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- W2009356188 abstract "The evolution of motor nerve degeneration was examined in gracile axonal dystrophy (GAD) mutant mice, which develop initial sensory ataxia and subsequent motor paresis. Using the anterior gracilis (AG) muscle, which is innervated at two discrete and well-separated end-plate zones, we demonstrated that axonal degeneration occurred first at motor nerve terminals in the distal end-plate zone, and then extended gradually from the distal to the more proximal parts of affected axons in the intramuscular nerve trunk. In contrast to the degeneration in the distal zone, active degeneration was less marked in the proximal endplate zone and, furthermore, most terminal axons had begun to produce regenerating sprouts. Ventral horn cells were histologically normal, even at advanced stages. These results indicate that, as previously observed in sensory nerves, dying back degeneration progresses later in the lower motor neuron system, even within one muscle. The mechanism(s) influencing the activation of axonal regeneration are discussed. This mutant mouse will be a useful model for the study of regenerating phenomena in dying back degeneration of genetically compromised motor neurons, as well as for the study of the pathogenesis of hereditary sensory and motor neuropathies in man." @default.
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- W2009356188 title "Progressive degeneration of motor nerve terminals in GAD mutant mouse with hereditary sensory axonopathy" @default.
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- W2009356188 doi "https://doi.org/10.1111/j.1365-2990.1993.tb00403.x" @default.
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