FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009435973> ?p ?o ?g. }

• W2009435973 endingPage "212" @default.
• W2009435973 startingPage "206" @default.
• W2009435973 abstract "Much evidence indicates that increased persistent sodium current (INa.P) is associated with cellular calcium overload and INa.P is considered to be a potential target for therapeutic intervention in ischaemia and heart failure. By inhibiting type III phosphodiesterase, milrinone increases intracellular cyclic adenosine monophosphate (cAMP), with a positive inotropic effect. However, the effect of milrinone on increased INa.P under pathological conditions remains unknown. Accordingly, we investigated the effect of milrinone on increased INa.P induced by hypoxia or hydrogen dioxide in guinea pig ventricular myocytes. While milrinone (0.01 mM or 0.1 mM) or cAMP (0.1 mM) decreased INa.P respectively in control condition, application of 1 μM H-89, a selective cAMP-dependant protein kinase inhibitor, prevented the effect of 0.1 mM milrinone in control condition. Milrinone (0.1 mM) reduced the increased INa.P induced by hypoxia. Furthermore, 0.01 mM or 0.1 mM milrinone reduced the enhanced INa.P induced by 0.3 mM hydrogen peroxide. In addition, 0.01 mM or 0.1 mM milrinone shortened action potential duration at 90% repolarization (APD90). Bath application of 0.3 mM hydrogen dioxide markedly prolonged APD90, while 2 μM tetrodotoxin (TTX) reversed the prolonged APD90. In the other two groups, 0.01 mM or 0.1 mM milrinone shortened the prolonged APD90 induced by 0.3 mM hydrogen peroxide, ultimately 2 μM TTX causing a further decurtation of APD90. These findings demonstrate that milrinone inhibited INa.P under normal condition, hypoxia or hydrogen dioxide-induced INa.P, and the APD90 prolonged by hydrogen dioxide-induced INa.P in ventricular myocytes, which is associated with the mechanism of milrinone increasing intracellular cAMP." @default.
• W2009435973 created "2016-06-24" @default.
• W2009435973 creator A5006655487 @default.
• W2009435973 creator A5006988369 @default.
• W2009435973 creator A5023179804 @default.
• W2009435973 creator A5026391347 @default.
• W2009435973 creator A5057948544 @default.
• W2009435973 creator A5090283553 @default.
• W2009435973 date "2009-08-01" @default.
• W2009435973 modified "2023-09-30" @default.
• W2009435973 title "Milrinone inhibits hypoxia or hydrogen dioxide-induced persistent sodium current in ventricular myocytes" @default.
• W2009435973 cites W1965387104 @default.
• W2009435973 cites W1969882738 @default.
• W2009435973 cites W1982453352 @default.
• W2009435973 cites W1983854682 @default.
• W2009435973 cites W1986756807 @default.
• W2009435973 cites W1987693704 @default.
• W2009435973 cites W1990221186 @default.
• W2009435973 cites W1991325480 @default.
• W2009435973 cites W1994212877 @default.
• W2009435973 cites W1995915714 @default.
• W2009435973 cites W2001055298 @default.
• W2009435973 cites W2003067558 @default.
• W2009435973 cites W2013524192 @default.
• W2009435973 cites W2014477154 @default.
• W2009435973 cites W2020063160 @default.
• W2009435973 cites W2020355975 @default.
• W2009435973 cites W2029366322 @default.
• W2009435973 cites W2041299143 @default.
• W2009435973 cites W2041853273 @default.
• W2009435973 cites W2042503097 @default.
• W2009435973 cites W2045278682 @default.
• W2009435973 cites W2062020346 @default.
• W2009435973 cites W2063954755 @default.
• W2009435973 cites W2068189586 @default.
• W2009435973 cites W2068483283 @default.
• W2009435973 cites W2076928581 @default.
• W2009435973 cites W2077952574 @default.
• W2009435973 cites W2085802769 @default.
• W2009435973 cites W2086626880 @default.
• W2009435973 cites W2087302417 @default.
• W2009435973 cites W2102552083 @default.
• W2009435973 cites W2111040016 @default.
• W2009435973 cites W2111821712 @default.
• W2009435973 cites W2133789746 @default.
• W2009435973 cites W2140838251 @default.
• W2009435973 cites W2141900287 @default.
• W2009435973 cites W2145649316 @default.
• W2009435973 cites W2151378419 @default.
• W2009435973 cites W2154057850 @default.
• W2009435973 cites W2156850492 @default.
• W2009435973 cites W2298979802 @default.
• W2009435973 cites W2314816016 @default.
• W2009435973 cites W2337457656 @default.
• W2009435973 cites W2401933974 @default.
• W2009435973 cites W4249217681 @default.
• W2009435973 doi "https://doi.org/10.1016/j.ejphar.2009.06.021" @default.
• W2009435973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19549513" @default.
• W2009435973 hasPublicationYear "2009" @default.
• W2009435973 type Work @default.
• W2009435973 sameAs 2009435973 @default.
• W2009435973 citedByCount "14" @default.
• W2009435973 countsByYear W20094359732012 @default.
• W2009435973 countsByYear W20094359732013 @default.
• W2009435973 countsByYear W20094359732014 @default.
• W2009435973 countsByYear W20094359732015 @default.
• W2009435973 countsByYear W20094359732017 @default.
• W2009435973 countsByYear W20094359732018 @default.
• W2009435973 countsByYear W20094359732019 @default.
• W2009435973 countsByYear W20094359732020 @default.
• W2009435973 countsByYear W20094359732021 @default.
• W2009435973 countsByYear W20094359732022 @default.
• W2009435973 crossrefType "journal-article" @default.
• W2009435973 hasAuthorship W2009435973A5006655487 @default.
• W2009435973 hasAuthorship W2009435973A5006988369 @default.
• W2009435973 hasAuthorship W2009435973A5023179804 @default.
• W2009435973 hasAuthorship W2009435973A5026391347 @default.
• W2009435973 hasAuthorship W2009435973A5057948544 @default.
• W2009435973 hasAuthorship W2009435973A5090283553 @default.
• W2009435973 hasConcept C126322002 @default.
• W2009435973 hasConcept C134018914 @default.
• W2009435973 hasConcept C146403970 @default.
• W2009435973 hasConcept C155710745 @default.
• W2009435973 hasConcept C178790620 @default.
• W2009435973 hasConcept C185263204 @default.
• W2009435973 hasConcept C185592680 @default.
• W2009435973 hasConcept C2776645727 @default.
• W2009435973 hasConcept C2776766087 @default.
• W2009435973 hasConcept C2779610285 @default.
• W2009435973 hasConcept C519581460 @default.
• W2009435973 hasConcept C533411734 @default.
• W2009435973 hasConcept C540031477 @default.
• W2009435973 hasConcept C55493867 @default.
• W2009435973 hasConcept C71924100 @default.
• W2009435973 hasConcept C7836513 @default.
• W2009435973 hasConcept C98274493 @default.
• W2009435973 hasConceptScore W2009435973C126322002 @default.
• W2009435973 hasConceptScore W2009435973C134018914 @default.

• next