FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009357776> ?p ?o ?g. }

• W2009357776 endingPage "403" @default.
• W2009357776 startingPage "397" @default.
• W2009357776 abstract "Recent decades have seen allergic diseases become endemic in a number of developed countries. Understanding the inflammatory processes that dictate these allergic responses is therefore important.Critical to many allergic responses is the inappropriate release of the type-2 immune-regulatory cytokines: interleukin-4, interleukin-5, interleukin-9, and interleukin-13. The study of these inflammatory mediators has led directly to the development of two new asthma treatments: anti-interleukin-5 and anti-interleukin-13. Until recently, T helper 2 cells were considered to be the major cellular source of type-2 cytokines; however, a paradigm shift occurred with the discovery of a novel population, type-2 innate lymphoid cells (ILC2s), that can produce huge levels of type-2 cytokines and are sufficient to induce allergy in mice. This discovery raises interesting questions about how innate and adaptive type-2 immunity might interact to induce relapsing and remitting episodes of allergy in patients.It is essential that alongside the mechanistic investigation using model organisms, the roles of ILC2s in human disease be explored. Here, we discuss how ILC2 traits, discovered in mouse models, have informed research in humans and how newly identified human ILC2 pathways might provide potential therapeutic benefits in the future." @default.
• W2009357776 created "2016-06-24" @default.
• W2009357776 creator A5013123507 @default.
• W2009357776 creator A5071181398 @default.
• W2009357776 date "2014-10-01" @default.
• W2009357776 modified "2023-10-10" @default.
• W2009357776 title "Type-2 innate lymphoid cells in human allergic disease" @default.
• W2009357776 cites W1512168554 @default.
• W2009357776 cites W1519407136 @default.
• W2009357776 cites W1965632450 @default.
• W2009357776 cites W1973548013 @default.
• W2009357776 cites W1980250352 @default.
• W2009357776 cites W1980690159 @default.
• W2009357776 cites W1981650730 @default.
• W2009357776 cites W1990121282 @default.
• W2009357776 cites W1991225939 @default.
• W2009357776 cites W1994569436 @default.
• W2009357776 cites W1995939269 @default.
• W2009357776 cites W1997745506 @default.
• W2009357776 cites W1998568385 @default.
• W2009357776 cites W1998846885 @default.
• W2009357776 cites W2002740312 @default.
• W2009357776 cites W2007940860 @default.
• W2009357776 cites W2015234837 @default.
• W2009357776 cites W2021701428 @default.
• W2009357776 cites W2023719946 @default.
• W2009357776 cites W2033289727 @default.
• W2009357776 cites W2047882259 @default.
• W2009357776 cites W2050604953 @default.
• W2009357776 cites W2055172715 @default.
• W2009357776 cites W2062783549 @default.
• W2009357776 cites W2068870295 @default.
• W2009357776 cites W2070151667 @default.
• W2009357776 cites W2078498449 @default.
• W2009357776 cites W2083665488 @default.
• W2009357776 cites W2087221993 @default.
• W2009357776 cites W2092520647 @default.
• W2009357776 cites W2094389119 @default.
• W2009357776 cites W2095754126 @default.
• W2009357776 cites W2096545973 @default.
• W2009357776 cites W2097384956 @default.
• W2009357776 cites W2100379729 @default.
• W2009357776 cites W2100705331 @default.
• W2009357776 cites W2100908574 @default.
• W2009357776 cites W2101500685 @default.
• W2009357776 cites W2103572248 @default.
• W2009357776 cites W2106790228 @default.
• W2009357776 cites W2113345965 @default.
• W2009357776 cites W2114962227 @default.
• W2009357776 cites W2121327269 @default.
• W2009357776 cites W2122192920 @default.
• W2009357776 cites W2126612550 @default.
• W2009357776 cites W2127482775 @default.
• W2009357776 cites W2129161823 @default.
• W2009357776 cites W2130509509 @default.
• W2009357776 cites W2132644211 @default.
• W2009357776 cites W2140206763 @default.
• W2009357776 cites W2140686309 @default.
• W2009357776 cites W2142899869 @default.
• W2009357776 cites W2150464681 @default.
• W2009357776 cites W2151325231 @default.
• W2009357776 cites W2152222824 @default.
• W2009357776 cites W2154110743 @default.
• W2009357776 cites W2157710399 @default.
• W2009357776 cites W2158045379 @default.
• W2009357776 cites W2162490282 @default.
• W2009357776 cites W2163870925 @default.
• W2009357776 cites W2165277651 @default.
• W2009357776 cites W2165638693 @default.
• W2009357776 cites W2165933222 @default.
• W2009357776 cites W2315018741 @default.
• W2009357776 cites W4319308391 @default.
• W2009357776 doi "https://doi.org/10.1097/aci.0000000000000090" @default.
• W2009357776 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4154789" @default.
• W2009357776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25115682" @default.
• W2009357776 hasPublicationYear "2014" @default.
• W2009357776 type Work @default.
• W2009357776 sameAs 2009357776 @default.
• W2009357776 citedByCount "85" @default.
• W2009357776 countsByYear W20093577762014 @default.
• W2009357776 countsByYear W20093577762015 @default.
• W2009357776 countsByYear W20093577762016 @default.
• W2009357776 countsByYear W20093577762017 @default.
• W2009357776 countsByYear W20093577762018 @default.
• W2009357776 countsByYear W20093577762019 @default.
• W2009357776 countsByYear W20093577762020 @default.
• W2009357776 countsByYear W20093577762021 @default.
• W2009357776 countsByYear W20093577762022 @default.
• W2009357776 countsByYear W20093577762023 @default.
• W2009357776 crossrefType "journal-article" @default.
• W2009357776 hasAuthorship W2009357776A5013123507 @default.
• W2009357776 hasAuthorship W2009357776A5071181398 @default.
• W2009357776 hasBestOaLocation W20093577761 @default.
• W2009357776 hasConcept C122862929 @default.
• W2009357776 hasConcept C136449434 @default.
• W2009357776 hasConcept C142724271 @default.
• W2009357776 hasConcept C191732599 @default.
• W2009357776 hasConcept C193419808 @default.

• next