Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009409188> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2009409188 endingPage "918" @default.
- W2009409188 startingPage "913" @default.
- W2009409188 abstract "Extended-release theophylline (TP) matrix tablets were prepared by direct compression of drug and different pH-dependent (Eudragit L100, S100 and L100-55) and pH-independent (Eudragit RLPO and RSPO) polymer combinations. The influence of varying the polymer/polymer (w/w) ratio and the drug incorporation method (simple blend or solid dispersion) was also evaluated. Drug release, monitored using the Through Flow Cell system, markedly depended on both the kind of Eudragit polymer combinations used and their relative content in the matrix. Maintaining a constant 1:1 (w/w) drug/polymers ratio, the selection of appropriate mixtures of pH-dependent and pH-independent polymers enabled achievement of a suitable control of TP release. In particular, matrices with a 0.7:0.3 w/w mixture of Eudragit L100-Eudragit RLPO showed highly reproducible drug release profiles, with an almost zero-order kinetic, and allowed 100% released drug after 360 min. As for the effect of the drug incorporation method, simple blending was better than the solid dispersion technique, which not only did not improve the release data reproducibility, but also caused, unexpectedly, a marked slowing down in drug release rate." @default.
- W2009409188 created "2016-06-24" @default.
- W2009409188 creator A5032496450 @default.
- W2009409188 creator A5042287581 @default.
- W2009409188 creator A5050895361 @default.
- W2009409188 creator A5066280195 @default.
- W2009409188 creator A5080558494 @default.
- W2009409188 date "2005-11-01" @default.
- W2009409188 modified "2023-10-12" @default.
- W2009409188 title "Influence of formulation and process variables on in vitro release of theophylline from directly-compressed Eudragit matrix tablets" @default.
- W2009409188 cites W1974324005 @default.
- W2009409188 cites W1977546757 @default.
- W2009409188 cites W2010254902 @default.
- W2009409188 cites W2020400505 @default.
- W2009409188 cites W2036126407 @default.
- W2009409188 cites W2063252534 @default.
- W2009409188 cites W2068845226 @default.
- W2009409188 cites W2070905664 @default.
- W2009409188 cites W2074814364 @default.
- W2009409188 cites W2077076099 @default.
- W2009409188 cites W2083583883 @default.
- W2009409188 cites W2094089128 @default.
- W2009409188 cites W2151114776 @default.
- W2009409188 doi "https://doi.org/10.1016/j.farmac.2005.07.002" @default.
- W2009409188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16129436" @default.
- W2009409188 hasPublicationYear "2005" @default.
- W2009409188 type Work @default.
- W2009409188 sameAs 2009409188 @default.
- W2009409188 citedByCount "88" @default.
- W2009409188 countsByYear W20094091882012 @default.
- W2009409188 countsByYear W20094091882013 @default.
- W2009409188 countsByYear W20094091882014 @default.
- W2009409188 countsByYear W20094091882015 @default.
- W2009409188 countsByYear W20094091882016 @default.
- W2009409188 countsByYear W20094091882017 @default.
- W2009409188 countsByYear W20094091882018 @default.
- W2009409188 countsByYear W20094091882019 @default.
- W2009409188 countsByYear W20094091882020 @default.
- W2009409188 countsByYear W20094091882021 @default.
- W2009409188 countsByYear W20094091882022 @default.
- W2009409188 countsByYear W20094091882023 @default.
- W2009409188 crossrefType "journal-article" @default.
- W2009409188 hasAuthorship W2009409188A5032496450 @default.
- W2009409188 hasAuthorship W2009409188A5042287581 @default.
- W2009409188 hasAuthorship W2009409188A5050895361 @default.
- W2009409188 hasAuthorship W2009409188A5066280195 @default.
- W2009409188 hasAuthorship W2009409188A5080558494 @default.
- W2009409188 hasConcept C106487976 @default.
- W2009409188 hasConcept C120665830 @default.
- W2009409188 hasConcept C121332964 @default.
- W2009409188 hasConcept C127413603 @default.
- W2009409188 hasConcept C177562468 @default.
- W2009409188 hasConcept C178790620 @default.
- W2009409188 hasConcept C185592680 @default.
- W2009409188 hasConcept C2778095195 @default.
- W2009409188 hasConcept C42360764 @default.
- W2009409188 hasConcept C43617362 @default.
- W2009409188 hasConcept C521977710 @default.
- W2009409188 hasConcept C71924100 @default.
- W2009409188 hasConcept C77281830 @default.
- W2009409188 hasConcept C98274493 @default.
- W2009409188 hasConceptScore W2009409188C106487976 @default.
- W2009409188 hasConceptScore W2009409188C120665830 @default.
- W2009409188 hasConceptScore W2009409188C121332964 @default.
- W2009409188 hasConceptScore W2009409188C127413603 @default.
- W2009409188 hasConceptScore W2009409188C177562468 @default.
- W2009409188 hasConceptScore W2009409188C178790620 @default.
- W2009409188 hasConceptScore W2009409188C185592680 @default.
- W2009409188 hasConceptScore W2009409188C2778095195 @default.
- W2009409188 hasConceptScore W2009409188C42360764 @default.
- W2009409188 hasConceptScore W2009409188C43617362 @default.
- W2009409188 hasConceptScore W2009409188C521977710 @default.
- W2009409188 hasConceptScore W2009409188C71924100 @default.
- W2009409188 hasConceptScore W2009409188C77281830 @default.
- W2009409188 hasConceptScore W2009409188C98274493 @default.
- W2009409188 hasIssue "11-12" @default.
- W2009409188 hasLocation W20094091881 @default.
- W2009409188 hasLocation W20094091882 @default.
- W2009409188 hasOpenAccess W2009409188 @default.
- W2009409188 hasPrimaryLocation W20094091881 @default.
- W2009409188 hasRelatedWork W1469096184 @default.
- W2009409188 hasRelatedWork W1977649247 @default.
- W2009409188 hasRelatedWork W2061140153 @default.
- W2009409188 hasRelatedWork W2091818840 @default.
- W2009409188 hasRelatedWork W2140725853 @default.
- W2009409188 hasRelatedWork W2319698807 @default.
- W2009409188 hasRelatedWork W2420613639 @default.
- W2009409188 hasRelatedWork W2472660848 @default.
- W2009409188 hasRelatedWork W2904348443 @default.
- W2009409188 hasRelatedWork W2982584908 @default.
- W2009409188 hasVolume "60" @default.
- W2009409188 isParatext "false" @default.
- W2009409188 isRetracted "false" @default.
- W2009409188 magId "2009409188" @default.
- W2009409188 workType "article" @default.