FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009423858> ?p ?o ?g. }

• W2009423858 endingPage "37" @default.
• W2009423858 startingPage "27" @default.
• W2009423858 abstract "Pathogenic Leptospira spp. causes leptospirosis in China and throughout the world. Here, we have sequenced two L. interrogans moderately virulent vaccine strains JDL03 (serovar Canicola) and JDL10 (serovar Hebdomadis) used in China. We selected a subproteomic approach to identify surface-exposed proteins including OMPs and extracellular proteins of these two strains plus a highly virulent vaccine strain 56601 (serovar Lai). Comparative surface-exposed proteome among the three strains indicated 81 cores, 61 dispensable and 122 unique surface-exposed proteins. Finally, the 10 highly conserved surface-exposed or subsurface proteins included two known cross-reactive antigens (LipL32 and LA_3469) and another two novel antigens (LA_0136 and LA_0505) displaying conserved immunoreactivity among 15 Chinese epidemic serovars. Furthermore, many potential virulence factors were detected in these identified surface-exposed proteins, such as Loa22, LipL32, LenC, LenF and OmpL37. Interestingly, LipL45, ClpA and ClpB, exhibiting obvious amino acid mutations among str.56601, str.JDL03 and JDL10, might contribute to virulence differences observed among these strains. Additionally, specific surface-exposed proteins in virulent str.56601 were considered to be key virulence determinants, such as Zn-dependent protease, cholesterol oxidase precursor, and so on. In all, we had relatively complete surface-exposed subproteomes of L. interrogans, which will enhance our understanding of leptospiral pathogenesis and key virulence determinants. The present work demonstrates the use of genomic sequencing and subproteomic studies for the identification of potential vaccine and diagnostic antigen candidates against leptospirosis. The data show the conserved surface-exposed proteins to be novel potentially vaccine/diagnostic candidates. Furthermore, the data also show that LipL45, ClpA, ClpB and a lipoprotein from these three strains plus another highly virulent strain Fiocruz L1-130 contain specific amino acid mutations in strains JDL03 and JDL10. The surface-exposed subproteome of pathogenic L. interrogans could provide valuable information to gain a more complete understanding of leptospiral pathogenesis and virulence determinants." @default.
• W2009423858 created "2016-06-24" @default.
• W2009423858 creator A5008989960 @default.
• W2009423858 creator A5012610482 @default.
• W2009423858 creator A5015568621 @default.
• W2009423858 creator A5015956734 @default.
• W2009423858 creator A5022873874 @default.
• W2009423858 creator A5026312898 @default.
• W2009423858 creator A5041836364 @default.
• W2009423858 creator A5055514145 @default.
• W2009423858 creator A5063549313 @default.
• W2009423858 creator A5070044084 @default.
• W2009423858 creator A5074482348 @default.
• W2009423858 creator A5086509214 @default.
• W2009423858 date "2015-01-01" @default.
• W2009423858 modified "2023-10-16" @default.
• W2009423858 title "Comparative subproteome analysis of three representative Leptospira interrogans vaccine strains reveals cross-reactive antigens and novel virulence determinants" @default.
• W2009423858 cites W1505391368 @default.
• W2009423858 cites W1506435375 @default.
• W2009423858 cites W1903711323 @default.
• W2009423858 cites W1916304512 @default.
• W2009423858 cites W1967284543 @default.
• W2009423858 cites W1968038892 @default.
• W2009423858 cites W1968653622 @default.
• W2009423858 cites W1971321218 @default.
• W2009423858 cites W1975988720 @default.
• W2009423858 cites W1976334605 @default.
• W2009423858 cites W1977411763 @default.
• W2009423858 cites W1981533716 @default.
• W2009423858 cites W1984244995 @default.
• W2009423858 cites W1986055146 @default.
• W2009423858 cites W1986708244 @default.
• W2009423858 cites W2010526430 @default.
• W2009423858 cites W2014532770 @default.
• W2009423858 cites W2030163044 @default.
• W2009423858 cites W2032785468 @default.
• W2009423858 cites W2035126911 @default.
• W2009423858 cites W2037654995 @default.
• W2009423858 cites W2045309021 @default.
• W2009423858 cites W2047255625 @default.
• W2009423858 cites W2050421189 @default.
• W2009423858 cites W2054743418 @default.
• W2009423858 cites W2057472819 @default.
• W2009423858 cites W2059580467 @default.
• W2009423858 cites W2064461883 @default.
• W2009423858 cites W2070407853 @default.
• W2009423858 cites W2074068865 @default.
• W2009423858 cites W2091076696 @default.
• W2009423858 cites W2092251498 @default.
• W2009423858 cites W2092759212 @default.
• W2009423858 cites W2093215713 @default.
• W2009423858 cites W2095711258 @default.
• W2009423858 cites W2097771231 @default.
• W2009423858 cites W2099416536 @default.
• W2009423858 cites W2102196014 @default.
• W2009423858 cites W2103694860 @default.
• W2009423858 cites W2103764811 @default.
• W2009423858 cites W2105199251 @default.
• W2009423858 cites W2105478527 @default.
• W2009423858 cites W2106202218 @default.
• W2009423858 cites W2109093460 @default.
• W2009423858 cites W2116931701 @default.
• W2009423858 cites W2119969992 @default.
• W2009423858 cites W2128114769 @default.
• W2009423858 cites W2128682436 @default.
• W2009423858 cites W2144814170 @default.
• W2009423858 cites W2145480569 @default.
• W2009423858 cites W2154594710 @default.
• W2009423858 cites W2155606054 @default.
• W2009423858 cites W2162198166 @default.
• W2009423858 cites W2163356825 @default.
• W2009423858 cites W2164154943 @default.
• W2009423858 cites W2166458547 @default.
• W2009423858 cites W2168441823 @default.
• W2009423858 cites W2320652711 @default.
• W2009423858 doi "https://doi.org/10.1016/j.jprot.2014.08.015" @default.
• W2009423858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25201075" @default.
• W2009423858 hasPublicationYear "2015" @default.
• W2009423858 type Work @default.
• W2009423858 sameAs 2009423858 @default.
• W2009423858 citedByCount "8" @default.
• W2009423858 countsByYear W20094238582015 @default.
• W2009423858 countsByYear W20094238582017 @default.
• W2009423858 countsByYear W20094238582018 @default.
• W2009423858 countsByYear W20094238582019 @default.
• W2009423858 countsByYear W20094238582022 @default.
• W2009423858 crossrefType "journal-article" @default.
• W2009423858 hasAuthorship W2009423858A5008989960 @default.
• W2009423858 hasAuthorship W2009423858A5012610482 @default.
• W2009423858 hasAuthorship W2009423858A5015568621 @default.
• W2009423858 hasAuthorship W2009423858A5015956734 @default.
• W2009423858 hasAuthorship W2009423858A5022873874 @default.
• W2009423858 hasAuthorship W2009423858A5026312898 @default.
• W2009423858 hasAuthorship W2009423858A5041836364 @default.
• W2009423858 hasAuthorship W2009423858A5055514145 @default.
• W2009423858 hasAuthorship W2009423858A5063549313 @default.
• W2009423858 hasAuthorship W2009423858A5070044084 @default.
• W2009423858 hasAuthorship W2009423858A5074482348 @default.

• next