FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009432885> ?p ?o ?g. }

• W2009432885 endingPage "1283" @default.
• W2009432885 startingPage "1278" @default.
• W2009432885 abstract "Castration of normal male rodents results in significant enlargement of the thymus, and androgen replacement reverses these changes. Androgen-resistant testicular feminization (Tfm) mice also show significant thymus enlargement, which suggests that these changes are mediated by the androgen receptor (AR). The cellular targets of androgen action in the thymus are not known, but may include the lymphoid cells (thymocytes) as well as nonlymphoid epithelial cells, both of which have been believed to express AR. In the present study immunohistochemical analysis and hormone binding assays were used to demonstrate the presence of AR in thymic epithelial cells. The physiological significance of this epithelial cell AR expression was defined by further studies performed in vivo using chimeric mice, produced by bone marrow transplantation, in which AR expression was limited to either lymphoid or epithelial components of the thymus. Chimeric C57 mice engrafted with Tfm bone marrow cells (AR(+) epithelium and AR(-) thymocytes) had thymuses of normal size and showed the normal involutional response to androgens, whereas chimeric Tfm mice engrafted with C57 bone marrow cells (AR(-) epithelium and AR(+) thymocytes) showed thymus enlargement and androgen insensitivity. Furthermore, phenotypic analyses of lymphocytes in mice with AR(-) thymic epithelium showed abrogation of the normal responses to androgens. These data suggest that AR expressed by thymic epithelium are important modulators of thymocyte development." @default.
• W2009432885 created "2016-06-24" @default.
• W2009432885 creator A5006712935 @default.
• W2009432885 creator A5029643203 @default.
• W2009432885 creator A5035534167 @default.
• W2009432885 creator A5039106210 @default.
• W2009432885 creator A5050060955 @default.
• W2009432885 date "2001-03-01" @default.
• W2009432885 modified "2023-10-01" @default.
• W2009432885 title "Androgen Receptors in Thymic Epithelium Modulate Thymus Size and Thymocyte Development*" @default.
• W2009432885 cites W1554595160 @default.
• W2009432885 cites W1556880785 @default.
• W2009432885 cites W1589679215 @default.
• W2009432885 cites W1592056735 @default.
• W2009432885 cites W1964056343 @default.
• W2009432885 cites W1970300292 @default.
• W2009432885 cites W1974667009 @default.
• W2009432885 cites W1979522921 @default.
• W2009432885 cites W1980458304 @default.
• W2009432885 cites W1992213144 @default.
• W2009432885 cites W2003819161 @default.
• W2009432885 cites W2004947704 @default.
• W2009432885 cites W2007801101 @default.
• W2009432885 cites W2013756987 @default.
• W2009432885 cites W2025487748 @default.
• W2009432885 cites W2027385741 @default.
• W2009432885 cites W2032903055 @default.
• W2009432885 cites W2034938926 @default.
• W2009432885 cites W2049722388 @default.
• W2009432885 cites W2050198445 @default.
• W2009432885 cites W2050572513 @default.
• W2009432885 cites W2059118460 @default.
• W2009432885 cites W2067739358 @default.
• W2009432885 cites W2088561119 @default.
• W2009432885 cites W2125165410 @default.
• W2009432885 cites W2140916758 @default.
• W2009432885 cites W2145982399 @default.
• W2009432885 cites W2147566707 @default.
• W2009432885 cites W2169576592 @default.
• W2009432885 cites W2173291795 @default.
• W2009432885 cites W2174800991 @default.
• W2009432885 cites W4313347829 @default.
• W2009432885 doi "https://doi.org/10.1210/endo.142.3.8032" @default.
• W2009432885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11181545" @default.
• W2009432885 hasPublicationYear "2001" @default.
• W2009432885 type Work @default.
• W2009432885 sameAs 2009432885 @default.
• W2009432885 citedByCount "185" @default.
• W2009432885 countsByYear W20094328852012 @default.
• W2009432885 countsByYear W20094328852013 @default.
• W2009432885 countsByYear W20094328852014 @default.
• W2009432885 countsByYear W20094328852015 @default.
• W2009432885 countsByYear W20094328852016 @default.
• W2009432885 countsByYear W20094328852017 @default.
• W2009432885 countsByYear W20094328852018 @default.
• W2009432885 countsByYear W20094328852019 @default.
• W2009432885 countsByYear W20094328852020 @default.
• W2009432885 countsByYear W20094328852021 @default.
• W2009432885 countsByYear W20094328852022 @default.
• W2009432885 countsByYear W20094328852023 @default.
• W2009432885 crossrefType "journal-article" @default.
• W2009432885 hasAuthorship W2009432885A5006712935 @default.
• W2009432885 hasAuthorship W2009432885A5029643203 @default.
• W2009432885 hasAuthorship W2009432885A5035534167 @default.
• W2009432885 hasAuthorship W2009432885A5039106210 @default.
• W2009432885 hasAuthorship W2009432885A5050060955 @default.
• W2009432885 hasBestOaLocation W20094328851 @default.
• W2009432885 hasConcept C109159458 @default.
• W2009432885 hasConcept C121608353 @default.
• W2009432885 hasConcept C126322002 @default.
• W2009432885 hasConcept C134018914 @default.
• W2009432885 hasConcept C170493617 @default.
• W2009432885 hasConcept C203014093 @default.
• W2009432885 hasConcept C204232928 @default.
• W2009432885 hasConcept C2776090121 @default.
• W2009432885 hasConcept C2777911890 @default.
• W2009432885 hasConcept C2778954852 @default.
• W2009432885 hasConcept C2780007613 @default.
• W2009432885 hasConcept C2780192828 @default.
• W2009432885 hasConcept C28328180 @default.
• W2009432885 hasConcept C2911091166 @default.
• W2009432885 hasConcept C3019229404 @default.
• W2009432885 hasConcept C529295009 @default.
• W2009432885 hasConcept C54355233 @default.
• W2009432885 hasConcept C61367390 @default.
• W2009432885 hasConcept C71315377 @default.
• W2009432885 hasConcept C71924100 @default.
• W2009432885 hasConcept C79904392 @default.
• W2009432885 hasConcept C86803240 @default.
• W2009432885 hasConcept C8891405 @default.
• W2009432885 hasConcept C95444343 @default.
• W2009432885 hasConceptScore W2009432885C109159458 @default.
• W2009432885 hasConceptScore W2009432885C121608353 @default.
• W2009432885 hasConceptScore W2009432885C126322002 @default.
• W2009432885 hasConceptScore W2009432885C134018914 @default.
• W2009432885 hasConceptScore W2009432885C170493617 @default.
• W2009432885 hasConceptScore W2009432885C203014093 @default.
• W2009432885 hasConceptScore W2009432885C204232928 @default.

• next