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- W2009448974 abstract "The knob protein of Plasmodium falciparum is essential for the formation of knob-like protrusions on the host erythrocyte membrane. A functional domain of the knob protein was identified. This peptide formed stable complexes with the two major red cell skeletal proteins, spectrin and actin. When introduced into resealed normal erythrocytes, the peptide associated selectively with the cytoplasmic surface of the membrane and formed knob-like electron dense deposits. Knobs are thought to play an important role in the immunopathology of P. falciparum infections. Our findings provide a first step towards understanding the molecular basis for selective membrane changes at knobs." @default.
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- W2009448974 date "1991-02-01" @default.
- W2009448974 modified "2023-10-15" @default.
- W2009448974 title "Selective association of a fragment of the knob protein with spectrin, actin and the red cell membrane" @default.
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- W2009448974 doi "https://doi.org/10.1016/0166-6851(91)90003-o" @default.
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