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- W2009376475 abstract "This editorial refers to ‘RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility’ by K.L. Poon et al., doi:10.1093/cvr/cvs095. RNA-binding proteins affect the proteome of a single cell by controlling alternative splicing, transport, localization, and stability of their target RNAs.1 They often display tissue-specific expression, and their crucial influence on the protein set-up especially in muscle cells has become recognized recently.2 A contribution by Poon et al. 3 focuses on RBM24 (also known as Seb-4) and its role in heart development. Their interest was sparked by the observation that Rbm24 is dramatically up-regulated in human embryonic stem cells upon differentiation into cardiomyocytes. They went on to characterize its expression pattern in zebrafish embryos, where its expression was mainly observed in the heart and somites. This fits well with previous data from another group on Xenopus embryos, who had shown a region-specific expression pattern of Rbm24 in the heart and the somites with minor levels in the lens and otic vesicles.4 A major part of the zebrafish genome is duplicated,5 and RMB24 also exists as two variants, Rbm24a and Rbm24b. Poon et al. focused their work on Rbm24a and were able to show that knockdown of its expression by morpholino oligonucleotides in zebrafish leads to impaired contractility of the heart.3 The supplementary data show no discernible effects on the somites, and the vasculature also seems to be normal in the morphants. The heart phenotype is explained by a reduced complexity of the myofibrillar meshwork in the embryonic cardiomyocytes, potentially due to a slight …" @default.
- W2009376475 created "2016-06-24" @default.
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- W2009376475 date "2012-04-16" @default.
- W2009376475 modified "2023-09-23" @default.
- W2009376475 title "RBM24: a 'Regional Business Manager' in charge of the maintenance of sarcomeric protein expression 24 h a day?" @default.
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- W2009376475 doi "https://doi.org/10.1093/cvr/cvs151" @default.
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