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- W2009444332 abstract "1. Helically-cut strips of rabbit aorta were used to examine the inhibitory effects of some antidepressants on the contractile responses produced by norepinephrine (NE), serotonin (5-HT) or K+. 2. The order of potency of antidepressants in antagonizing 5-HT-induced responses was: mianserin > amitriptyline > imipramine (IMI) > desipramine ⩾ nomifensine. With NE as agonist, the order of potency was: amitriptyline > mianserin > IMI > desipramine ⩾ nomifensine. Viloxazine (10−5 M) was ineffective on 5-HT- or NE-induced contractions. 3. For K+-induced contraction (which is mediated by Ca2+ entry into smooth muscle cells) tricyclic antidepressants were about equipotent with mianserin; nomifensine and viloxazine were relatively ineffective. 4. These results indicate that certain antidepressants have multiple effects on arterial smooth muscle. Such effects could underlie not only the side-effects, but also the therapeutic actions of these agents." @default.
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- W2009444332 title "Effects of antidepressants on receptor-activated and Ca2+-activated contractions of rabbit isolated aorta" @default.
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- W2009444332 doi "https://doi.org/10.1016/0306-3623(86)90103-5" @default.
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