FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009404855> ?p ?o ?g. }

• W2009404855 endingPage "369" @default.
• W2009404855 startingPage "358" @default.
• W2009404855 abstract "Amyloid fibril formation plays a role in more than 20 diseases including Alzheimer's disease. In vitro detection of these fibrils is often performed using Thioflavin T (ThT), though the ThT binding mode is largely unknown. In the present study, spectral properties of ThT in binding environments representing beta-sheet-rich and non-beta-sheet cavities were examined. Acetylcholinesterase and gamma-cyclodextrin induced a characteristic ThT fluorescence similar to that with amyloid fibrils, whereas beta-cyclodextrin and the beta-sheet-rich transthyretin did not. The cavities of acetylcholinesterase and gamma-cyclodextrin were of similar diameter and only these cavities could accommodate two ThT ions according to molecular modelling. Binding stoichiometry studies also showed a possible binding of two ThT ions. Thus, the characteristic ThT fluorescence is induced in cavities with a diameter of 8-9A and a length able to accommodate the entire length of the ThT ion. The importance of a cavity diameter capable of binding two ThT ions, among others, indicates that an excimer formation is a plausible mechanism for the characteristic fluorescence. We propose a similar ThT binding mode in amyloid fibrils, where cavities of an appropriate size running parallel to the fibril axis have previously been proposed in several amyloid fibril models." @default.
• W2009404855 created "2016-06-24" @default.
• W2009404855 creator A5002139604 @default.
• W2009404855 creator A5018932392 @default.
• W2009404855 creator A5046853170 @default.
• W2009404855 creator A5062803042 @default.
• W2009404855 creator A5074494922 @default.
• W2009404855 creator A5079620567 @default.
• W2009404855 date "2007-06-01" @default.
• W2009404855 modified "2023-10-02" @default.
• W2009404855 title "Study on the binding of Thioflavin T to β-sheet-rich and non-β-sheet cavities" @default.
• W2009404855 cites W1253969475 @default.
• W2009404855 cites W1588296570 @default.
• W2009404855 cites W1964161207 @default.
• W2009404855 cites W1973134139 @default.
• W2009404855 cites W1973897761 @default.
• W2009404855 cites W1982356449 @default.
• W2009404855 cites W1990119527 @default.
• W2009404855 cites W1991241547 @default.
• W2009404855 cites W1993672505 @default.
• W2009404855 cites W1995247791 @default.
• W2009404855 cites W1999792674 @default.
• W2009404855 cites W2000683826 @default.
• W2009404855 cites W200778230 @default.
• W2009404855 cites W2008289288 @default.
• W2009404855 cites W2008307658 @default.
• W2009404855 cites W2008966525 @default.
• W2009404855 cites W2022927681 @default.
• W2009404855 cites W2023271753 @default.
• W2009404855 cites W2027324186 @default.
• W2009404855 cites W2028082955 @default.
• W2009404855 cites W2032758197 @default.
• W2009404855 cites W2036620149 @default.
• W2009404855 cites W2039559098 @default.
• W2009404855 cites W2041172985 @default.
• W2009404855 cites W2041655987 @default.
• W2009404855 cites W2046576999 @default.
• W2009404855 cites W2050456292 @default.
• W2009404855 cites W2058848030 @default.
• W2009404855 cites W2060495639 @default.
• W2009404855 cites W2062593465 @default.
• W2009404855 cites W2063627711 @default.
• W2009404855 cites W2066767743 @default.
• W2009404855 cites W2071579644 @default.
• W2009404855 cites W2076460435 @default.
• W2009404855 cites W2081640562 @default.
• W2009404855 cites W2082501707 @default.
• W2009404855 cites W2082658017 @default.
• W2009404855 cites W2088323113 @default.
• W2009404855 cites W2089250146 @default.
• W2009404855 cites W2093942461 @default.
• W2009404855 cites W2096425372 @default.
• W2009404855 cites W2101614182 @default.
• W2009404855 cites W2119152368 @default.
• W2009404855 cites W2121753059 @default.
• W2009404855 cites W2133130212 @default.
• W2009404855 cites W2139644513 @default.
• W2009404855 cites W2143981217 @default.
• W2009404855 cites W2154119752 @default.
• W2009404855 cites W2156984718 @default.
• W2009404855 cites W4210576276 @default.
• W2009404855 doi "https://doi.org/10.1016/j.jsb.2006.12.010" @default.
• W2009404855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17289401" @default.
• W2009404855 hasPublicationYear "2007" @default.
• W2009404855 type Work @default.
• W2009404855 sameAs 2009404855 @default.
• W2009404855 citedByCount "215" @default.
• W2009404855 countsByYear W20094048552012 @default.
• W2009404855 countsByYear W20094048552013 @default.
• W2009404855 countsByYear W20094048552014 @default.
• W2009404855 countsByYear W20094048552015 @default.
• W2009404855 countsByYear W20094048552016 @default.
• W2009404855 countsByYear W20094048552017 @default.
• W2009404855 countsByYear W20094048552018 @default.
• W2009404855 countsByYear W20094048552019 @default.
• W2009404855 countsByYear W20094048552020 @default.
• W2009404855 countsByYear W20094048552021 @default.
• W2009404855 countsByYear W20094048552022 @default.
• W2009404855 countsByYear W20094048552023 @default.
• W2009404855 crossrefType "journal-article" @default.
• W2009404855 hasAuthorship W2009404855A5002139604 @default.
• W2009404855 hasAuthorship W2009404855A5018932392 @default.
• W2009404855 hasAuthorship W2009404855A5046853170 @default.
• W2009404855 hasAuthorship W2009404855A5062803042 @default.
• W2009404855 hasAuthorship W2009404855A5074494922 @default.
• W2009404855 hasAuthorship W2009404855A5079620567 @default.
• W2009404855 hasConcept C121332964 @default.
• W2009404855 hasConcept C12554922 @default.
• W2009404855 hasConcept C142724271 @default.
• W2009404855 hasConcept C159547669 @default.
• W2009404855 hasConcept C179104552 @default.
• W2009404855 hasConcept C185592680 @default.
• W2009404855 hasConcept C27523624 @default.
• W2009404855 hasConcept C2777633098 @default.
• W2009404855 hasConcept C2778896982 @default.
• W2009404855 hasConcept C2779134260 @default.
• W2009404855 hasConcept C47701112 @default.
• W2009404855 hasConcept C502032728 @default.

• next