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- W2009369591 abstract "p21Cip1/WAF1, known as a cell-cycle inhibitory protein, facilitates neurite outgrowth from neurons when present in the cytoplasm. The molecular mechanism of this action is that p21Cip1/WAF1 forms a complex with Rho-kinase and inhibits its activity. As myelin-derived inhibitors of axonal outgrowth act on neurons by activating Rho, that is responsible for the lack of spontaneous regeneration of the injured central nervous system (CNS), Rho-kinase may be a good molecular target against injuries in the CNS. In this study, we delivered TAT-fusion protein of cytoplasmic p21Cip1/WAF1 locally after dorsal hemisection of the thoracic spinal cord in rats. The treatment significantly stimulated axonal regeneration and recovery of hindlimb function, and inhibited the cavity formation in the spinal cord after the injury. Cytoplasmic p21Cip1/WAF1 may provide a potential therapeutic agent that produces functional regeneration following CNS injuries." @default.
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- W2009369591 date "2004-01-01" @default.
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- W2009369591 title "Cytoplasmic p21Cip1/WAF1 enhances axonal regeneration and functional recovery after spinal cord injury in rats" @default.
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- W2009369591 doi "https://doi.org/10.1016/j.neuroscience.2004.05.010" @default.
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