FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009441540> ?p ?o ?g. }

• W2009441540 endingPage "C1489" @default.
• W2009441540 startingPage "C1479" @default.
• W2009441540 abstract "Female reproductive tissues such as mammary glands, ovaries, uterus, and placenta are phenotypically dynamic, requiring tight integration of bioenergetic and apoptotic mechanisms. Mitochondrial zinc (Zn) pools have emerged as a central player in regulating bioenergetics and apoptosis. Zn must first be imported into mitochondria to modulate mitochondrion-specific functions; however, mitochondrial Zn import mechanisms have not been identified. Here we documented that the Zn transporter ZnT2 is associated with the inner mitochondrial membrane and acts as an auxiliary Zn importer into mitochondria in mammary cells. We found that attenuation of ZnT2 expression significantly reduced mitochondrial Zn uptake and total mitochondrial Zn pools. Moreover, expression of a ZnT2-hemagglutinin (HA) fusion protein was localized to mitochondria and significantly increased Zn uptake and mitochondrial Zn pools, directly implicating ZnT2 in Zn import into mitochondria. Confocal microscopy of truncated and point mutants of ZnT2-green fluorescent protein (GFP) fusion proteins revealed a histidine-rich motif ( 51 HH XH 54 ) in the NH 2 terminus that is important for mitochondrial targeting of ZnT2. More importantly, the expansion of mitochondrial Zn pools by ZnT2 overexpression significantly reduced ATP biogenesis and mitochondrial oxidation concurrent with increased apoptosis, suggesting a functional role for ZnT2-mediated Zn import into mitochondria. These results identify the first Zn transporter directly associated with mitochondria and suggest that unique secretory tissues such as the mammary gland require novel mechanisms to modulate mitochondrion-specific functions." @default.
• W2009441540 created "2016-06-24" @default.
• W2009441540 creator A5038541716 @default.
• W2009441540 creator A5053198596 @default.
• W2009441540 creator A5060725632 @default.
• W2009441540 date "2011-06-01" @default.
• W2009441540 modified "2023-10-18" @default.
• W2009441540 title "A histidine-rich motif mediates mitochondrial localization of ZnT2 to modulate mitochondrial function" @default.
• W2009441540 cites W1904560391 @default.
• W2009441540 cites W1967714958 @default.
• W2009441540 cites W1970611977 @default.
• W2009441540 cites W1971583817 @default.
• W2009441540 cites W1975428625 @default.
• W2009441540 cites W1978517380 @default.
• W2009441540 cites W1989737471 @default.
• W2009441540 cites W1992678832 @default.
• W2009441540 cites W1999985306 @default.
• W2009441540 cites W2000638098 @default.
• W2009441540 cites W2001009030 @default.
• W2009441540 cites W2001588476 @default.
• W2009441540 cites W2006544095 @default.
• W2009441540 cites W2015640374 @default.
• W2009441540 cites W2052815854 @default.
• W2009441540 cites W2057520074 @default.
• W2009441540 cites W2059643898 @default.
• W2009441540 cites W2060465768 @default.
• W2009441540 cites W2060910473 @default.
• W2009441540 cites W2061983173 @default.
• W2009441540 cites W2069988713 @default.
• W2009441540 cites W2078789414 @default.
• W2009441540 cites W2085025210 @default.
• W2009441540 cites W2085440025 @default.
• W2009441540 cites W2090938953 @default.
• W2009441540 cites W2095485607 @default.
• W2009441540 cites W2099434679 @default.
• W2009441540 cites W2104753463 @default.
• W2009441540 cites W2117393206 @default.
• W2009441540 cites W2123579381 @default.
• W2009441540 cites W2127394252 @default.
• W2009441540 cites W2131247679 @default.
• W2009441540 cites W2131437696 @default.
• W2009441540 cites W2147262386 @default.
• W2009441540 cites W2396592296 @default.
• W2009441540 doi "https://doi.org/10.1152/ajpcell.00420.2010" @default.
• W2009441540 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3118624" @default.
• W2009441540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21289295" @default.
• W2009441540 hasPublicationYear "2011" @default.
• W2009441540 type Work @default.
• W2009441540 sameAs 2009441540 @default.
• W2009441540 citedByCount "52" @default.
• W2009441540 countsByYear W20094415402012 @default.
• W2009441540 countsByYear W20094415402013 @default.
• W2009441540 countsByYear W20094415402014 @default.
• W2009441540 countsByYear W20094415402015 @default.
• W2009441540 countsByYear W20094415402016 @default.
• W2009441540 countsByYear W20094415402017 @default.
• W2009441540 countsByYear W20094415402018 @default.
• W2009441540 countsByYear W20094415402019 @default.
• W2009441540 countsByYear W20094415402020 @default.
• W2009441540 countsByYear W20094415402021 @default.
• W2009441540 countsByYear W20094415402022 @default.
• W2009441540 crossrefType "journal-article" @default.
• W2009441540 hasAuthorship W2009441540A5038541716 @default.
• W2009441540 hasAuthorship W2009441540A5053198596 @default.
• W2009441540 hasAuthorship W2009441540A5060725632 @default.
• W2009441540 hasBestOaLocation W20094415402 @default.
• W2009441540 hasConcept C100206155 @default.
• W2009441540 hasConcept C104317684 @default.
• W2009441540 hasConcept C163950672 @default.
• W2009441540 hasConcept C24586158 @default.
• W2009441540 hasConcept C28859421 @default.
• W2009441540 hasConcept C55493867 @default.
• W2009441540 hasConcept C57600042 @default.
• W2009441540 hasConcept C86803240 @default.
• W2009441540 hasConcept C95444343 @default.
• W2009441540 hasConceptScore W2009441540C100206155 @default.
• W2009441540 hasConceptScore W2009441540C104317684 @default.
• W2009441540 hasConceptScore W2009441540C163950672 @default.
• W2009441540 hasConceptScore W2009441540C24586158 @default.
• W2009441540 hasConceptScore W2009441540C28859421 @default.
• W2009441540 hasConceptScore W2009441540C55493867 @default.
• W2009441540 hasConceptScore W2009441540C57600042 @default.
• W2009441540 hasConceptScore W2009441540C86803240 @default.
• W2009441540 hasConceptScore W2009441540C95444343 @default.
• W2009441540 hasIssue "6" @default.
• W2009441540 hasLocation W20094415401 @default.
• W2009441540 hasLocation W20094415402 @default.
• W2009441540 hasLocation W20094415403 @default.
• W2009441540 hasLocation W20094415404 @default.
• W2009441540 hasOpenAccess W2009441540 @default.
• W2009441540 hasPrimaryLocation W20094415401 @default.
• W2009441540 hasRelatedWork W2013867688 @default.
• W2009441540 hasRelatedWork W2060102400 @default.
• W2009441540 hasRelatedWork W2115021528 @default.
• W2009441540 hasRelatedWork W2133486230 @default.
• W2009441540 hasRelatedWork W2133815054 @default.
• W2009441540 hasRelatedWork W2171278822 @default.
• W2009441540 hasRelatedWork W2331294491 @default.

• next