FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009348501> ?p ?o ?g. }

• W2009348501 endingPage "750" @default.
• W2009348501 startingPage "749" @default.
• W2009348501 abstract "The obstruction of blood flow from the head, neck, and arms through the superior vena cava (SVC) results in the SVC syndrome, which can lead to life-threatening complications such as circulatory failure, venous infarcts of the brain, and laryngeal and cerebral edema.1Baker GL Barnes HJ. Superior vena cava syndrome: etiology, diagnosis, and treatment.Am J Crit Care. 1992; 1: 54-64PubMed Google Scholar Most cases of SVC syndrome are due to inoperable malignant tumors, such as lung cancer (80%) and mediastinal lymphomas (15%). SVC syndrome caused by leiomyosarcoma of the SVC has previously been reported.2Weiss KS Zidar BL Wang S Magovern Sr, GJ Raju RN Lupetin AR et al.Radiation-induced leiomyosarcoma of the great vessels presenting as superior vena cava syndrome.Cancer. 1987; 60: 1238-1242Crossref PubMed Scopus (21) Google Scholar, 3Tovar-Martin E Tovar-Pardo AE Marini M Pimentel Y Rois JM. Intraluminal leiomyosarcoma of the superior vena cava: a cause of superior vena cava syndrome.J Cardiovasc Surg (Torino). 1997; 38: 33-35PubMed Google Scholar This article describes a unique case of SVC syndrome caused by pulmonary artery leiomyosarcoma, a rare and highly lethal tumor.4Mazzucco A Luciani GB Bertolini P Faggian G Morando G Ghimenton C. Primary leiomyosarcoma of the pulmonary artery: diagnostic and surgical implications.Ann Thorac Surg. 1994; 57: 222-225Abstract Full Text PDF PubMed Scopus (24) Google Scholar After treatment with radiation and chemotherapy, the tumor was successfully resected and the patient remains well 12 months later. A 51-year-old white woman was referred to this hospital for management of SVC syndrome. Fourteen months earlier she had sought treatment at another hospital for acute shortness of breath. A pulmonary angiogram at that time showed complete obstruction of blood flow in the pulmonary artery supplying the right lower lobe, and the patient received streptokinase and heparin followed by warfarin. There was no evidence of deep venous thrombosis, and neither mammography nor abdominal computed tomography (CT) indicated malignant disease. Three months later, a follow-up thoracic CT scan demonstrated a persistent filling defect in the right lower lobe pulmonary artery. Four days before admission, facial swelling and plethora developed. On the day of admission, the patient had nausea and headaches. She worked as a secretary and did not drink or smoke. Her medications included an oral contraceptive pill and warfarin. Physical examination revealed an ill-looking woman in mild respiratory distress. Her pulse rate was 96 beats/min, blood pressure 120/80 mm Hg, temperature 36.5°C, and respiratory rate 18 breaths/min. The face, neck, and arms were red and swollen, and veins in the chest, neck, and face were dilated. The trachea was in the midline and there was no evidence of goiter or a neck mass. The heart sounds were normal and the lungs were clear to auscultation and percussion. There were no abdominal masses and no leg edema. Arterial blood gas values were within normal limits. A chest radiograph demonstrated a bulky tumor in the hilum of the right lung and a small right pleural effusion. Thoracic magnetic resonance imaging revealed a large (8 × 5 × 5 cm) well-circumscribed mass at the right hilum, surrounding the bronchus intermedius, right main stem bronchus, and right lower lobe bronchus (Fig 1). The tumor arose from the right pulmonary artery, extended proximally almost to the bifurcation of the main pulmonary artery, narrowed the SVC, and indented the roof of the left atrium. Examination with a fiberoptic bronchoscope revealed extrinsic compression of the right main stem bronchus but no endobronchial lesion. CT-directed fine needle aspiration biopsy of the mass yielded pleomorphic malignant cells with prominent nucleoli and eosinophilic cytoplasmic