 by American Urological Association, Inc.MetricsAuthor Information Osamu Ishizuka More articles by this author Anders Mattiasson More articles by this author Karl-Erik* Andersson More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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