FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009405750> ?p ?o ?g. }

• W2009405750 endingPage "16" @default.
• W2009405750 startingPage "6" @default.
• W2009405750 abstract "HIV-1 Tat protein regulates viral gene expression by modulating the activity and association of cellular transcription factors with RNA polymerase II (RNAPII). Possible mechanisms include Tat-associated protein kinase(s) and phosphatase(s) that regulate phosphorylation of the C-terminal domain (CTD) of the large subunit of RNAPII. Hypophosphorylated RNAPII (RNAPIIa) is recruited to promoters during formation of a preinitiation complex, whereas hyperphosphorylated RNAPII (RNAPIIo) is associated with the elongation complex. The role of phosphatases in maintaining the equilibrium between the two phosphorylated states of RNAPII, which is required for sustained transcriptional activation from the HIV-1 LTR, is not clear. In this study, we discuss the properties of a Tat-associated CTD phosphatase fractionated from Jurkat T cells. The Tat-associated protein phosphatase (TAPP) is related to the serine/threonine, type 1, protein phosphatase (PP1) family. TAPP dephosphorylates the hyperphosphorylated form of recombinant CTD specifically on serine 2, and augments Tat-mediated transcriptional transactivation of HIV-1 LTR in an in vitro transcription reaction. TAPP is associated with the transcription complex during the early initiation steps, and its release from the HIV-1 promoter coincides with the Tat-specific activation of CDK9. The results suggest a unique role of the Tat-associated phosphatase which regulates viral transcription by target-specific dephosphorylation of RNAPII during the early stages of elongation." @default.
• W2009405750 created "2016-06-24" @default.
• W2009405750 creator A5025205189 @default.
• W2009405750 creator A5058116407 @default.
• W2009405750 creator A5059010908 @default.
• W2009405750 creator A5079777629 @default.
• W2009405750 creator A5080278598 @default.
• W2009405750 creator A5088442814 @default.
• W2009405750 date "2002-04-01" @default.
• W2009405750 modified "2023-10-17" @default.
• W2009405750 title "A Protein Phosphatase from Human T Cells Augments Tat Transactivation of the Human Immunodeficiency Virus Type 1 Long-Terminal Repeat" @default.
• W2009405750 cites W1268592555 @default.
• W2009405750 cites W1526768794 @default.
• W2009405750 cites W1581101118 @default.
• W2009405750 cites W1606267994 @default.
• W2009405750 cites W1965591721 @default.
• W2009405750 cites W1970977612 @default.
• W2009405750 cites W1971292289 @default.
• W2009405750 cites W1972920876 @default.
• W2009405750 cites W1978588563 @default.
• W2009405750 cites W1986427733 @default.
• W2009405750 cites W1988646837 @default.
• W2009405750 cites W1993243592 @default.
• W2009405750 cites W1996072788 @default.
• W2009405750 cites W2002806722 @default.
• W2009405750 cites W2003168089 @default.
• W2009405750 cites W2015372299 @default.
• W2009405750 cites W2021397335 @default.
• W2009405750 cites W2030180039 @default.
• W2009405750 cites W2037556124 @default.
• W2009405750 cites W2046091591 @default.
• W2009405750 cites W2046854154 @default.
• W2009405750 cites W2050682981 @default.
• W2009405750 cites W2054266435 @default.
• W2009405750 cites W2066534222 @default.
• W2009405750 cites W2069869908 @default.
• W2009405750 cites W2072836045 @default.
• W2009405750 cites W2076100163 @default.
• W2009405750 cites W2079489048 @default.
• W2009405750 cites W2082797919 @default.
• W2009405750 cites W2089768147 @default.
• W2009405750 cites W2091250415 @default.
• W2009405750 cites W2095839679 @default.
• W2009405750 cites W2126730534 @default.
• W2009405750 cites W2135736528 @default.
• W2009405750 cites W2137256186 @default.
• W2009405750 cites W2144028057 @default.
• W2009405750 cites W2148330261 @default.
• W2009405750 cites W2156403775 @default.
• W2009405750 cites W2169963834 @default.
• W2009405750 cites W2171252684 @default.
• W2009405750 cites W2178456244 @default.
• W2009405750 cites W223364330 @default.
• W2009405750 cites W4211084625 @default.
• W2009405750 doi "https://doi.org/10.1006/viro.2002.1438" @default.
• W2009405750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12036313" @default.
• W2009405750 hasPublicationYear "2002" @default.
• W2009405750 type Work @default.
• W2009405750 sameAs 2009405750 @default.
• W2009405750 citedByCount "18" @default.
• W2009405750 countsByYear W20094057502014 @default.
• W2009405750 countsByYear W20094057502016 @default.
• W2009405750 countsByYear W20094057502022 @default.
• W2009405750 crossrefType "journal-article" @default.
• W2009405750 hasAuthorship W2009405750A5025205189 @default.
• W2009405750 hasAuthorship W2009405750A5058116407 @default.
• W2009405750 hasAuthorship W2009405750A5059010908 @default.
• W2009405750 hasAuthorship W2009405750A5079777629 @default.
• W2009405750 hasAuthorship W2009405750A5080278598 @default.
• W2009405750 hasAuthorship W2009405750A5088442814 @default.
• W2009405750 hasBestOaLocation W20094057501 @default.
• W2009405750 hasConcept C101762097 @default.
• W2009405750 hasConcept C104292427 @default.
• W2009405750 hasConcept C104317684 @default.
• W2009405750 hasConcept C11960822 @default.
• W2009405750 hasConcept C1292079 @default.
• W2009405750 hasConcept C138885662 @default.
• W2009405750 hasConcept C150194340 @default.
• W2009405750 hasConcept C153911025 @default.
• W2009405750 hasConcept C178666793 @default.
• W2009405750 hasConcept C179464577 @default.
• W2009405750 hasConcept C179926584 @default.
• W2009405750 hasConcept C181912034 @default.
• W2009405750 hasConcept C184235292 @default.
• W2009405750 hasConcept C199491388 @default.
• W2009405750 hasConcept C2776090121 @default.
• W2009405750 hasConcept C2779408958 @default.
• W2009405750 hasConcept C389152 @default.
• W2009405750 hasConcept C41895202 @default.
• W2009405750 hasConcept C54355233 @default.
• W2009405750 hasConcept C55493867 @default.
• W2009405750 hasConcept C64350747 @default.
• W2009405750 hasConcept C86339819 @default.
• W2009405750 hasConcept C86803240 @default.
• W2009405750 hasConcept C8891405 @default.
• W2009405750 hasConcept C95444343 @default.
• W2009405750 hasConceptScore W2009405750C101762097 @default.
• W2009405750 hasConceptScore W2009405750C104292427 @default.

• next