Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009381500> ?p ?o ?g. }
- W2009381500 endingPage "7064" @default.
- W2009381500 startingPage "7060" @default.
- W2009381500 abstract "Glutaredoxins (GRXs), also known as thioltransferases, use glutathione as a cofactor for reduction of disulfides in prokaryotes and eukaryotes. We demonstrate that the vaccinia virus O2L open reading frame encodes a functional GRX, as predicted by Johnson et al. [Johnson, G. P., Goebel, S. J., Perkus, M. E., Davis, S. W., Winslow, J. P. & Paoletti, E. (1991) Virology 181, 378-381] from sequence homology. The 12-kDa protein product of the O2L open reading frame was synthesized after viral DNA replication, coincident with a major increase in cytoplasmic glutathione-dependent thioltransferase activity. The protein was associated with purified vaccinia virions and was not released by treatment with a nonionic detergent unless dithiothreitol was added. The virion-derived protein, as well as a recombinant form expressed in Escherichia coli, exhibited thioltransferase and dehydroascorbate reductase activities indicative of a functional GRX. The postreplicative synthesis of vaccinia virus GRX and its association with virions suggest that the enzyme may have novel roles in the virus growth cycle." @default.
- W2009381500 created "2016-06-24" @default.
- W2009381500 creator A5035265346 @default.
- W2009381500 creator A5082770120 @default.
- W2009381500 date "1992-08-01" @default.
- W2009381500 modified "2023-09-26" @default.
- W2009381500 title "Glutaredoxin homolog encoded by vaccinia virus is a virion-associated enzyme with thioltransferase and dehydroascorbate reductase activities." @default.
- W2009381500 cites W1487001072 @default.
- W2009381500 cites W1493342615 @default.
- W2009381500 cites W1503977217 @default.
- W2009381500 cites W1507082667 @default.
- W2009381500 cites W1511304527 @default.
- W2009381500 cites W1512789383 @default.
- W2009381500 cites W1521493375 @default.
- W2009381500 cites W1538093459 @default.
- W2009381500 cites W1546917481 @default.
- W2009381500 cites W1551150032 @default.
- W2009381500 cites W1554041356 @default.
- W2009381500 cites W1555938743 @default.
- W2009381500 cites W1558516521 @default.
- W2009381500 cites W1564327094 @default.
- W2009381500 cites W1576348820 @default.
- W2009381500 cites W1578163958 @default.
- W2009381500 cites W1582362950 @default.
- W2009381500 cites W1584851347 @default.
- W2009381500 cites W1671377935 @default.
- W2009381500 cites W1833536387 @default.
- W2009381500 cites W1895187084 @default.
- W2009381500 cites W1920619128 @default.
- W2009381500 cites W1973475159 @default.
- W2009381500 cites W1975085160 @default.
- W2009381500 cites W1975370965 @default.
- W2009381500 cites W1986911979 @default.
- W2009381500 cites W2018289835 @default.
- W2009381500 cites W201838965 @default.
- W2009381500 cites W2038166412 @default.
- W2009381500 cites W2042237864 @default.
- W2009381500 cites W2062357195 @default.
- W2009381500 cites W2062579188 @default.
- W2009381500 cites W2069326406 @default.
- W2009381500 cites W2073552053 @default.
- W2009381500 cites W2074467292 @default.
- W2009381500 cites W2087090258 @default.
- W2009381500 cites W2090719106 @default.
- W2009381500 cites W2100837269 @default.
- W2009381500 cites W2151545080 @default.
- W2009381500 cites W4247896860 @default.
- W2009381500 doi "https://doi.org/10.1073/pnas.89.15.7060" @default.
- W2009381500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/49645" @default.
- W2009381500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1496000" @default.
- W2009381500 hasPublicationYear "1992" @default.
- W2009381500 type Work @default.
- W2009381500 sameAs 2009381500 @default.
- W2009381500 citedByCount "63" @default.
- W2009381500 countsByYear W20093815002013 @default.
- W2009381500 countsByYear W20093815002014 @default.
- W2009381500 countsByYear W20093815002015 @default.
- W2009381500 countsByYear W20093815002017 @default.
- W2009381500 countsByYear W20093815002020 @default.
- W2009381500 countsByYear W20093815002022 @default.
- W2009381500 countsByYear W20093815002023 @default.
- W2009381500 crossrefType "journal-article" @default.
- W2009381500 hasAuthorship W2009381500A5035265346 @default.
- W2009381500 hasAuthorship W2009381500A5082770120 @default.
- W2009381500 hasBestOaLocation W20093815001 @default.
- W2009381500 hasConcept C104317684 @default.
- W2009381500 hasConcept C125619963 @default.
- W2009381500 hasConcept C153911025 @default.
- W2009381500 hasConcept C159047783 @default.
- W2009381500 hasConcept C167625842 @default.
- W2009381500 hasConcept C181199279 @default.
- W2009381500 hasConcept C185592680 @default.
- W2009381500 hasConcept C2522874641 @default.
- W2009381500 hasConcept C2781356689 @default.
- W2009381500 hasConcept C40767141 @default.
- W2009381500 hasConcept C47289529 @default.
- W2009381500 hasConcept C538909803 @default.
- W2009381500 hasConcept C55493867 @default.
- W2009381500 hasConcept C86803240 @default.
- W2009381500 hasConceptScore W2009381500C104317684 @default.
- W2009381500 hasConceptScore W2009381500C125619963 @default.
- W2009381500 hasConceptScore W2009381500C153911025 @default.
- W2009381500 hasConceptScore W2009381500C159047783 @default.
- W2009381500 hasConceptScore W2009381500C167625842 @default.
- W2009381500 hasConceptScore W2009381500C181199279 @default.
- W2009381500 hasConceptScore W2009381500C185592680 @default.
- W2009381500 hasConceptScore W2009381500C2522874641 @default.
- W2009381500 hasConceptScore W2009381500C2781356689 @default.
- W2009381500 hasConceptScore W2009381500C40767141 @default.
- W2009381500 hasConceptScore W2009381500C47289529 @default.
- W2009381500 hasConceptScore W2009381500C538909803 @default.
- W2009381500 hasConceptScore W2009381500C55493867 @default.
- W2009381500 hasConceptScore W2009381500C86803240 @default.
- W2009381500 hasIssue "15" @default.
- W2009381500 hasLocation W20093815001 @default.
- W2009381500 hasLocation W20093815002 @default.
- W2009381500 hasLocation W20093815003 @default.
- W2009381500 hasLocation W20093815004 @default.