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• W2009438187 abstract "The Escherichia coli version of the mammalian signal recognition particle (SRP) system is required for biogenesis of membrane proteins and contains two essential proteins: the SRP subunit Ffh and the SRP-receptor FtsY. Scattered in vivo studies have raised the possibility that expression of membrane proteins is inhibited in cells depleted of FtsY, whereas Ffh-depletion only affects their assembly. These differential results are surprising in light of the proposed model that FtsY and Ffh play a role in the same pathway of ribosome targeting to the membrane. Therefore, we decided to evaluate these unexpected results systematically.We characterized the following aspects of membrane protein biogenesis under conditions of either FtsY- or Ffh-depletion: (i) Protein expression, stability and localization; (ii) mRNA levels; (iii) folding and activity. With FtsY, we show that it is specifically required for expression of membrane proteins. Since no changes in mRNA levels or membrane protein stability were detected in cells depleted of FtsY, we propose that its depletion may lead to specific inhibition of translation of membrane proteins. Surprisingly, although FtsY and Ffh function in the same pathway, depletion of Ffh did not affect membrane protein expression or localization.Our results suggest that indeed, while FtsY-depletion affects earlier steps in the pathway (possibly translation), Ffh-depletion disrupts membrane protein biogenesis later during the targeting pathway by preventing their functional assembly in the membrane." @default.
• W2009438187 created "2016-06-24" @default.
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• W2009438187 date "2010-02-09" @default.
• W2009438187 modified "2023-10-16" @default.
• W2009438187 title "Membrane Protein Biogenesis in Ffh- or FtsY-Depleted Escherichia coli" @default.
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• W2009438187 doi "https://doi.org/10.1371/journal.pone.0009130" @default.
• W2009438187 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2817740" @default.
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