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- W2009340557 abstract "Mitochondria are responsible for a series of metabolic functions. Superoxide leakage from the respiratory chain and the resulting cascade of reactive oxygen species-induced damage, as well as mitochondrial metabolism in programmed cell death, have been intensively studied during ageing in single-cellular and higher organisms. Changes in mitochondrial physiology and metabolism resulting in ROS are thus considered to be hallmarks of ageing. In this review, we address 'other' metabolic activities of mitochondria, carbon metabolism (the TCA cycle and related underground metabolism), the synthesis of Fe/S clusters and the metabolic consequences of mitophagy. These important mitochondrial activities are hitherto less well-studied in the context of cellular and organismic ageing. In budding yeast, they strongly influence replicative, chronological and hibernating lifespan, connecting the diverse ageing phenotypes studied in this single-cellular model organism. Moreover, there is evidence that similar processes equally contribute to ageing of higher organisms as well. In this scenario, increasing loss of metabolic integrity would be one driving force that contributes to the ageing process. Understanding mitochondrial metabolism may thus be required for achieving a unifying theory of eukaryotic ageing." @default.
- W2009340557 created "2016-06-24" @default.
- W2009340557 creator A5002027299 @default.
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- W2009340557 creator A5046636813 @default.
- W2009340557 creator A5054841125 @default.
- W2009340557 creator A5070892021 @default.
- W2009340557 date "2014-01-16" @default.
- W2009340557 modified "2023-09-27" @default.
- W2009340557 title "Mitochondria in ageing: there is metabolism beyond the ROS" @default.
- W2009340557 cites W1485116839 @default.
- W2009340557 cites W1522890520 @default.
- W2009340557 cites W1544860636 @default.
- W2009340557 cites W1557863639 @default.
- W2009340557 cites W1767268379 @default.
- W2009340557 cites W1922466054 @default.
- W2009340557 cites W1939577241 @default.
- W2009340557 cites W1940436875 @default.
- W2009340557 cites W1963577160 @default.
- W2009340557 cites W1965212282 @default.
- W2009340557 cites W1965707131 @default.
- W2009340557 cites W1967604909 @default.
- W2009340557 cites W1968016394 @default.
- W2009340557 cites W1969134768 @default.
- W2009340557 cites W1970998722 @default.
- W2009340557 cites W1976812199 @default.
- W2009340557 cites W1978342871 @default.
- W2009340557 cites W1981789085 @default.
- W2009340557 cites W1982520634 @default.
- W2009340557 cites W1983338479 @default.
- W2009340557 cites W1989812133 @default.
- W2009340557 cites W1989965161 @default.
- W2009340557 cites W1996991121 @default.
- W2009340557 cites W1999477136 @default.
- W2009340557 cites W2004147608 @default.
- W2009340557 cites W2004356308 @default.
- W2009340557 cites W2011580247 @default.
- W2009340557 cites W2013936759 @default.
- W2009340557 cites W2014320780 @default.
- W2009340557 cites W2014459126 @default.
- W2009340557 cites W2018202198 @default.
- W2009340557 cites W2018694503 @default.
- W2009340557 cites W2019355685 @default.
- W2009340557 cites W2019637022 @default.
- W2009340557 cites W2020782079 @default.
- W2009340557 cites W2022852477 @default.
- W2009340557 cites W2023769035 @default.
- W2009340557 cites W2024782183 @default.
- W2009340557 cites W2029401533 @default.
- W2009340557 cites W2030605235 @default.
- W2009340557 cites W2030797472 @default.
- W2009340557 cites W2033062319 @default.
- W2009340557 cites W2035564874 @default.
- W2009340557 cites W2036083342 @default.
- W2009340557 cites W2037526941 @default.
- W2009340557 cites W2037612627 @default.
- W2009340557 cites W2037703797 @default.
- W2009340557 cites W2042367738 @default.
- W2009340557 cites W2042901701 @default.
- W2009340557 cites W2043959828 @default.
- W2009340557 cites W2044287438 @default.
- W2009340557 cites W2044897807 @default.
- W2009340557 cites W2045459244 @default.
- W2009340557 cites W2045611938 @default.
- W2009340557 cites W2046351190 @default.
- W2009340557 cites W2048340436 @default.
- W2009340557 cites W2051554319 @default.
- W2009340557 cites W2052314999 @default.
- W2009340557 cites W2057147625 @default.
- W2009340557 cites W2057385026 @default.
- W2009340557 cites W2058096429 @default.
- W2009340557 cites W2062776142 @default.
- W2009340557 cites W2063616227 @default.
- W2009340557 cites W2065298495 @default.
- W2009340557 cites W2066687327 @default.
- W2009340557 cites W2067367340 @default.
- W2009340557 cites W2068337326 @default.
- W2009340557 cites W2068700852 @default.
- W2009340557 cites W2075612822 @default.
- W2009340557 cites W2084161922 @default.
- W2009340557 cites W2084712319 @default.
- W2009340557 cites W2084825928 @default.
- W2009340557 cites W2085248094 @default.
- W2009340557 cites W2085396235 @default.
- W2009340557 cites W2089092666 @default.
- W2009340557 cites W2089502937 @default.
- W2009340557 cites W2089897141 @default.
- W2009340557 cites W2092587339 @default.
- W2009340557 cites W2093521208 @default.
- W2009340557 cites W2095217602 @default.
- W2009340557 cites W2096308293 @default.
- W2009340557 cites W2100674704 @default.
- W2009340557 cites W2101769226 @default.
- W2009340557 cites W2104047392 @default.
- W2009340557 cites W2107196479 @default.
- W2009340557 cites W2108283569 @default.