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- W2009448641 abstract "A rapid and simple high performance liquid chromatography (HPLC) method with a UV detection (241 nm) was developed and validated for estimation of eplerenone from spiked human plasma. The analyte and the internal standard (valdecoxib) were extracted with a mixture of dichloromethane and diethyl ether. The chromatographic separation was performed on a HiQSil C-18HS column (250 mm×4.6 mm, 5 μm) with a mobile phase consisting of acetonitrile:water (50:50, v/v) at flow rate of 1 mL/min. The calibration curve was linear in the range 100–3200 ng/mL and the heteroscedasticity was minimized by using weighted least squares regression with weighting factor 1/X." @default.
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- W2009448641 date "2012-10-01" @default.
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- W2009448641 title "Development and validation of RP-HPLC method for estimation of eplerenone in spiked human plasma" @default.
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- W2009448641 doi "https://doi.org/10.1016/j.jpha.2012.04.006" @default.
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