FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009373989> ?p ?o ?g. }

• W2009373989 abstract "Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DCProstatic adenocarcinoma will affect one in six American men and represents the second leading cause of cancer death in this population. Tumors that are locally invasive/ metastatic at diagnosis cause the majority of prostate cancer deaths. SRC3 is a p160 family coactivator overexpressed in invasive prostate cancers. A recent study in our laboratory demonstrated it is also highly expressed in tumors of the TRAMP mouse, a cancer model in which an androgen-responsive probasin promoter drives expression of the SV40 viral oncogene in several prostate cell types. Global deletion of SRC3 in TRAMP mice arrested primary prostate tumors at the well-differentiated stage and eliminated metastasis.Transformation of prostatic luminal epithelial cells (LECs) into invasive cancers is a key feature of the TRAMP phenotype. Therefore, we hypothesized selective deletion of SRC3 in these cells would inhibit primary tumor growth and metastasis. To test the hypothesis, we crossed floxed SRC3/TRAMP mice with mice harboring a Cre recombinase gene driven by the LEC-specific probasin promoter. Efficacy of SRC3 knockout in SRC3c−/−/TRAMP mice was confirmed via immunohistochemistry and Western blotting.We compared prostate tumor size, composition and metastases in SRC3c−/−/TRAMP vs. WT/TRAMP mice at 12 (n=3/5), 18 (n=7/7), 24 (n=9/9) and 30 (n=6/6) weeks of age. We observed no statistically significant differences in prostate or GU tract weight at any time point, though a trend toward decreased tumor size in the knockout was evident at 30 weeks. Tumor composition differed between SRC3c−/−/TRAMP and WT/TRAMP mice at 24 and 30 weeks. While synaptophysin(+) (neuroendocrine) cells were virtually absent in dedifferentiated regions of WT/TRAMP prostate, large synaptophysin(+) cell clusters were visible in the majority of sections taken from prostates of in SRC3c−/−/TRAMP mice. Neuroendocrine cell clusters were positive for SRC3 and negative for AR. Interestingly, 24 and 30 week-old SRC3c−/−/TRAMP mice also had tumors of the liver, lung and kidney: common sites of neuroendocrine metastasis in the TRAMP model.Given that SRC3c−/−/TRAMP mice have primary tumors of equivalent size to WT/TRAMP but skewed toward neuroendocrine composition, SRC3 deletion in luminal epithelial cells appears to inhibit cancer growth in a cell autonomous fashion thus enabling neuroendocrine proliferation and metastasis. Since global SRC3−/−/TRAMP mice have no neuroendocrine tumors, our findings indicate SRC3 may also act as an oncogene in neuroendocrine cancer.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3245." @default.
• W2009373989 created "2016-06-24" @default.
• W2009373989 creator A5009432822 @default.
• W2009373989 creator A5026743154 @default.
• W2009373989 creator A5041163845 @default.
• W2009373989 creator A5058638821 @default.
• W2009373989 creator A5075130252 @default.
• W2009373989 date "2010-04-15" @default.
• W2009373989 modified "2023-09-26" @default.
• W2009373989 title "Abstract 3245: SRC-3: A prostate cancer oncogene with the same modus operandi in different niches" @default.
• W2009373989 doi "https://doi.org/10.1158/1538-7445.am10-3245" @default.
• W2009373989 hasPublicationYear "2010" @default.
• W2009373989 type Work @default.
• W2009373989 sameAs 2009373989 @default.
• W2009373989 citedByCount "0" @default.
• W2009373989 crossrefType "proceedings-article" @default.
• W2009373989 hasAuthorship W2009373989A5009432822 @default.
• W2009373989 hasAuthorship W2009373989A5026743154 @default.
• W2009373989 hasAuthorship W2009373989A5041163845 @default.
• W2009373989 hasAuthorship W2009373989A5058638821 @default.
• W2009373989 hasAuthorship W2009373989A5075130252 @default.
• W2009373989 hasConcept C121608353 @default.
• W2009373989 hasConcept C126322002 @default.
• W2009373989 hasConcept C142724271 @default.
• W2009373989 hasConcept C2776235491 @default.
• W2009373989 hasConcept C2779013556 @default.
• W2009373989 hasConcept C2780192828 @default.
• W2009373989 hasConcept C2780940892 @default.
• W2009373989 hasConcept C2781018059 @default.
• W2009373989 hasConcept C29537977 @default.
• W2009373989 hasConcept C502942594 @default.
• W2009373989 hasConcept C71924100 @default.
• W2009373989 hasConceptScore W2009373989C121608353 @default.
• W2009373989 hasConceptScore W2009373989C126322002 @default.
• W2009373989 hasConceptScore W2009373989C142724271 @default.
• W2009373989 hasConceptScore W2009373989C2776235491 @default.
• W2009373989 hasConceptScore W2009373989C2779013556 @default.
• W2009373989 hasConceptScore W2009373989C2780192828 @default.
• W2009373989 hasConceptScore W2009373989C2780940892 @default.
• W2009373989 hasConceptScore W2009373989C2781018059 @default.
• W2009373989 hasConceptScore W2009373989C29537977 @default.
• W2009373989 hasConceptScore W2009373989C502942594 @default.
• W2009373989 hasConceptScore W2009373989C71924100 @default.
• W2009373989 hasLocation W20093739891 @default.
• W2009373989 hasOpenAccess W2009373989 @default.
• W2009373989 hasPrimaryLocation W20093739891 @default.
• W2009373989 hasRelatedWork W1879688034 @default.
• W2009373989 hasRelatedWork W1964174519 @default.
• W2009373989 hasRelatedWork W1965743832 @default.
• W2009373989 hasRelatedWork W1973455999 @default.
• W2009373989 hasRelatedWork W2005903270 @default.
• W2009373989 hasRelatedWork W2013068686 @default.
• W2009373989 hasRelatedWork W2018301474 @default.
• W2009373989 hasRelatedWork W2022799448 @default.
• W2009373989 hasRelatedWork W2065608086 @default.
• W2009373989 hasRelatedWork W2071084003 @default.
• W2009373989 hasRelatedWork W2077788783 @default.
• W2009373989 hasRelatedWork W2087775262 @default.
• W2009373989 hasRelatedWork W2118432877 @default.
• W2009373989 hasRelatedWork W2120467578 @default.
• W2009373989 hasRelatedWork W2140607688 @default.
• W2009373989 hasRelatedWork W2300801278 @default.
• W2009373989 hasRelatedWork W2415251168 @default.
• W2009373989 hasRelatedWork W2742616261 @default.
• W2009373989 hasRelatedWork W2896584497 @default.
• W2009373989 hasRelatedWork W3125347264 @default.
• W2009373989 isParatext "false" @default.
• W2009373989 isRetracted "false" @default.
• W2009373989 magId "2009373989" @default.
• W2009373989 workType "article" @default.