Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009379464> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2009379464 endingPage "1131" @default.
- W2009379464 startingPage "1127" @default.
- W2009379464 abstract "The aim of the present study was to examine the role of the mitochondrial (mt) DNA common deletion (CD) 4977 (mtDNACD4977) in the hair shaft in patients with presbycusis. A total of 87 individuals with presbycusis and 95 normal‑hearing controls were selected based on strict audiometric criteria. Nested polymerase chain reaction (PCR), sequencing and quantitative (q)PCR were used to examine the expression levels of mtDNACD4977 in the hair shaft in presbycusis. Nested PCR of the hair shaft demonstrated that 8/95 cases with normal hearing were found to be positive for mtDNACD4977, as compared with 59/87 cases in the presbycusis group. The mtDNACD4977 was positive in 22/43 cases with mild‑to‑moderate hearing loss, 25/31 cases with moderate‑to‑severe, severe hearing loss, and 12/13 cases with profound deafness. Statistically significant differences in mtDNACD4977 expression were identified among all of the groups (P<0.001). The sequencing and qPCR assays demonstrated a trend towards an increase in the mean CD level of mtDNACD4977 with a more severe hearing loss at 8 kHz (r=0.778, P<0.001) and all ranges of frequency (r=0.858, P<0.001). In conclusion, the present study demonstrates a correlation between mtDNACD4977 in the human hair shaft and the severity of hearing loss in presbycusis." @default.
- W2009379464 created "2016-06-24" @default.
- W2009379464 creator A5006901857 @default.
- W2009379464 creator A5007312763 @default.
- W2009379464 creator A5044381789 @default.
- W2009379464 creator A5057287134 @default.
- W2009379464 date "2014-11-06" @default.
- W2009379464 modified "2023-09-29" @default.
- W2009379464 title "Association between the mitochondrial DNA 4977 common deletion in the hair shaft and hearing loss in presbycusis" @default.
- W2009379464 cites W146344741 @default.
- W2009379464 cites W1971215275 @default.
- W2009379464 cites W1997859847 @default.
- W2009379464 cites W2019596298 @default.
- W2009379464 cites W2029384341 @default.
- W2009379464 cites W2046287285 @default.
- W2009379464 cites W2054211712 @default.
- W2009379464 cites W2055007382 @default.
- W2009379464 cites W2059171059 @default.
- W2009379464 cites W2059494962 @default.
- W2009379464 cites W2064919953 @default.
- W2009379464 cites W2072059255 @default.
- W2009379464 cites W2077693712 @default.
- W2009379464 cites W2081179384 @default.
- W2009379464 cites W2081398949 @default.
- W2009379464 cites W2084250858 @default.
- W2009379464 cites W2089939834 @default.
- W2009379464 cites W2098905275 @default.
- W2009379464 cites W2107488742 @default.
- W2009379464 cites W2115174625 @default.
- W2009379464 cites W2130753450 @default.
- W2009379464 cites W2134829363 @default.
- W2009379464 cites W2157133565 @default.
- W2009379464 cites W2160693062 @default.
- W2009379464 doi "https://doi.org/10.3892/mmr.2014.2877" @default.
- W2009379464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25373716" @default.
- W2009379464 hasPublicationYear "2014" @default.
- W2009379464 type Work @default.
- W2009379464 sameAs 2009379464 @default.
- W2009379464 citedByCount "4" @default.
- W2009379464 countsByYear W20093794642017 @default.
- W2009379464 countsByYear W20093794642018 @default.
- W2009379464 countsByYear W20093794642019 @default.
- W2009379464 countsByYear W20093794642022 @default.
- W2009379464 crossrefType "journal-article" @default.
- W2009379464 hasAuthorship W2009379464A5006901857 @default.
- W2009379464 hasAuthorship W2009379464A5007312763 @default.
- W2009379464 hasAuthorship W2009379464A5044381789 @default.
- W2009379464 hasAuthorship W2009379464A5057287134 @default.
- W2009379464 hasBestOaLocation W20093794641 @default.
- W2009379464 hasConcept C104317684 @default.
- W2009379464 hasConcept C24586158 @default.
- W2009379464 hasConcept C2779912225 @default.
- W2009379464 hasConcept C2780493683 @default.
- W2009379464 hasConcept C48023723 @default.
- W2009379464 hasConcept C49105822 @default.
- W2009379464 hasConcept C54355233 @default.
- W2009379464 hasConcept C548259974 @default.
- W2009379464 hasConcept C71924100 @default.
- W2009379464 hasConcept C86803240 @default.
- W2009379464 hasConceptScore W2009379464C104317684 @default.
- W2009379464 hasConceptScore W2009379464C24586158 @default.
- W2009379464 hasConceptScore W2009379464C2779912225 @default.
- W2009379464 hasConceptScore W2009379464C2780493683 @default.
- W2009379464 hasConceptScore W2009379464C48023723 @default.
- W2009379464 hasConceptScore W2009379464C49105822 @default.
- W2009379464 hasConceptScore W2009379464C54355233 @default.
- W2009379464 hasConceptScore W2009379464C548259974 @default.
- W2009379464 hasConceptScore W2009379464C71924100 @default.
- W2009379464 hasConceptScore W2009379464C86803240 @default.
- W2009379464 hasIssue "2" @default.
- W2009379464 hasLocation W20093794641 @default.
- W2009379464 hasLocation W20093794642 @default.
- W2009379464 hasOpenAccess W2009379464 @default.
- W2009379464 hasPrimaryLocation W20093794641 @default.
- W2009379464 hasRelatedWork W1968431082 @default.
- W2009379464 hasRelatedWork W2021216982 @default.
- W2009379464 hasRelatedWork W2061383513 @default.
- W2009379464 hasRelatedWork W2337989314 @default.
- W2009379464 hasRelatedWork W2407314305 @default.
- W2009379464 hasRelatedWork W2426715968 @default.
- W2009379464 hasRelatedWork W2439970882 @default.
- W2009379464 hasRelatedWork W3112336845 @default.
- W2009379464 hasRelatedWork W4281297633 @default.
- W2009379464 hasRelatedWork W4361018364 @default.
- W2009379464 hasVolume "11" @default.
- W2009379464 isParatext "false" @default.
- W2009379464 isRetracted "false" @default.
- W2009379464 magId "2009379464" @default.
- W2009379464 workType "article" @default.