globules. Immunohistochemical reactivity against desmin and smooth muscle actin confirmed smooth muscle differentiation, with absence of staining for epithelial, melanocytic, hematolymphoid, and vascular markers. A diagnosis of pulmonary artery leiomyosarcoma was made. The patient underwent radiation therapy (4500 Gy) followed by 3 cycles of ifosfamide (2500 mg/day for 3 days), dacarbazine (490 mg/day for 3 days), and mesna (1000 mg/day for 4 days). Within 3 days of treatment the symptoms of SVC syndrome had resolved, and within 4 weeks a second CT scan showed that the tumor had shrunk to half its previous size. Three months after presentation, a right pneumonectomy was performed with resection of a predominantly necrotic tumor, which involved the pulmonary artery, extended into the lung, and surrounded the right main stem bronchus (Fig 2). The tumor encased the right superior pulmonary vein, and a cuff of left atrium was removed with the lung. Cardiopulmonary bypass was available for the procedure but was not necessary. Frozen section analysis of the resection margin showed no tumor. On histologic examination of the resected specimen, only a microscopic focus of viable tumor was found. The tissues within the pulmonary artery lumen consisted of necrotic tumor, granulation tissue, fibrosis, and macrophages indicative of treated leiomyosarcoma. The patient made a full recovery from the pneumonectomy and remains well 12 months later. Primary pulmonary artery leiomyosarcoma is a rare and highly lethal disease. Although SVC syndrome caused by intraluminal leiomyosarcoma of the SVC has previously been reported,2Weiss KS Zidar BL Wang S Magovern Sr, GJ Raju RN Lupetin AR et al.Radiation-induced leiomyosarcoma of the great vessels presenting as superior vena cava syndrome.Cancer. 1987; 60: 1238-1242Crossref PubMed Scopus (21) Google Scholar, 3Tovar-Martin E Tovar-Pardo AE Marini M Pimentel Y Rois JM. Intraluminal leiomyosarcoma of the superior vena cava: a cause of superior vena cava syndrome.J Cardiovasc Surg (Torino). 1997; 38: 33-35PubMed Google Scholar to our knowledge this is a unique case of SVC syndrome caused by pulmonary artery leiomyosarcoma. Several cases of leiomyosarcoma of the pulmonary artery have been described in which the clinical presentation mimics that of massive or chronic pulmonary embolism.1Baker GL Barnes HJ. Superior vena cava syndrome: etiology, diagnosis, and treatment.Am J Crit Care. 1992; 1: 54-64PubMed Google Scholar, 5de Smet JM Dieudonne P Contu E Le Clerc JL Goffin Y de Boelpape C. Pulmonary artery leiomyosarcoma treated surgically.Thorac Cardiovasc Surg. 1986; 34: 98-99Crossref PubMed Scopus (10) Google Scholar Pulmonary artery leiomyosarcoma may lead to syncope and sudden death, and the diagnosis is therefore often made at thoracotomy or at autopsy.1Baker GL Barnes HJ. Superior vena cava syndrome: etiology, diagnosis, and treatment.Am J Crit Care. 1992; 1: 54-64PubMed Google Scholar Radical surgical excision offers the only hope of cure for those with early, resectable lesions.5de Smet JM Dieudonne P Contu E Le Clerc JL Goffin Y de Boelpape C. Pulmonary artery leiomyosarcoma treated surgically.Thorac Cardiovasc Surg. 1986; 34: 98-99Crossref PubMed Scopus (10) Google Scholar Successful treatment options for SVC syndrome include thrombolysis, endovascular stent placement, radiotherapy, and transluminal angioplasty, but the choice of therapy should be directed toward treatment of the underlying cause, in addition to alleviating symptoms.1Baker GL Barnes HJ. Superior vena cava syndrome: etiology, diagnosis, and treatment.Am J Crit Care. 1992; 1: 54-64PubMed Google Scholar In this case of SVC syndrome caused by advanced pulmonary artery leiomyosarcoma, combined therapy with radiation and high-dose chemotherapy led to a significant reduction in tumor bulk. The previously unresectable tumor was then removed with a standard pneumonectomy and the patient has had a good functional outcome." @default.
• W2009348501 created "2016-06-24" @default.
