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- W2009395852 abstract "To evaluate the potential of inverse planning technique in HDR intracavitary brachytherapy (ICRT) with conventional 2D planning technique for cervical cancer in terms of tumor coverage and toxicity profile. Ten patients of Carcinoma cervix stage IIB to IIIB, who underwent 3 sessions of ICRT at weekly interval after EBRT were included. CT/MRI compatible tandem-ovoids applicators were used. Both X-ray and CT simulation was done. Images were transferred to Plato TPS. For X-ray based planning, 7 Gy was prescribed to point A. Dose was calculated for bladder and rectal ICRU-38 points. For CT-based planning, target volume, bladder and rectum were contoured. For each patient, CT plan- Point A based (Plan A), CT plan-target based (Plan B) and IPSA plan-target based (Plan C) were generated. Total 40 plans were created. Dose received by 1 cc volume (V1), 2cc (V2), 5cc (V5) and 10cc (V10) of bladder and rectum was calculated. Volume of target that received 100%, 95% and 90% of the prescribed dose (D100), (D95) and (D90) respectively was calculated. All plans were compared. Paired-t test was used to analyze the statistical significance. For D100, difference in Plan A and Plan B was 27.3%,-25.9% and -24.7% and difference in Plan A and Plan C was -27.6%, -26.4% and -25.9% for all 3 sessions respectively (p < 0.001). For D100, interfraction difference between 1st and 2nd fraction and 1st and 3rd fraction was 1.38% and 4% respectively (p < 0.06) for Plan A;6.28% and 21.3% respectively (p < 0.001) for Plan B and 5.4% and 20% respectively (p < 0.001) for Plan C. In bladder, the difference between Plan A and Plan B was 10%, 8.6%, 6.8% and -6.18% for V1, V2, V5 and V10 respectively. The maximum interfraction difference among 3 fractions was found to be 30-32% (p < 0.001). In rectum, the difference in Plan A and Plan B were 11%, 10.3%, 9.4% and 8.5% for V1, V2, V5 and V10 respectively. The maximum interfraction difference among 3 fraction was found to be 3-5%. With reference to CT plan-Point A based, CT plan-target based was better in terms of target coverage and OAR sparing. There was no much difference in CT plan-target based and IPSA plan-target based. However, IPSA plan was superior to CT plan-Point A based. Between the 1st and 2nd fraction no significant dosimetric difference was noticed for target and bladder but the difference was significant between 1st and 3rd fractions, Rectal doses remained similar during all fractions This study points to the volumetric and dosimetric changes that occur between fractions which assumes importance especially during transition from point A based to target based treatment planning in Carcinoma Cervix." @default.
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- W2009395852 date "2010-11-01" @default.
- W2009395852 modified "2023-10-12" @default.
- W2009395852 title "CT-based Inverse Treatment Planning In HDR-intracavitary Brachytherapy for Cervical Cancer: Impact of Point A and Target-based Dosimetric and Dose Prescription Methods" @default.
- W2009395852 doi "https://doi.org/10.1016/j.ijrobp.2010.07.994" @default.
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