FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009386574> ?p ?o ?g. }

• W2009386574 endingPage "294" @default.
• W2009386574 startingPage "269" @default.
• W2009386574 abstract "In mice and in young adult humans, the subventricular zone (SVZ) contains multipotent, dividing astrocytes, some of which, when cultured, produce neurospheres that differentiate into neurons and glia. It is unknown whether the SVZ of very old humans has this capacity. Here, we report that neural stem/progenitor cells can also be cultured from rapid autopsy samples of SVZ from elderly human subjects, including patients with age-related neurologic disorders. Histological sections of SVZ from these cases showed a glial fibrillary acidic protein (GFAP)-positive ribbon of astrocytes similar to the astrocyte ribbon in human periventricular white matter biopsies that is reported to be a rich source of neural progenitors. Cultures of the SVZ contained 1) neurospheres with a core of Musashi-1-, nestin-, and nucleostemin-immunopositive cells as well as more differentiated GFAP-positive astrocytes; 2) SMI-311-, MAP2a/b-, and beta-tubulin(III)-positive neurons; and 3) galactocerebroside-positive oligodendrocytes. Neurospheres continued to generate differentiated progeny for months after primary culturing, in some cases nearly 2 years postinitial plating. Patch clamp studies of differentiated SVZ cells expressing neuron-specific antigens revealed voltage-dependent, tetrodotoxin-sensitive, inward Na+ currents and voltage-dependent, delayed, slowly inactivating K+ currents, electrophysiologic characteristics of neurons. A subpopulation of these cells also exhibited responses consistent with the kinetics and pharmacology of the h-current. However, although these cells displayed some aspects of neuronal function, they remained immature, insofar as they did not fire action potentials. These studies suggest that human neural progenitor activity may remain viable throughout much of the life span, even in the face of severe neurodegenerative disease." @default.
• W2009386574 created "2016-06-24" @default.
• W2009386574 creator A5002563511 @default.
• W2009386574 creator A5013180706 @default.
• W2009386574 creator A5023704622 @default.
• W2009386574 creator A5029702060 @default.
• W2009386574 creator A5032600833 @default.
• W2009386574 creator A5044558166 @default.
• W2009386574 creator A5057055806 @default.
• W2009386574 creator A5059221638 @default.
• W2009386574 creator A5069982928 @default.
• W2009386574 creator A5071704528 @default.
• W2009386574 creator A5090528258 @default.
• W2009386574 date "2009-03-18" @default.
• W2009386574 modified "2023-10-02" @default.
• W2009386574 title "Subventricular zone neural progenitors from rapid brain autopsies of elderly subjects with and without neurodegenerative disease" @default.
• W2009386574 cites W1469270584 @default.
• W2009386574 cites W1487222554 @default.
• W2009386574 cites W1487852103 @default.
• W2009386574 cites W1503270785 @default.
• W2009386574 cites W1513433026 @default.
• W2009386574 cites W1532492916 @default.
• W2009386574 cites W1540546146 @default.
• W2009386574 cites W1604664180 @default.
• W2009386574 cites W1616748355 @default.
• W2009386574 cites W1746095826 @default.
• W2009386574 cites W1868273134 @default.
• W2009386574 cites W1936342032 @default.
• W2009386574 cites W1939198520 @default.
• W2009386574 cites W1943067311 @default.
• W2009386574 cites W1966070964 @default.
• W2009386574 cites W1966569961 @default.
• W2009386574 cites W1967237003 @default.
• W2009386574 cites W1974363072 @default.
• W2009386574 cites W1975631280 @default.
• W2009386574 cites W1977907679 @default.
• W2009386574 cites W1979543098 @default.
• W2009386574 cites W1979964850 @default.
• W2009386574 cites W1980940171 @default.
• W2009386574 cites W1980962977 @default.
• W2009386574 cites W1983955843 @default.
• W2009386574 cites W1984331211 @default.
• W2009386574 cites W1984746596 @default.
• W2009386574 cites W1986995495 @default.
• W2009386574 cites W1987085702 @default.
• W2009386574 cites W1987145582 @default.
• W2009386574 cites W1988189150 @default.
• W2009386574 cites W1989266013 @default.
• W2009386574 cites W1989696297 @default.
• W2009386574 cites W1997496613 @default.
• W2009386574 cites W2001442825 @default.
• W2009386574 cites W2003406123 @default.
• W2009386574 cites W2004575136 @default.
• W2009386574 cites W2006392316 @default.
• W2009386574 cites W2008287057 @default.
• W2009386574 cites W2013485257 @default.
• W2009386574 cites W2013625179 @default.
• W2009386574 cites W2017577568 @default.
• W2009386574 cites W2019046972 @default.
• W2009386574 cites W2021220588 @default.
• W2009386574 cites W2021399360 @default.
• W2009386574 cites W2021766835 @default.
• W2009386574 cites W2021838768 @default.
• W2009386574 cites W2022491750 @default.
• W2009386574 cites W2023754965 @default.
• W2009386574 cites W2024667339 @default.
• W2009386574 cites W2027593703 @default.
• W2009386574 cites W2030844872 @default.
• W2009386574 cites W2032369127 @default.
• W2009386574 cites W2032920422 @default.
• W2009386574 cites W2034372853 @default.
• W2009386574 cites W2036464759 @default.
• W2009386574 cites W2036914347 @default.
• W2009386574 cites W2039220230 @default.
• W2009386574 cites W2043797153 @default.
• W2009386574 cites W2044623105 @default.
• W2009386574 cites W2045492362 @default.
• W2009386574 cites W2045649095 @default.
• W2009386574 cites W2046450144 @default.
• W2009386574 cites W2046957687 @default.
• W2009386574 cites W2052086914 @default.
• W2009386574 cites W2057717270 @default.
• W2009386574 cites W2060380545 @default.
• W2009386574 cites W2061490756 @default.
• W2009386574 cites W2065042412 @default.
• W2009386574 cites W2067198472 @default.
• W2009386574 cites W2070621825 @default.
• W2009386574 cites W2070759750 @default.
• W2009386574 cites W2076591589 @default.
• W2009386574 cites W2077494883 @default.
• W2009386574 cites W2079356804 @default.
• W2009386574 cites W2079430002 @default.
• W2009386574 cites W2080616588 @default.
• W2009386574 cites W2080931209 @default.
• W2009386574 cites W2084620265 @default.
• W2009386574 cites W2087963198 @default.
• W2009386574 cites W2088329659 @default.
• W2009386574 cites W2088559288 @default.

• next