• W2009348501 creator A5000251366 @default.
• W2009348501 creator A5003985388 @default.
• W2009348501 creator A5005777048 @default.
• W2009348501 creator A5032149320 @default.
• W2009348501 creator A5068146106 @default.
• W2009348501 creator A5087341055 @default.
• W2009348501 date "1999-10-01" @default.
• W2009348501 modified "2023-09-30" @default.
• W2009348501 title "Superior vena cava syndrome caused by pulmonary artery sarcoma" @default.
• W2009348501 cites W2026022248 @default.
• W2009348501 cites W2095373596 @default.
• W2009348501 cites W2145192050 @default.
• W2009348501 cites W2289340589 @default.
• W2009348501 doi "https://doi.org/10.1016/s0022-5223(99)70024-3" @default.
• W2009348501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10504645" @default.
• W2009348501 hasPublicationYear "1999" @default.
• W2009348501 type Work @default.
• W2009348501 sameAs 2009348501 @default.
• W2009348501 citedByCount "5" @default.
• W2009348501 countsByYear W20093485012012 @default.
• W2009348501 countsByYear W20093485012020 @default.
• W2009348501 crossrefType "journal-article" @default.
• W2009348501 hasAuthorship W2009348501A5000251366 @default.
• W2009348501 hasAuthorship W2009348501A5003985388 @default.
• W2009348501 hasAuthorship W2009348501A5005777048 @default.
• W2009348501 hasAuthorship W2009348501A5032149320 @default.
• W2009348501 hasAuthorship W2009348501A5068146106 @default.
• W2009348501 hasAuthorship W2009348501A5087341055 @default.
• W2009348501 hasBestOaLocation W20093485011 @default.
• W2009348501 hasConcept C126322002 @default.
• W2009348501 hasConcept C126838900 @default.
• W2009348501 hasConcept C142724271 @default.
• W2009348501 hasConcept C164705383 @default.
• W2009348501 hasConcept C2777953354 @default.
• W2009348501 hasConcept C2778256501 @default.
• W2009348501 hasConcept C2780940725 @default.
• W2009348501 hasConcept C2908767450 @default.
• W2009348501 hasConcept C2993032758 @default.
• W2009348501 hasConcept C71924100 @default.
• W2009348501 hasConceptScore W2009348501C126322002 @default.
• W2009348501 hasConceptScore W2009348501C126838900 @default.
• W2009348501 hasConceptScore W2009348501C142724271 @default.
• W2009348501 hasConceptScore W2009348501C164705383 @default.
• W2009348501 hasConceptScore W2009348501C2777953354 @default.
• W2009348501 hasConceptScore W2009348501C2778256501 @default.
• W2009348501 hasConceptScore W2009348501C2780940725 @default.
• W2009348501 hasConceptScore W2009348501C2908767450 @default.
• W2009348501 hasConceptScore W2009348501C2993032758 @default.
• W2009348501 hasConceptScore W2009348501C71924100 @default.
• W2009348501 hasIssue "4" @default.
• W2009348501 hasLocation W20093485011 @default.
• W2009348501 hasLocation W20093485012 @default.
• W2009348501 hasOpenAccess W2009348501 @default.
• W2009348501 hasPrimaryLocation W20093485011 @default.
• W2009348501 hasRelatedWork W2004481728 @default.
• W2009348501 hasRelatedWork W2009348501 @default.
• W2009348501 hasRelatedWork W2064255782 @default.
• W2009348501 hasRelatedWork W2406235717 @default.
• W2009348501 hasRelatedWork W2414525166 @default.
• W2009348501 hasRelatedWork W2692373806 @default.
• W2009348501 hasRelatedWork W2960930985 @default.
• W2009348501 hasRelatedWork W3027403189 @default.
• W2009348501 hasRelatedWork W4240737564 @default.
• W2009348501 hasRelatedWork W4248178612 @default.
• W2009348501 hasVolume "118" @default.
• W2009348501 isParatext "false" @default.
• W2009348501 isRetracted "false" @default.
• W2009348501 magId "2009348501" @default.
• W2009348501 workType "article" @default.