FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009379675> ?p ?o ?g. }

• W2009379675 endingPage "613" @default.
• W2009379675 startingPage "609" @default.
• W2009379675 abstract "AP-1 transcriptional activity is stimulated by the transformation promoters phorbol 12-myristate 13-acetate (12-O-tetradecanoylphorbol 13-acetate, TPA) and epidermal growth factor (EGF) in promotion-sensitive (P+) but not in promotion-resistant (P-) JB6 mouse epidermal cell lines. Although TPA stimulates expression of the jun and fos family genes, only c-jun expression shows higher elevation in P+ cells than in P- cells. The present study tests the hypothesis that induced AP-1 activity is required for tumor promoter-induced transformation in JB6 P+ cells. Both retinoic acid and the glucocorticoid fluocinolone acetonide inhibited basal and TPA-induced AP-1 activities that were tested with a stromelysin promoter-chloramphenicol acetyltransferase reporter gene in P+ cells. Since both retinoic acid and fluocinolone acetonide are active in inhibiting TPA-induced anchorage-independent transformation of P+ cells in the dose range that blocks TPA-induced AP-1 activity, their antipromoting effects may occur through inhibition of AP-1 activity. To test the hypothesis with a more specific inhibitor, stable clonal transfectants of P+ cells expressing dominant negative c-jun mutant encoding a transcriptionally inactive product were analyzed. All transfectants showed a block in TPA and EGF induction of AP-1 activity. All transfectants also showed inhibition of TPA-induced transformation, and most transfectants showed a block in EGF-induced transformation. These results indicate that AP-1 activity is required for TPA- or EGF-induced transformation. This work demonstrates that a specific block in induced AP-1 activity inhibits tumor promoter-induced transformation." @default.
• W2009379675 created "2016-06-24" @default.
• W2009379675 creator A5047121561 @default.
• W2009379675 creator A5048962207 @default.
• W2009379675 creator A5074636897 @default.
• W2009379675 creator A5080017108 @default.
• W2009379675 creator A5081561534 @default.
• W2009379675 date "1994-01-18" @default.
• W2009379675 modified "2023-10-18" @default.
• W2009379675 title "Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells." @default.
• W2009379675 cites W126627744 @default.
• W2009379675 cites W1530265254 @default.
• W2009379675 cites W155521797 @default.
• W2009379675 cites W1916260177 @default.
• W2009379675 cites W1944595096 @default.
• W2009379675 cites W1959523209 @default.
• W2009379675 cites W1963530157 @default.
• W2009379675 cites W1964303657 @default.
• W2009379675 cites W1971624992 @default.
• W2009379675 cites W1980722886 @default.
• W2009379675 cites W1983578591 @default.
• W2009379675 cites W1987453246 @default.
• W2009379675 cites W1987557547 @default.
• W2009379675 cites W1998903985 @default.
• W2009379675 cites W2046983903 @default.
• W2009379675 cites W2052977964 @default.
• W2009379675 cites W2063318366 @default.
• W2009379675 cites W2068665571 @default.
• W2009379675 cites W2072783120 @default.
• W2009379675 cites W2075210500 @default.
• W2009379675 cites W2080493796 @default.
• W2009379675 cites W2081177620 @default.
• W2009379675 cites W2081612928 @default.
• W2009379675 cites W2097483036 @default.
• W2009379675 cites W2103468507 @default.
• W2009379675 cites W2113992548 @default.
• W2009379675 cites W2240627417 @default.
• W2009379675 cites W2416585022 @default.
• W2009379675 cites W97050006 @default.
• W2009379675 cites W1779787158 @default.
• W2009379675 doi "https://doi.org/10.1073/pnas.91.2.609" @default.
• W2009379675 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/42998" @default.
• W2009379675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8290571" @default.
• W2009379675 hasPublicationYear "1994" @default.
• W2009379675 type Work @default.
• W2009379675 sameAs 2009379675 @default.
• W2009379675 citedByCount "361" @default.
• W2009379675 countsByYear W20093796752012 @default.
• W2009379675 countsByYear W20093796752013 @default.
• W2009379675 countsByYear W20093796752014 @default.
• W2009379675 countsByYear W20093796752015 @default.
• W2009379675 countsByYear W20093796752016 @default.
• W2009379675 countsByYear W20093796752017 @default.
• W2009379675 countsByYear W20093796752018 @default.
• W2009379675 countsByYear W20093796752019 @default.
• W2009379675 countsByYear W20093796752020 @default.
• W2009379675 countsByYear W20093796752021 @default.
• W2009379675 countsByYear W20093796752022 @default.
• W2009379675 countsByYear W20093796752023 @default.
• W2009379675 crossrefType "journal-article" @default.
• W2009379675 hasAuthorship W2009379675A5047121561 @default.
• W2009379675 hasAuthorship W2009379675A5048962207 @default.
• W2009379675 hasAuthorship W2009379675A5074636897 @default.
• W2009379675 hasAuthorship W2009379675A5080017108 @default.
• W2009379675 hasAuthorship W2009379675A5081561534 @default.
• W2009379675 hasBestOaLocation W20093796752 @default.
• W2009379675 hasConcept C104317684 @default.
• W2009379675 hasConcept C1292079 @default.
• W2009379675 hasConcept C150194340 @default.
• W2009379675 hasConcept C153911025 @default.
• W2009379675 hasConcept C161733203 @default.
• W2009379675 hasConcept C185592680 @default.
• W2009379675 hasConcept C195794163 @default.
• W2009379675 hasConcept C2776362946 @default.
• W2009379675 hasConcept C2777168633 @default.
• W2009379675 hasConcept C2780043322 @default.
• W2009379675 hasConcept C2780122803 @default.
• W2009379675 hasConcept C2780730277 @default.
• W2009379675 hasConcept C2781121885 @default.
• W2009379675 hasConcept C2909761558 @default.
• W2009379675 hasConcept C3017695315 @default.
• W2009379675 hasConcept C54355233 @default.
• W2009379675 hasConcept C55493867 @default.
• W2009379675 hasConcept C555283112 @default.
• W2009379675 hasConcept C62478195 @default.
• W2009379675 hasConcept C81885089 @default.
• W2009379675 hasConcept C86803240 @default.
• W2009379675 hasConcept C95444343 @default.
• W2009379675 hasConceptScore W2009379675C104317684 @default.
• W2009379675 hasConceptScore W2009379675C1292079 @default.
• W2009379675 hasConceptScore W2009379675C150194340 @default.
• W2009379675 hasConceptScore W2009379675C153911025 @default.
• W2009379675 hasConceptScore W2009379675C161733203 @default.
• W2009379675 hasConceptScore W2009379675C185592680 @default.
• W2009379675 hasConceptScore W2009379675C195794163 @default.
• W2009379675 hasConceptScore W2009379675C2776362946 @default.
• W2009379675 hasConceptScore W2009379675C2777168633 @default.
• W2009379675 hasConceptScore W2009379675C2780043322 @default.

• next