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• W2009374460 abstract "Werner syndrome (WS) is a human genetic disorder characterized by extensive clinical features of premature aging. Ataxia-telengiectasia (A-T) is a multisystem human genomic instability syndrome that includes premature aging in some of the patients. WRN and ATM, the proteins defective in WS and A-T, respectively, play significant roles in the maintenance of genomic stability and are involved in several DNA metabolic pathways. A role for WRN in DNA repair has been proposed; however, this study provides evidence that WRN is also involved in ATM pathway activation and in a S-phase checkpoint in cells exposed to DNA interstrand cross-link-induced double-strand breaks. Depletion of WRN in such cells by RNA interference results in an intra-S checkpoint defect, and interferes with activation of ATM as well as downstream phosphorylation of ATM target proteins. Treatment of cells under replication stress with the ATM kinase inhibitor KU 55933 results in a S-phase checkpoint defect similar to that observed in WRN shRNA cells. Moreover, gamma H2AX levels are higher in WRN shRNA cells than in control cells 6 and 16 h after exposure to psoralen DNA cross-links. These results suggest that WRN and ATM participate in a replication checkpoint response, in which WRN facilitates ATM activation in cells with psoralen DNA cross-link-induced collapsed replication forks." @default.
• W2009374460 created "2016-06-24" @default.
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• W2009374460 creator A5089917586 @default.
• W2009374460 date "2008-09-01" @default.
• W2009374460 modified "2023-09-23" @default.
• W2009374460 title "WRN Is Required for ATM Activation and the S-Phase Checkpoint in Response to Interstrand Cross-Link–Induced DNA Double-Strand Breaks" @default.
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• W2009374460 cites W1538603370 @default.
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• W2009374460 cites W1973268287 @default.
• W2009374460 cites W1977518145 @default.
• W2009374460 cites W1978331091 @default.
• W2009374460 cites W1978530463 @default.
• W2009374460 cites W1978727038 @default.
• W2009374460 cites W1988524165 @default.
• W2009374460 cites W1993913655 @default.
• W2009374460 cites W1994657894 @default.
• W2009374460 cites W1997928877 @default.
• W2009374460 cites W1998617902 @default.
• W2009374460 cites W2000206408 @default.
• W2009374460 cites W2003745942 @default.
• W2009374460 cites W2003992275 @default.
• W2009374460 cites W2009007206 @default.
• W2009374460 cites W2018458310 @default.
• W2009374460 cites W2020151423 @default.
• W2009374460 cites W2022811243 @default.
• W2009374460 cites W2031203839 @default.
• W2009374460 cites W2032145455 @default.
• W2009374460 cites W2035174191 @default.
• W2009374460 cites W2038451572 @default.
• W2009374460 cites W2041156660 @default.
• W2009374460 cites W2043544652 @default.
• W2009374460 cites W2045526190 @default.
• W2009374460 cites W2046723353 @default.
• W2009374460 cites W2049921243 @default.
• W2009374460 cites W2054258563 @default.
• W2009374460 cites W2055237449 @default.
• W2009374460 cites W2059078585 @default.
• W2009374460 cites W2059501883 @default.
• W2009374460 cites W2060717672 @default.
• W2009374460 cites W2062284662 @default.
• W2009374460 cites W2064310741 @default.
• W2009374460 cites W2067022597 @default.
• W2009374460 cites W2076926674 @default.
• W2009374460 cites W2077260273 @default.
• W2009374460 cites W2077709632 @default.
• W2009374460 cites W2082234447 @default.
• W2009374460 cites W2084089807 @default.
• W2009374460 cites W2084712319 @default.
• W2009374460 cites W2088848743 @default.
• W2009374460 cites W2090861867 @default.
• W2009374460 cites W2094556673 @default.
• W2009374460 cites W2098585738 @default.
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• W2009374460 cites W2129753373 @default.
• W2009374460 cites W2134365342 @default.
• W2009374460 cites W2136367213 @default.
• W2009374460 cites W2137936832 @default.
• W2009374460 cites W2138466316 @default.
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• W2009374460 doi "https://doi.org/10.1091/mbc.e07-07-0698" @default.
• W2009374460 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2526706" @default.
• W2009374460 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18596239" @default.
• W2009374460 hasPublicationYear "2008" @default.
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