FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009425656> ?p ?o ?g. }

• W2009425656 endingPage "266" @default.
• W2009425656 startingPage "260" @default.
• W2009425656 abstract "Sedative-hypnotic drugs commonly used in the elderly may affect functional recovery following cerebrovascular events. Previous research has shown that prolonged exposure to diazepam can interfere with recovery of function and exaggerate tissue loss after brain injury. The present study evaluated the effect of zopiclone, a widely used hypnotic drug, on functional and histological outcome after cortical photothrombosis in aged rats, which might be particularly vulnerable to brain insults and inhibitory sedative-hypnotic drugs. Aged Wistar rats were treated with zopiclone at a dose of 3 mg/kg (i.p., once a day) beginning 4 days before ischemia induction and continuing for 23 days. Sensorimotor recovery was assessed by a new ledged beam-walking test and spatial learning by the Morris water-maze. After a 7-day washout period all rats were administered a single dose of zopiclone (3 mg/kg, i.p.) and retested. Infarct volumes were measured from nitroblue tetrazolium-stained sections at the end of the experiment. Beam-walking data showed that ischemic rats treated with zopiclone were not more impaired than untreated rats. Indeed, they showed fewer faults with the impaired hindlimb than ischemic controls on post-operative day 16. Water-maze performance was not affected by zopiclone. After the washout period a single dose of zopiclone did not worsen forelimb or hindlimb function, but seemed to improve performance in the water-maze test. Cortical infarct volumes were similar in ischemic controls and ischemic rats treated with zopiclone. In conclusion, zopiclone was not detrimental and even seemed to improve behavioral outcome without affecting ischemic damage in aged rats subjected to cortical photothrombosis." @default.
• W2009425656 created "2016-06-24" @default.
• W2009425656 creator A5017816148 @default.
• W2009425656 creator A5018256053 @default.
• W2009425656 creator A5043751479 @default.
• W2009425656 creator A5087782377 @default.
• W2009425656 creator A5091902514 @default.
• W2009425656 date "2005-05-01" @default.
• W2009425656 modified "2023-10-03" @default.
• W2009425656 title "Behavioral effects of photothrombotic ischemic cortical injury in aged rats treated with the sedative-hypnotic GABAergic drug zopiclone" @default.
• W2009425656 cites W1539097584 @default.
• W2009425656 cites W1626208403 @default.
• W2009425656 cites W1656112413 @default.
• W2009425656 cites W1967110731 @default.
• W2009425656 cites W1971789030 @default.
• W2009425656 cites W1975761280 @default.
• W2009425656 cites W1979528683 @default.
• W2009425656 cites W1983068389 @default.
• W2009425656 cites W1983532871 @default.
• W2009425656 cites W1998392378 @default.
• W2009425656 cites W2006771521 @default.
• W2009425656 cites W2007676763 @default.
• W2009425656 cites W2008108982 @default.
• W2009425656 cites W2011668146 @default.
• W2009425656 cites W2019755331 @default.
• W2009425656 cites W2022374946 @default.
• W2009425656 cites W2024060726 @default.
• W2009425656 cites W2030767981 @default.
• W2009425656 cites W2035328388 @default.
• W2009425656 cites W2040031347 @default.
• W2009425656 cites W2048431655 @default.
• W2009425656 cites W2053734785 @default.
• W2009425656 cites W2054760165 @default.
• W2009425656 cites W2057983596 @default.
• W2009425656 cites W2058281760 @default.
• W2009425656 cites W2058537437 @default.
• W2009425656 cites W2063045558 @default.
• W2009425656 cites W2064097963 @default.
• W2009425656 cites W2065471308 @default.
• W2009425656 cites W2072743691 @default.
• W2009425656 cites W2072897782 @default.
• W2009425656 cites W2082523284 @default.
• W2009425656 cites W2082830396 @default.
• W2009425656 cites W2082895324 @default.
• W2009425656 cites W2087804543 @default.
• W2009425656 cites W2087992743 @default.
• W2009425656 cites W2088083260 @default.
• W2009425656 cites W2089451037 @default.
• W2009425656 cites W2091839957 @default.
• W2009425656 cites W2092670901 @default.
• W2009425656 cites W2105099612 @default.
• W2009425656 cites W2106183836 @default.
• W2009425656 cites W2125481891 @default.
• W2009425656 cites W2139176680 @default.
• W2009425656 cites W2153891187 @default.
• W2009425656 cites W2171187231 @default.
• W2009425656 doi "https://doi.org/10.1016/j.bbr.2004.12.007" @default.
• W2009425656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15863222" @default.
• W2009425656 hasPublicationYear "2005" @default.
• W2009425656 type Work @default.
• W2009425656 sameAs 2009425656 @default.
• W2009425656 citedByCount "22" @default.
• W2009425656 countsByYear W20094256562012 @default.
• W2009425656 countsByYear W20094256562013 @default.
• W2009425656 countsByYear W20094256562014 @default.
• W2009425656 countsByYear W20094256562016 @default.
• W2009425656 countsByYear W20094256562017 @default.
• W2009425656 countsByYear W20094256562018 @default.
• W2009425656 crossrefType "journal-article" @default.
• W2009425656 hasAuthorship W2009425656A5017816148 @default.
• W2009425656 hasAuthorship W2009425656A5018256053 @default.
• W2009425656 hasAuthorship W2009425656A5043751479 @default.
• W2009425656 hasAuthorship W2009425656A5087782377 @default.
• W2009425656 hasAuthorship W2009425656A5091902514 @default.
• W2009425656 hasConcept C126322002 @default.
• W2009425656 hasConcept C15744967 @default.
• W2009425656 hasConcept C2776175493 @default.
• W2009425656 hasConcept C2777602617 @default.
• W2009425656 hasConcept C2777810057 @default.
• W2009425656 hasConcept C2780930544 @default.
• W2009425656 hasConcept C2781161787 @default.
• W2009425656 hasConcept C2910067630 @default.
• W2009425656 hasConcept C42219234 @default.
• W2009425656 hasConcept C44752575 @default.
• W2009425656 hasConcept C71924100 @default.
• W2009425656 hasConcept C98274493 @default.
• W2009425656 hasConceptScore W2009425656C126322002 @default.
• W2009425656 hasConceptScore W2009425656C15744967 @default.
• W2009425656 hasConceptScore W2009425656C2776175493 @default.
• W2009425656 hasConceptScore W2009425656C2777602617 @default.
• W2009425656 hasConceptScore W2009425656C2777810057 @default.
• W2009425656 hasConceptScore W2009425656C2780930544 @default.
• W2009425656 hasConceptScore W2009425656C2781161787 @default.
• W2009425656 hasConceptScore W2009425656C2910067630 @default.
• W2009425656 hasConceptScore W2009425656C42219234 @default.
• W2009425656 hasConceptScore W2009425656C44752575 @default.
• W2009425656 hasConceptScore W2009425656C71924100 @default.
• W2009425656 hasConceptScore W2009425656C98274493 @default.

• next